ChemicalBook > CAS DataBase List > LY3214996

LY3214996

Product Name
LY3214996
CAS No.
1951483-29-6
Chemical Name
LY3214996
Synonyms
CS-2495;LY3214996;Temuterkib;Temuterkib (LY3214996);LY-3214996 (LY3214996);LY-3214996,LY 3214996,inhibit,Extracellular signal regulated kinases,Temuterkib,Inhibitor,ERK;6,6-dimethyl-2-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one;4H-Thieno[2,3-c]pyrrol-4-one, 5,6-dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-
CBNumber
CB53168760
Molecular Formula
C22H27N7O2S
Formula Weight
453.56
MOL File
1951483-29-6.mol
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LY3214996 Property

Boiling point:
711.5±70.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:23.5(Max Conc. mg/mL);51.81(Max Conc. mM)
Ethanol:16.0(Max Conc. mg/mL);35.28(Max Conc. mM)
form 
A crystalline solid
pka
6.58±0.10(Predicted)
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27936
Product name
LY3214996
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
27936
Product name
LY3214996
Packaging
25mg
Price
$1026
Updated
2024/03/01
Cayman Chemical
Product number
27936
Product name
LY3214996
Packaging
5mg
Price
$233
Updated
2024/03/01
Cayman Chemical
Product number
27936
Product name
LY3214996
Packaging
10mg
Price
$437
Updated
2024/03/01
ChemScene
Product number
CS-6974
Product name
LY3214996
Purity
99.54%
Packaging
1mg
Price
$80
Updated
2021/12/16
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LY3214996 Chemical Properties,Usage,Production

Description

LY3214996 is an inhibitor of ERK1 and ERK2 (IC50 = 5 nM for both). It inhibits cell proliferation of tumor cells in vitro, including those expressing B-RAF, N-Ras, or K-Ras mutations. LY3214996 inhibits tumor growth in B-RAF or N-Ras mutant melanoma, B-RAF or K-Ras mutant colorectal, lung, and pancreatic cancer mouse xenograft models, as well as patient-derived xenograft (PDX) mouse models.

LY3214996 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY3214996 Suppliers

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1951483-29-6, LY3214996Related Search:

LY-2940094 LY2828360 LY-2562175 LY2228820 Etalocib LY2584702 LY 2784544 LY2409881 trihydrochloride LY-364947 LY 88074 (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide LY-3177833 2-(4-((4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)pyridin-2-yl)amino)pyridin-2-yl)propan-2-ol LY2409881 Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2 LY3023414 LY 294002 HYDROCHLORIDE LY2955303

  • LY3214996
  • 6,6-dimethyl-2-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one
  • CS-2495
  • 4H-Thieno[2,3-c]pyrrol-4-one, 5,6-dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-
  • Temuterkib
  • Temuterkib (LY3214996)
  • LY-3214996,LY 3214996,inhibit,Extracellular signal regulated kinases,Temuterkib,Inhibitor,ERK
  • LY-3214996 (LY3214996)
  • 1951483-29-6