Thalidomide-O-amido-C8-NH2 hydrochloride
- Product Name
- Thalidomide-O-amido-C8-NH2 hydrochloride
- CAS No.
- 2415263-07-7
- Chemical Name
- Thalidomide-O-amido-C8-NH2 hydrochloride
- Synonyms
- Thalidomide-O-amido-C8-NH2 hydrochloride;N-(8-aminooctyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide hydrochloride
- CBNumber
- CB49023929
- Molecular Formula
- C23H31ClN4O6
- Formula Weight
- 494.97
- MOL File
- 2415263-07-7.mol
Thalidomide-O-amido-C8-NH2 hydrochloride Chemical Properties,Usage,Production
Biological Activity
Thalidomide-O-amido-C8-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1]. Thalidomide-O-amido-C8-NH2 is a degron-linker (refer to Compound DL7-TL). The PROTAC linker is bound lo at least one targeting ligand. Degron-linker-targeting ligand, wherein the linker is covalently bound lo at least one degron and at least one targeting ligand, the degron is a compound capable of binding to an ubiquitin ligase such as an E3 ubiquitin ligase (e g, cereblon), and the targeting ligand is capable of binding to the targeted protein(s)[1].
storage
Desiccate at RT
References
[1]. James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.
Thalidomide-O-amido-C8-NH2 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Thalidomide-O-amido-C8-NH2 hydrochloride manufacturers
- Product
- Thalidomide-O-amido-C8-NH2 hydrochloride 2415263-07-7
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- >98.00%
- Supply Ability
- 100mg
- Release date
- 2024-04-01