Propargyl-PEG1-SS-PEG1-PFP ester

Product Name: Propargyl-PEG1-SS-PEG1-PFP ester
CAS No.: 1817735-30-0
Chemical Name: Propargyl-PEG1-SS-PEG1-PFP ester
Synonyms: Propargyl-PEG1-SS-PEG1-PFP ester;Perfluorophenyl 3-[2-[[2-(Prop-2-yn-1-yloxy)ethyl]disulfanyl]ethoxy]propanoate;perfluorophenyl 3-(2-((2-(prop-2-yn-1-yloxy)ethyl)disulfaneyl)ethoxy)propanoate;Propanoic acid, 3-[2-[[2-(2-propyn-1-yloxy)ethyl]dithio]ethoxy]-, 2,3,4,5,6-pentafluorophenyl ester
CBNumber: CB43363988
Molecular Formula: C16H15F5O4S2
Formula Weight: 430.41
MOL File: 1817735-30-0.mol

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Propargyl-PEG1-SS-PEG1-PFP ester Property

Boiling point:: 477.0±45.0 °C(Predicted)
Density: 1.413±0.06 g/cm3(Predicted)

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Hazard and Precautionary Statements (GHS)

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Propargyl-PEG1-SS-PEG1-PFP ester Chemical Properties,Usage,Production

Description

Propargyl-PEG1-SS-PEG1-PFP ester is a Click Chemistry crosslinker. PFP ester is reactive with amine-bearing molecule. The propargyl groups can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages.

Uses

Propargyl-PEG1-SS-PEG1-PFP ester is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG1-SS-PEG1-PFP ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

Disulfide Cleavable Linker; Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

Propargyl-PEG1-SS-PEG1-PFP ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Propargyl-PEG1-SS-PEG1-PFP ester Suppliers

China 19 United States 3 Global 22

TargetMol Chemicals Inc.

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Email: marketing@targetmol.com
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Aladdin Scientific

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MedChemExpress

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View Lastest Price from Propargyl-PEG1-SS-PEG1-PFP ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Propargyl-PEG1-SS-PEG1-PFP ester 1817735-30-0
Price: US $0.00/mg
Min. Order: 50mg
Purity: >95.00%
Supply Ability: 50mg
Release date: 2024-03-21

1817735-30-0, Propargyl-PEG1-SS-PEG1-PFP esterRelated Search:

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Propargyl-PEG1-SS-PEG1-PFP ester

Propanoic acid, 3-[2-[[2-(2-propyn-1-yloxy)ethyl]dithio]ethoxy]-, 2,3,4,5,6-pentafluorophenyl ester

perfluorophenyl 3-(2-((2-(prop-2-yn-1-yloxy)ethyl)disulfaneyl)ethoxy)propanoate

Perfluorophenyl 3-[2-[[2-(Prop-2-yn-1-yloxy)ethyl]disulfanyl]ethoxy]propanoate

1817735-30-0

C16H15F5O4S2