ChemicalBook > CAS DataBase List > 4,6-Dichloronicotinic acid

4,6-Dichloronicotinic acid

Product Name
4,6-Dichloronicotinic acid
CAS No.
73027-79-9
Chemical Name
4,6-Dichloronicotinic acid
Synonyms
4,6-DichloronicotinicAci;4,6-DICHLORONICOTINIC ACID;2,4-Dichloro-5-carboxypyridine;2,4-DICHLORO-5-CARBOXYLPYRIDINE;4,6-Dichloronicotinic acid ,97%;2,4-Dichloro-5-carboxylpyridine ,97%;4,6-Dichloronicotinic Acid(WX614282);4,6-Dichloropyridin-3-carboxylic acid;2,4-Dichloro-5-pyridinecarboxylic acid;4,6-DICHLOROPYRIDINE-3-CARBOXYLIC ACID
CBNumber
CB5449682
Molecular Formula
C6H3Cl2NO2
Formula Weight
192
MOL File
73027-79-9.mol
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4,6-Dichloronicotinic acid Property

Melting point:
158-160
Boiling point:
337.0±37.0 °C(Predicted)
Density 
1.612±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
1.87±0.25(Predicted)
form 
Solid
color 
White to Light yellow
Water Solubility 
Slightly soluble in water.
Stability:
Hygroscopic
InChI
InChI=1S/C6H3Cl2NO2/c7-4-1-5(8)9-2-3(4)6(10)11/h1-2H,(H,10,11)
InChIKey
ILMIEWNDXAKVNI-UHFFFAOYSA-N
SMILES
C1=NC(Cl)=CC(Cl)=C1C(O)=O
CAS DataBase Reference
73027-79-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22-20/21/22
Safety Statements 
24/25-36/37
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D5311
Product name
4,6-Dichloronicotinic Acid
Purity
>98.0%(T)
Packaging
1g
Price
$30
Updated
2025/07/31
TCI Chemical
Product number
D5311
Product name
4,6-Dichloronicotinic Acid
Purity
>98.0%(T)
Packaging
5g
Price
$118
Updated
2025/07/31
TRC
Product number
D435638
Product name
4,6-Dichloronicotinic Acid
Packaging
1g
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD52890
Product name
4,6-Dichloronicotinic acid
Packaging
10g
Price
$75
Updated
2021/12/16
Oakwood
Product number
062528
Product name
4,6-Dichloronicotinic Acid
Purity
97%
Packaging
1g
Price
$13
Updated
2021/12/16
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4,6-Dichloronicotinic acid Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

4,6-Dichloronicotinic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields.

Synthesis

40296-46-6

73027-79-9

General procedure for the synthesis of 4,6-dichloronicotinic acid from ethyl 4,6-dichloronicotinate: to a stirred solution of ethyl 4,6-dichloronicotinate (22) (25.95 g, 118 mmol) dissolved in 4:1:1 THF:MeOH:water (600 mL) was added sodium hydroxide solution (40 mL, 6.25 M). After 30 min of reaction, the reaction mixture was acidified to pH 2 with concentrated hydrochloric acid and subsequently diluted with 1:1 EtOAc:Et2O and washed sequentially with water and brine. The organic layer was dried over anhydrous sodium sulfate and concentrated. The resulting off-white solid was purified by concentrating twice from toluene to give the final target product 4,6-dichloronicotinic acid (23) as a white solid (21.73 g, 96% yield).

References

[1] Patent: US2005/49419, 2005, A1. Location in patent: Page/Page column 24
[2] Patent: US2005/54701, 2005, A1
[3] Tetrahedron Letters, 2011, vol. 52, # 4, p. 512 - 514
[4] Patent: WO2014/52365, 2014, A1. Location in patent: Page/Page column 229-230
[5] Patent: US2015/191464, 2015, A1. Location in patent: Paragraph 0611

4,6-Dichloronicotinic acid Preparation Products And Raw materials

Raw materials

Diethyl 1,3-acetonedicarboxylate Ammonium hydroxide Acetic anhydride Triethyl orthoformate Phosphorus oxitrichloride Hydrochloric acid Sodium hydroxide

Preparation Products

4,6-DICHLORO-PYRIDIN-3-YLAMINE
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4,6-Dichloronicotinic acid Suppliers

Americas 1 China 251 Europe 2 Germany 3 India 7 Japan 1 The Netherlands 1 United Kingdom 5 United States 25 Global 296
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View Lastest Price from 4,6-Dichloronicotinic acid manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
4,6-Dichloronicotinic acid 73027-79-9
Price
US $3.00-9.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-06-27
WUHAN FORTUNA CHEMICAL CO., LTD
Product
4,6-Dichloronicotinic acid 73027-79-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-22
Shaanxi Dideu New Materials Co. Ltd
Product
4,6-Dichloronicotinic acid 73027-79-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-03-10

73027-79-9, 4,6-Dichloronicotinic acidRelated Search:

Clopyralid 6-Chloronicotinic acid 3,4-Dichloropyridine 2',4'-Dichloroacetophenone Zinc picolinate 4-Chloronicotinic acid 2,6-Dichloropyridine 1,2-Dichloro-4-(chloromethyl)benzene Dichloroethane 2,4-Dichlorophenol 2-Picolinic acid 2-Chloro-5-chloromethylpyridine 2-Chloronicotinic acid Thionyl chloride 2,6-Dichloroisonicotinic acid 2,6-Dichloro-5-fluoronicotinic acid Quinclorac 2,5-PYRIDINEDICARBOXYLIC ACID

  • 2,4-DICHLORO-5-PYRIDINE-5-CARBOXYLIC ACID
  • 2,4-DICHLORO-5-CARBOXYLPYRIDINE
  • 2,4-DICHLOROPYRIDINE-5-CARBOXYLIC ACID
  • 4,6-DICHLORONICOTINIC ACID
  • 4,6-DICHLOROPYRIDINE-3-CARBOXYLIC ACID
  • 2,4-Dichloro-5-carboxypyridine
  • 2,4-Dichloro-5-pyridinecarboxylic acid
  • 2,4-Dichloro-5-carboxylpyridine ,97%
  • 4,6-Dichloronicotinic acid ,97%
  • 4,6-Dichloropyridin-3-carboxylic acid
  • 2,4-Dichloropyridine-5-carboxylic acid, 4,6-Dichloropyridine-3-carboxylic acid
  • 4,6-Dichloro-3-pyridinecarboxylic acid
  • 3-Pyridinecarboxylic acid, 4,6-dichloro-
  • 4,6-Dichloronicotinic Acid(WX614282)
  • 4,6-DichloronicotinicAci
  • 4,6-Dichloronicotinic acid ISO 9001：2015 REACH
  • 73027-79-9
  • C5H2Cl2NO2
  • Pyridine
  • Pyridines