4,5-Difluoro-2-nitrobenzoic acid
- Product Name
- 4,5-Difluoro-2-nitrobenzoic acid
- CAS No.
- 20372-63-8
- Chemical Name
- 4,5-Difluoro-2-nitrobenzoic acid
- Synonyms
- 4,5-Difluoro-2-nitrobenzoicaci;4,5-DIFLUORO-2-NITROBENZOIC ACID;2-NITRO-4,5-DIFLUOROBENZOIC ACID;4,5-Difluoro-2-nitrobenzoicAcid>4,5-two fluoro -2-Nitrobenzoic Acid;Benzoic acid, 4,5-difluoro-2-nitro-;4,5-Difluoro-2-nitrobenzoic acid, 97%,;4,5-difluoro-2-nitrobenzenecarboxylic acid;4,5-Difluoro-2-nitrobenzoic acid ISO 9001：2015 REACH
- CBNumber
- CB4387361
- Molecular Formula
- C7H3F2NO4
- Formula Weight
- 203.1
- MOL File
- 20372-63-8.mol
4,5-Difluoro-2-nitrobenzoic acid Property
- Melting point:
- 165-167 °C (lit.)
- Boiling point:
- 349.7±42.0 °C(Predicted)
- Density
- 1.661±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 1.85±0.25(Predicted)
- color
- White to Light yellow
- CAS DataBase Reference
- 20372-63-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 468983
- Product name
- 4,5-Difluoro-2-nitrobenzoic acid
- Purity
- 99%
- Packaging
- 5g
- Price
- $65.7
- Updated
- 2023/06/20
- Product number
- 468983
- Product name
- 4,5-Difluoro-2-nitrobenzoic acid
- Purity
- 99%
- Packaging
- 1g
- Price
- $47.8
- Updated
- 2022/05/15
- Product number
- D3555
- Product name
- 4,5-Difluoro-2-nitrobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $56
- Updated
- 2025/07/31
- Product number
- D3555
- Product name
- 4,5-Difluoro-2-nitrobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $190
- Updated
- 2025/07/31
- Product number
- D452213
- Product name
- 4,5-Difluoro-2-nitrobenzoic acid
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
4,5-Difluoro-2-nitrobenzoic acid Chemical Properties,Usage,Production
Chemical Properties
Solid
General Description
4,5-Difluoro-2-nitrobenzoic acid can be obtained from the nitration of 4,5-difluorobenzoic acid or 3,4-difluorobenzoic acid.
Synthesis
455-86-7
20372-63-8
Step 1: 3,4-difluorobenzoic acid (120.0 g, 0.7589 mol) and concentrated sulfuric acid (96.4%, 1.0 L) were added to a 2 L three-necked round-bottom flask. The mixture was mechanically stirred at room temperature for 1.0 hour and then cooled to 0°C. Fuming nitric acid (>90% HNO3 content, 57.30 mL, 1.273 mmol, 1.677 eq.) was added dropwise over 30 minutes. After addition, the reaction mixture was stirred at room temperature for 16 hours. Subsequently, the reaction mixture was slowly poured into crushed ice (5 Kg) under stirring. 4,5-difluoro-2-nitrobenzoic acid precipitated as a yellow solid. The slurry was continued to be stirred at 0 °C for 0.5 h. The solid product was then collected by filtration through a Brinell funnel. The yellowish solid was washed with cold water and air dried; 120 g of product was obtained in 79% yield.
References
[1] Journal of Heterocyclic Chemistry, 2001, vol. 38, # 1, p. 61 - 67
[2] Farmaco, 2001, vol. 56, # 9, p. 664 - 676
[3] Patent: WO2008/36843, 2008, A2. Location in patent: Page/Page column 31-33
[4] Patent: US4994606, 1991, A
[5] Patent: US5003103, 1991, A
4,5-Difluoro-2-nitrobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4,5-Difluoro-2-nitrobenzoic acid Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
View Lastest Price from 4,5-Difluoro-2-nitrobenzoic acid manufacturers
- Product
- 4,5-Difluoro-2-nitrobenzoic acid 20372-63-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-28
- Product
- 4,5-Difluoro-2-nitrobenzoic acid 20372-63-8
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-25
- Product
- 4,5-Difluoro-2-nitrobenzoic acid 20372-63-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 100 tons
- Release date
- 2020-01-07