DBCO-(CH2)2-NH2-CO-(CH2)3COOH-NHS

Product Name: DBCO-(CH2)2-NH2-CO-(CH2)3COOH-NHS
CAS No.: 1393350-27-0
Chemical Name: DBCO-(CH2)2-NH2-CO-(CH2)3COOH-NHS
Synonyms: DBCO-NHS ester 3;DBCO-C5-NHS-ester;DBCO-NHS ester 3 (DIBAC-NHS);DBCO-(CH2)2-NH2-CO-(CH2)3COOH-NHS;2,5-Dioxo-1-pyrrolidinyl 11,12-didehydro-δ-oxodibenz[b,f]azocine-5(6H)-pentanoate;Dibenz[b,?f]azocine-5(6H)-pentanoic acid, 11,?12-didehydro-δ-oxo-, 2,5-dioxo-1-pyrrolidinyl ester;(2,5-Dioxopyrrolidin-1-yl) 5-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-5-oxopentanoate
CBNumber: CB43358339
Molecular Formula: C24H20N2O5
Formula Weight: 416.43
MOL File: 1393350-27-0.mol

More

Less

DBCO-(CH2)2-NH2-CO-(CH2)3COOH-NHS Property

Boiling point:: 679.2±65.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
form: Solid
pka: -0.19±0.20(Predicted)
color: White to off-white
InChI: InChI=1S/C24H20N2O5/c27-21(10-5-11-24(30)31-26-22(28)14-15-23(26)29)25-16-19-8-2-1-6-17(19)12-13-18-7-3-4-9-20(18)25/h1-4,6-9H,5,10-11,14-16H2
InChIKey: CFQHVJJWCDJMLI-UHFFFAOYSA-N
SMILES: C(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCCC(=O)ON1C(CCC1=O)=O

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

DBCO-(CH2)2-NH2-CO-(CH2)3COOH-NHS Chemical Properties,Usage,Production

Uses

DBCO-NHS ester 3 (Compound 12) is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester 3 is a derivative of Dibenzylcyclooctyne (DBCO) obtained by activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC)[1][2]. DBCO-NHS ester 3 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

Cleavable Linker

References

[1] Silvie A. Meeuwissen, et al. Copper-free click chemistry on polymersomes: pre- vs. post-self-assembly functionalization. Polymer Chemistry. 2012, 3: 1783-1795.
[2] Tang F, et al. Chemoenzymatic synthesis of glycoengineered IgG antibodies and glycosite-specific antibody-drug conjugates. Nat Protoc. 2017 Aug;12(8):1702-1721. DOI:10.1038/nprot.2017.058

DBCO-(CH2)2-NH2-CO-(CH2)3COOH-NHS Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

DBCO-(CH2)2-NH2-CO-(CH2)3COOH-NHS Suppliers

China 23 United States 3 Global 26

Shanghai Send Pharmaceutical Technology Co., Ltd.

Tel: 021-58088081 Q2635253576
Fax: QQ3382968513
Email: hailey@shsendpharm.com
Country: China
ProdList: 1984
Advantage: 55

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
Advantage: 58

Henan Lien Chemical Products Co., Ltd.

Tel: 0371-63357898 15378766539
Email: 535046669@qq.com
Country: China
ProdList: 4641
Advantage: 58

Guangzhou Younan Technology Co., Ltd

Tel: 020-82000279 18988941452
Fax: QQ：3283937693
Email: YN_research@163.com
Country: China
ProdList: 3011
Advantage: 58

Nanchang Tianzhen Biotechnology Co., Ltd

Tel: 13758194781 13173652190
Email: 522013271@qq.com
Country: China
ProdList: 2395
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Henan Kehong Biological Technology Co. LTD

Tel: 0371-86658258 ；0371-55969461
Fax: QQ：3311217266
Email: info@kehobio.com
Country: China
ProdList: 2575
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Shanghai Annengjian Biomedical Technology Co., LTD

Tel: 021-68781987 13818305065
Email: sales@energybiopharma.com
Country: China
ProdList: 652
Advantage: 58

Affinity（Wuhan）Ltd.

Tel: 15841022315
Email: sales@affinitytech.cn
Country: China
ProdList: 3000
Advantage: 58

Hangzhou Medicine Link Biotechnology Co., LTD

Tel: 15088318933 19357585311
Email: wxq6505168@163.com
Country: China
ProdList: 43
Advantage: 58

Shanghai Easy CDMO Co.,Ltd

Tel: 021-61734564 13854185395;
Email: info@easycdmo.com
Country: China
ProdList: 10024
Advantage: 58

Lianhe Aigen Pharmatech Co.,Ltd.

Tel: 18918657159
Email: sales-Aigen@lianhetech.com
Country: China
ProdList: 3000
Advantage: 58

Suzhou Meidi Senuo Pharmaceutical Technology Co., Ltd.

Tel: 13771642864
Fax: 1078336263
Email: snhuyu_2008@126.com
Country: China
ProdList: 1165
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Jilin Chinese Academy of Sciences-yanshen Technology

Tel: 18143011203
Email: ET-market@chemextension.com
Country: China
ProdList: 32048
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29257
Advantage: 58

Henan Mengtai Pharmaceutical Technology Co., Ltd

Tel: 176345344 7 17634854698
Email: 1959525201@qq.com
Country: China
ProdList: 10000
Advantage: 58

YantaiBio

Tel: 13758194781 15083780366
Email: wudegui@tanzhenbio.com
Country: China
ProdList: 1591
Advantage: 58

Suzhou Derivative Biotechnology Co., Ltd.

Tel: 13915541704
Email: 2436368162@qq.com
Country: China
ProdList: 554
Advantage: 58

HUBEI DING KOSIN TECHNOLOGY

Tel: +8613524650931
Email: jason@kosinbio.com
Country: China
ProdList: 953
Advantage: 58

1393350-27-0, DBCO-(CH2)2-NH2-CO-(CH2)3COOH-NHSRelated Search:

DBCO-PEG1-amine 5,8,11,14,17,20-Hexaoxa-2,23-diazaheptacosanoic acid, 27-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-24,27-dioxo-, 1,1-dimethylethyl ester DBCO-PEG3-CH2CO-NHS DBCO-PEG4-amine DBCO-PEG4-SE DBCO-NHS Ester DBCO-PEG2-NH-Boc Azadibenzocyclooctyne-PEG1-N-hydroxysuccinimidyl ester DBCO-PEG4-DBCO DBCO-PEG3-acid Azadibenzocyclooctyne-Biotin conjugate 4,7,10,13-Tetraoxa-16-azaheneicosanoic acid, 21-(11,12-dihydrodibenz[b,f]azocin-5(6H)-yl)-17,21-dioxo-, 2,3,5,6-tetrafluorophenyl ester DBCO-NH-(CH2)4COOH DBCO-PEG3-amine DBCO-NH-Boc

DBCO-(CH2)2-NH2-CO-(CH2)3COOH-NHS

DBCO-NHS ester 3 (DIBAC-NHS)

DBCO-NHS ester 3

Dibenz[b,?f]azocine-5(6H)-pentanoic acid, 11,?12-didehydro-δ-oxo-, 2,5-dioxo-1-pyrrolidinyl ester

(2,5-Dioxopyrrolidin-1-yl) 5-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-5-oxopentanoate

DBCO-C5-NHS-ester

2,5-Dioxo-1-pyrrolidinyl 11,12-didehydro-δ-oxodibenz[b,f]azocine-5(6H)-pentanoate

1393350-27-0

ADC LINKER