4-Chloro-3-fluoroaniline

Uses

Product Name: 4-Chloro-3-fluoroaniline
CAS No.: 367-22-6
Chemical Name: 4-Chloro-3-fluoroaniline
Synonyms: BUTTPARK 44\01-97;Gefitinib Impurity 96;Fluoro-4-chloroaniline;4-Chloro-3-fluoroanline;3-FLUORO-4-CHLOROANILINE;4-CHLORO-3-FLUOROANILINE;4-Chloro-3-fluoroaniline98%;4-Chloro-3-fluoroaniline >4-Chloro-3-fluoroaniline 98%;4-chloro-3-fluorobenzenaMine
CBNumber: CB5343050
Molecular Formula: C6H5ClFN
Formula Weight: 145.56
MOL File: 367-22-6.mol

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4-Chloro-3-fluoroaniline Property

Melting point:: 61
Boiling point:: 226°C(lit.)
Density: 1.349±0.06 g/cm3(Predicted)
Flash point:: 60 - 62°C
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 2.94±0.10(Predicted)
color: White to Gray to Red
BRN: 2716278
InChI: InChI=1S/C6H5ClFN/c7-5-2-1-4(9)3-6(5)8/h1-3H,9H2
InChIKey: ACMJJQYSPUPMPN-UHFFFAOYSA-N
SMILES: C1(N)=CC=C(Cl)C(F)=C1
CAS DataBase Reference: 367-22-6(CAS DataBase Reference)

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Safety

Hazard Codes: T,Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36/37/39-63-45-38
RIDADR: UN2811
WGK Germany: 3
Hazard Note: Toxic
HazardClass: 6.1
PackingGroup: III
HS Code: 29214200

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 779970
Product name: 4-Chloro-3-fluoroaniline
Purity: ≥97.0% (GC)
Packaging: 5g
Price: $66.4
Updated: 2023/06/20

TCI Chemical

Product number: C2512
Product name: 4-Chloro-3-fluoroaniline
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $59
Updated: 2025/07/31

TCI Chemical

Product number: C2512
Product name: 4-Chloro-3-fluoroaniline
Purity: >97.0%(GC)(T)
Packaging: 25g
Price: $234
Updated: 2025/07/31

TRC

Product number: C367100
Product name: 4-Chloro-3-fluoroaniline
Packaging: 25g
Price: $300
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC34022
Product name: 4-Chloro-3-fluoroaniline
Packaging: 250g
Price: $300
Updated: 2021/12/16

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4-Chloro-3-fluoroaniline Chemical Properties,Usage,Production

Uses

4-Chloro-3-fluoroaniline is used in the synthesis of Methyl 5-Chloro-4-fluoro-1H-indole-2-carboxylate; a key intermediate towards phosphoindole inhibitors of HIV non-nucleoside reverse transcriptase. 4-Chloro-3-fluoroaniline is also used in the synthesis of 3-Deschloro-4-desfluoro-4-chloro-3-fluoro Gefitinib (D289540) which is an impurity of the tyrosine kinase inhibitor Gefitinib.

Chemical Properties

White to light yellow solid

Uses

4-Chloro-3-fluoroaniline is used in the synthesis of Methyl 5-Chloro-4-fluoro-1H-indole-2-carboxylate

Synthesis

372-19-0

367-22-6

1. A CHCl3 (20.0 mL) solution of N-chlorosuccinimide (NCS) was added slowly and dropwise to a stirred CHCl3 (30.0 mL) solution of 3-fluoroaniline (1.11 g, 10.0 mmol) at 0 °C. 2. The reaction mixture was stirred continuously at 0 °C for 42 hours. 3. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and the residue was dissolved in Et2O. 4. The mixture was washed with water and subsequently dried with MgSO4. 5. After concentration under reduced pressure, the mixture was purified by rapid chromatography on silica gel, using EtOAc/hexane as eluent, to afford 4-chloro-3-fluoroaniline (259.4 g, 18% yield) as a crystalline solid. 6. To a stirred solution of the above 4-chloro-3-fluoroaniline (259.4 mg, 1.78 mmol) in THF (8.9 mL) was added ethyl chloroacetate (237.3 μL, 2.14 mmol) and Et3N (296.6 μL, 2.14 mmol) sequentially at 0 °C. 7. The mixture was stirred at room temperature for 12 hours. 8. After filtration to remove the precipitate, the filtrate was concentrated under reduced pressure. 9. The residue was dissolved in EtOAc, washed sequentially with 1.0 M HCl, saturated NaHCO3 solution and brine, and then dried with MgSO4. 10. After concentration under pressure, 3-fluoro-4-chloroaniline 6a (435.2 mg, 99% yield) was obtained as brown crystals, which could be used without further purification.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 11, p. 3282 - 3285
[2] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 9, p. 2518 - 2526
[3] Patent: EP1342717, 2003, A1
[4] Patent: US2003/236267, 2003, A1. Location in patent: Page 30

4-Chloro-3-fluoroaniline Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from 4-Chloro-3-fluoroaniline manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 4-Chloro-3-fluoroaniline 367-22-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-06

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Chloro-3-fluoroaniline 367-22-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20t
Release date: 2024-06-18

Henan Fengda Chemical Co., Ltd

Product: 4-Chloro-3-fluoroaniline 367-22-6
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

367-22-6, 4-Chloro-3-fluoroanilineRelated Search:

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3-FLUORO-4-CHLOROANILINE

BUTTPARK 44\01-97

4-chloro-3-fluorobenzenaMine

4-Chloro-3-fluoroanline

4-Chloro-3-fluoroaniline 98%

4-Chloro-3-fluoroaniline98%

Fluoro-4-chloroaniline

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Gefitinib Impurity 96

4-Chloro-3-fluoroaniline ISO 9001：2015 REACH

367-22-6

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