ChemicalBook > CAS DataBase List > Methyl 6-bromopicolinate
Methyl 6-bromopicolinate
- Product Name
- Methyl 6-bromopicolinate
- CAS No.
- 26218-75-7
- Chemical Name
- Methyl 6-bromopicolinate
- Synonyms
- RARECHEM AL BF 0899;METHYL 6-BROMOPICOLINATE;6-Bromopyridine-2-carboxyL;6-Bromopyridine-2-carboxylate;Methyl 6-broMo-2-pyridinecarboxylat;Methyl 6-Bromoyridine-2-carboxylate;Methy16-bromopyridine-2-carboxylate;METHYL 6-BROMOPYRIDINE-2-CARBOXYLATE;METHYL 6-BROMO-2-PYRIDINECARBOXYLATE;Methyle6-bromopyridine-2-carboxylate
- CBNumber
- CB5273575
- Molecular Formula
- C7H6BrNO2
- Formula Weight
- 216.03
- MOL File
- 26218-75-7.mol
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Methyl 6-bromopicolinate Property
- Melting point:
- 92-96 °C(lit.)
- Boiling point:
- 289.7±20.0 °C(Predicted)
- Density
- 1.579±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- soluble in Methanol
- pka
- -1.03±0.10(Predicted)
- form
- Crystalline Powder or Needles
- color
- White to pale pink to pale brown to yellow
- InChI
- InChI=1S/C7H6BrNO2/c1-11-7(10)5-3-2-4-6(8)9-5/h2-4H,1H3
- InChIKey
- SGNCOKUHMXLGAH-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NC(Br)=CC=C1
- CAS DataBase Reference
- 26218-75-7(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 650110
- Product name
- Methyl 6-Bromopyridine-2-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $29.7
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- 650110
- Product name
- Methyl 6-Bromopyridine-2-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $148
- Updated
- 2021/12/16
TCI Chemical
- Product number
- M2342
- Product name
- Methyl 6-Bromopyridine-2-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $18
- Updated
- 2025/07/31
TCI Chemical
- Product number
- M2342
- Product name
- Methyl 6-Bromopyridine-2-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $54
- Updated
- 2025/07/31
TRC
- Product number
- M296135
- Product name
- Methyl6-bromopicolinate
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
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Methyl 6-bromopicolinate Chemical Properties,Usage,Production
Chemical Properties
White to off-white solid
Uses
Methyl 6-bromopicolinate, also known as Methyl 6-bromopyridine-2-carboxylate, is a halogenated pyridine derivative that can be used in esterolysis reactions to form 6-Bromopicolinic acid.It can also be used in substitution reactions or cross-couplings to synthesise other pyridine compounds.
Synthesis
67-56-1
21190-87-4
26218-75-7
The general procedure for the synthesis of methyl 6-bromo-2-pyridinecarboxylate from methanol and 6-bromo-2-pyridinecarboxylic acid is as follows: 1. 6-bromo-2-pyridine carboxylic acid (6.000 g) was dissolved in methanol (180 mL) containing concentrated hydrochloric acid and heated to reflux. 2. Sulfuric acid (2 mL) was added and the reaction continued to reflux for 4 hours. 3. Upon completion of the reaction, the reaction mixture was cooled to about 0°C and concentrated. 4. Ammonia (4.8 mL) was added to the concentrated mixture. 5. The resulting solution was evaporated to give a white solid residue. 6. 6. The white solid was dissolved in a solvent mixture of dichloromethane (100 mL) and brine (100 mL), and the organic layer was separated with sufficient shaking. 7. The organic layer was dried with magnesium sulfate and the solvent was evaporated to give the white solid product methyl 6-bromo-2-pyridinecarboxylate (6.300 g, 98% yield). Product characterization data: 1H NMR (400 MHz, CDCl3) δ 4.00 (3H, s), 7.66-7.74 (2H, m), 8.07-8.13 (1H, m).
References
[1] Patent: WO2003/84917, 2003, A1. Location in patent: Page/Page column 26
[2] Journal of Agricultural and Food Chemistry, 2016, vol. 64, # 18, p. 3533 - 3537
[3] Patent: WO2017/9798, 2017, A1. Location in patent: Page/Page column 92
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 2, p. 722 - 748
[5] Inorganic Chemistry, 2018, vol. 57, # 13, p. 7512 - 7515
Methyl 6-bromopicolinate Preparation Products And Raw materials
Raw materials
p-Toluenesulfonic acid
6-Bromopicolinic acid
Ethyl acetate
Sodium bicarbonate
Methanol
Magnesium sulfate
Thionyl chloride
PETROLEUM ETHER
Magnesium
Sulfuric acid
Sodium carbonate
Preparation Products
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View Lastest Price from Methyl 6-bromopicolinate manufacturers
Shaanxi Dideu New Materials Co. Ltd
- Product
- Methyl 6-bromopicolinate 26218-75-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-29
Shanghai UCHEM Inc.
- Product
- Methyl 6-bromopyridine-2-carboxylate 26218-75-7
- Price
- US $34.00-210.00/g
- Min. Order
- 10g
- Purity
- 0.98
- Supply Ability
- 25kg
- Release date
- 2023-12-13
Henan Fengda Chemical Co., Ltd
- Product
- 6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 26218-75-7
- Price
- US $6.00-0.20/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-03
26218-75-7, Methyl 6-bromopicolinateRelated Search:
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