BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE

Product Name: BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE
CAS No.: 200626-61-5
Chemical Name: BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE
Synonyms: CS-2249;ITSA-1(ITSA1);IFLAB-BB F0451-3184;1-(2,4-Dichlorobenzoyl)-1H-benzotriazole;BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE;Methanone, 1H-benzotriazol-1-yl(2,4-dichlorophenyl)-;inhibit,Histone deacetylases,ITSA-1,Inhibitor,HDAC,ITSA 1;(1H-Benzo[d][1,2,3]triazol-1-yl)(2,4-dichlorophenyl)methanone
CBNumber: CB4697730
Molecular Formula: C13H7Cl2N3O
Formula Weight: 292.12
MOL File: 200626-61-5.mol

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BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE Property

Melting point:: 119-121°C
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO: ~28mg/mL
form: solid
color: White to Off-White

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18681
Product name: ITSA1
Purity: ≥95%
Packaging: 10mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18681
Product name: ITSA1
Purity: ≥95%
Packaging: 25mg
Price: $92
Updated: 2024/03/01

Cayman Chemical

Product number: 18681
Product name: ITSA1
Purity: ≥95%
Packaging: 50mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 18681
Product name: ITSA1
Purity: ≥95%
Packaging: 100mg
Price: $257
Updated: 2024/03/01

ApexBio Technology

Product number: B7816
Product name: ITSA-1(ITSA1)
Packaging: 100mg
Price: $347
Updated: 2021/12/16

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BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE Chemical Properties,Usage,Production

Uses

Histone deacetylase (HDAC) inhibitors?are able to interrupt cell cycle progression in transformed cell lines and may be explored as new clinical agents in cancer therapy. 1-(2,4-Dichlorobenzoyl)-1H-benzotriazole has been shown to suppress the biological effects induced by the HDAC inhibitor, Trichostatin A (T774710).

Definition

ChEBI: 1-(2,4-dichlorobenzoyl)-1H-1,2,3-benzotriazole is a member of the class of benzamides that is obtained by the formal condensation of 2,4-dichlorobenzoic acid and benzotriazole. It acts as an inhibitor for tubulin acetylation mediated by trichostatin A. It has a role as an inhibitor. It is a member of benzotriazoles, a member of benzamides and a dichlorobenzene. It is functionally related to a 2,4-dichlorobenzoic acid and a benzotriazole.

Biological Activity

itsa-1 (itsa1) is an hdac activator through trichostatin a (tsa) suppression.trichostatin a (tsa), a streptomyces metabolite, can specifically inhibit mammalian histone deacetylase at a nanomolar concentration causing accumulation of highly acetylated histone molecules in mammalian cells.

in vitro

previous study reported that in murine embryonic stem cells, tsa treatment for 23 hours inhibited brdu incorporation compared with the control. tsa-pretreated cells incubated with itsa1, however, could incorporate brdu at concentrations where it was inhibited by tsa alone. moreover, itsa1 treatment was able to revert the tsa-arrested population to a normal cell cycle distribution. tsa treatment at 300 nm to a549 cells for 2 hours noticeably increased the levels of acetyl-histone h3, whereas subsequent incubation with itsa1 at 50 μm for 2 hours reduced histone acetylation to the baseline level. in addition, cells pretreated with itsa1 before addition of tsa showed increased acetylation levels, which was a characteristic of tsa treatment alone. these results suggested that the target of itsa1 was not present until induced by tsa. furthermore, the itsa1 treatment alone at 50 or 100 μm was not effective on hdac activity, demonstrating that itsa1 could directly affect hdac function [1].

References

[1] koeller km, haggarty sj, perkins bd, leykin i, wong jc, kao mc, schreiber sl. chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation. chem biol. 2003 may;10(5):397-410.

BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE Suppliers

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View Lastest Price from BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE manufacturers

Career Henan Chemical Co

Product: BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE 200626-61-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-20

200626-61-5, BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONERelated Search:

Sodium Butyrate Suberohydroxamic acid 1H-Benz[de]isoquinoline-2(3H)-butanamide SCRIPTAID SPLITOMICIN Sodium 4-phenylbutyrate APICIDIN CAY10603 OXAMFLATIN Tubacin Entinostat HC TOXIN M344 Parthenolide 1-METHYLBENZOTRIAZOLE BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE 1H-BENZOTRIAZOLE-1-CARBOXALDEHYDE 1-ACETYL-1H-BENZOTRIAZOLE

IFLAB-BB F0451-3184

BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE

1-(2,4-Dichlorobenzoyl)-1H-benzotriazole

ITSA-1(ITSA1)

CS-2249

Methanone, 1H-benzotriazol-1-yl(2,4-dichlorophenyl)-

(1H-Benzo[d][1,2,3]triazol-1-yl)(2,4-dichlorophenyl)methanone

inhibit,Histone deacetylases,ITSA-1,Inhibitor,HDAC,ITSA 1

200626-61-5

Cell Signaling and Neuroscience

Cell Biology

BioChemical

Gene Regulation and Expression

DNA-RNA Transcription Regulators