ChemicalBook > CAS DataBase List > 4,5-Difluoro-2-nitrobenzoic acid

4,5-Difluoro-2-nitrobenzoic acid

Product Name: 4,5-Difluoro-2-nitrobenzoic acid
CAS No.: 20372-63-8
Chemical Name: 4,5-Difluoro-2-nitrobenzoic acid
Synonyms: 4,5-Difluoro-2-nitrobenzoicaci;4,5-DIFLUORO-2-NITROBENZOIC ACID;2-NITRO-4,5-DIFLUOROBENZOIC ACID;4,5-Difluoro-2-nitrobenzoicAcid>4,5-two fluoro -2-Nitrobenzoic Acid;Benzoic acid, 4,5-difluoro-2-nitro-;4,5-Difluoro-2-nitrobenzoic acid, 97%,;4,5-difluoro-2-nitrobenzenecarboxylic acid;4,5-Difluoro-2-nitrobenzoic acid ISO 9001：2015 REACH
CBNumber: CB4387361
Molecular Formula: C7H3F2NO4
Formula Weight: 203.1
MOL File: 20372-63-8.mol

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4,5-Difluoro-2-nitrobenzoic acid Property

Melting point:: 165-167 °C (lit.)
Boiling point:: 349.7±42.0 °C(Predicted)
Density: 1.661±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 1.85±0.25(Predicted)
color: White to Light yellow
CAS DataBase Reference: 20372-63-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 468983
Product name: 4,5-Difluoro-2-nitrobenzoic acid
Purity: 99%
Packaging: 5g
Price: $65.7
Updated: 2023/06/20

Sigma-Aldrich

Product number: 468983
Product name: 4,5-Difluoro-2-nitrobenzoic acid
Purity: 99%
Packaging: 1g
Price: $47.8
Updated: 2022/05/15

TCI Chemical

Product number: D3555
Product name: 4,5-Difluoro-2-nitrobenzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $56
Updated: 2025/07/31

TCI Chemical

Product number: D3555
Product name: 4,5-Difluoro-2-nitrobenzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $190
Updated: 2025/07/31

TRC

Product number: D452213
Product name: 4,5-Difluoro-2-nitrobenzoic acid
Packaging: 250mg
Price: $45
Updated: 2021/12/16

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4,5-Difluoro-2-nitrobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

Solid

General Description

4,5-Difluoro-2-nitrobenzoic acid can be obtained from the nitration of 4,5-difluorobenzoic acid or 3,4-difluorobenzoic acid.

Synthesis

455-86-7

20372-63-8

Step 1: 3,4-difluorobenzoic acid (120.0 g, 0.7589 mol) and concentrated sulfuric acid (96.4%, 1.0 L) were added to a 2 L three-necked round-bottom flask. The mixture was mechanically stirred at room temperature for 1.0 hour and then cooled to 0°C. Fuming nitric acid (>90% HNO3 content, 57.30 mL, 1.273 mmol, 1.677 eq.) was added dropwise over 30 minutes. After addition, the reaction mixture was stirred at room temperature for 16 hours. Subsequently, the reaction mixture was slowly poured into crushed ice (5 Kg) under stirring. 4,5-difluoro-2-nitrobenzoic acid precipitated as a yellow solid. The slurry was continued to be stirred at 0 °C for 0.5 h. The solid product was then collected by filtration through a Brinell funnel. The yellowish solid was washed with cold water and air dried; 120 g of product was obtained in 79% yield.

References

[1] Journal of Heterocyclic Chemistry, 2001, vol. 38, # 1, p. 61 - 67
[2] Farmaco, 2001, vol. 56, # 9, p. 664 - 676
[3] Patent: WO2008/36843, 2008, A2. Location in patent: Page/Page column 31-33
[4] Patent: US4994606, 1991, A
[5] Patent: US5003103, 1991, A

4,5-Difluoro-2-nitrobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4,5-Difluoro-2-nitrobenzoic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4,5-Difluoro-2-nitrobenzoic acid 20372-63-8
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-28

Henan Fengda Chemical Co., Ltd

Product: 4,5-Difluoro-2-nitrobenzoic acid 20372-63-8
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-25

Shaanxi Dideu Medichem Co. Ltd

Product: 4,5-Difluoro-2-nitrobenzoic acid 20372-63-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 100 tons
Release date: 2020-01-07

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2-NITRO-4,5-DIFLUOROBENZOIC ACID

4,5-DIFLUORO-2-NITROBENZOIC ACID

4,5-difluoro-2-nitrobenzenecarboxylic acid

4,5-two fluoro -2-Nitrobenzoic Acid

4,5-Difluoro-2-nitrobenzoicAcid&gt

Benzoic acid, 4,5-difluoro-2-nitro-

4,5-Difluoro-2-nitrobenzoicaci

4,5-Difluoro-2-nitrobenzoic acid ISO 9001：2015 REACH

4,5-Difluoro-2-nitrobenzoic acid, 97%,

20372-63-8

C7H3F2NO4

C7H3NO4F2

F2C6H2NO2CO2H

Organic Building Blocks

Carboxylic Acids

Carbonyl Compounds

Building Blocks

Carbonyl Compounds

Carboxylic Acids

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

Benzoic acid

API intermediates

Acids and Derivatives