Ethyl trifluoromethanesulfonate

Product Name: Ethyl trifluoromethanesulfonate
CAS No.: 425-75-2
Chemical Name: Ethyl trifluoromethanesulfonate
Synonyms: ETHYL TRIFLATE;Ethyl trifluoromethanesulf;Ethyltrifluormethansulfonat;Ethyl trifluoromethanesulfote;Ethyl trifluoromethesulfonate;ETHYL TRIFLUROMETHANSULFONATE;Ethyl trifluoromethylsulfonate;Ethyl trifluoroMethanesulfonat;ETHYL TRIFLUOROMETHANESULFONATE;ETHYL TRIFLURO METHANESULFONATE
CBNumber: CB4332659
Molecular Formula: C3H5F3O3S
Formula Weight: 178.13
MOL File: 425-75-2.mol

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Ethyl trifluoromethanesulfonate Property

Boiling point:: 115 °C (lit.)
Density: 1.374 g/mL at 25 °C (lit.)
refractive index: n20/D 1.336(lit.)
Flash point:: 96 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform, Methanol (Slightly)
form: Oil
color: Colourless
Specific Gravity: 1.374
Water Solubility: Hydrolyzes in water.
Sensitive: Hygroscopic
BRN: 1770746
Stability:: Volatile
InChIKey: UVECLJDRPFNRRQ-UHFFFAOYSA-N
CAS DataBase Reference: 425-75-2(CAS DataBase Reference)
EPA Substance Registry System: Methanesulfonic acid, trifluoro-, ethyl ester (425-75-2)

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Safety

Hazard Codes: C,T,F
Risk Statements: 10-34
Safety Statements: 16-26-36/37/39-45
RIDADR: UN 2920 8/PG 2
WGK Germany: 2
F: 3
Hazard Note: Highly Toxic
TSCA: Yes
HazardClass: 8
PackingGroup: II
HS Code: 29049090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 246530
Product name: Ethyl trifluoromethanesulfonate
Purity: 99%
Packaging: 1g
Price: $22.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: 246530
Product name: Ethyl trifluoromethanesulfonate
Purity: 99%
Packaging: 5g
Price: $57.5
Updated: 2024/03/01

TCI Chemical

Product number: T1191
Product name: Ethyl Trifluoromethanesulfonate
Purity: >98.0%(GC)
Packaging: 5g
Price: $58
Updated: 2024/03/01

TCI Chemical

Product number: T1191
Product name: Ethyl Trifluoromethanesulfonate
Purity: >98.0%(GC)
Packaging: 25g
Price: $198
Updated: 2024/03/01

Alfa Aesar

Product number: L03383
Product name: Ethyl trifluoromethanesulfonate, 99%
Packaging: 5g
Price: $48.7
Updated: 2021/12/16

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Ethyl trifluoromethanesulfonate Chemical Properties,Usage,Production

Description

Ethyl trifluoromethanesulfonate is a cationic polymerization agent used to produce polyurethane, polyacrylate, and other synthetic resins. It is an effective drug for the treatment of HIV infection and chronic bronchitis. Ethyl trifluoromethanesulfonate has been shown to inhibit the replication of HIV-1 virus at concentrations as low as 1 μM when tested in vitro. The mechanism of this drug's anti-HIV activity is unknown and may involve the inhibition of reverse transcriptase or proteases. Ethyl trifluoromethanesulfonate can be detected in vivo up to 4 hours after administration. This drug is metabolized into trifluoroacetic acid by esterases, glycosidases, and/or oxidases.

Chemical Properties

Clear colorless to yellow liquid

Uses

Ethyl trifluoromethanesulfonate is a powerful ethylating agent. due to the strong electron-absorbing ability of trifluoromethanesulfonyl, the reactivity is much higher than that of conventional alkylation reagents such as bichloride or alkyl sulfonate.

Synthesis

Triethyl orthoformate (4.44g,30mmol) was slowly added to trifluoromethanesulfonic anhydride (8.47g,30mmol) under ice bath, transferred to 25°C for reaction, monitored by NMR for 15 min, and the reaction was completed, distilled under reduced pressure to obtain 10.15g of ethyl trifluoromethanesulfonate colorless liquid in 94% yield.

Purification Methods

The ester reacts slowly with H2O and aqueous alkali. If its IR has no OH bands (~3000 cm-1) then purify it by redistillation. If OH bands are present, then dilute with dry Et2O and shake (carefully) with aqueous NaHCO3 until effervescence ceases, then wash with H2O and dry (MgSO4), filter, evaporate and distil the residue under a slight vacuum then at atmospheric pressure in a N2 atmosphere. IT IS A POWERFUL ALKYLATING AGENT, AND THE FUMES ARE VERY TOXIC — PERFORM ALL OPERATIONS IN AN EFFICIENT FUME CUPBOARD. [Gramstad & Haszeldine J Chem Soc 173 1956, Howells & McCown Chem Rev 77 69 1977, Beilstein 3 IV 34.]

Ethyl trifluoromethanesulfonate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl trifluoromethanesulfonate Suppliers

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View Lastest Price from Ethyl trifluoromethanesulfonate manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Ethyl trifluoromethanesulfonate 425-75-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-28

Hebei Yanxi Chemical Co., Ltd.

Product: Ethyl trifluoromethanesulfonate 425-75-2
Price: US $20.00-1.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 50 tons
Release date: 2023-09-12

Hebei Fengjia New Material Co., Ltd

Product: Ethyl trifluoromethanesulfonate 425-75-2
Price: US $30.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 100 tons
Release date: 2024-08-08

425-75-2, Ethyl trifluoromethanesulfonate Related Search:

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425-75-2

CF3SO3CH2CH3

CF3SO2OC2H5

C3H5F3SO3

Alkyl Transfer

Acylation

Synthetic Reagents

C-X Bond Formation (Non-Halogen)

Analytical/Chromatography

Derivatization Reagents

Derivatization Reagents GC

Reagents for Acylation

Acylation ReagentsDerivatization Reagents

Alkyl Transfer

C-X Bond Formation (Non-Halogen)

Synthetic Reagents