4-Methylbenzylsulfonyl chloride
- Product Name
- 4-Methylbenzylsulfonyl chloride
- CAS No.
- 51419-59-1
- Chemical Name
- 4-Methylbenzylsulfonyl chloride
- Synonyms
- 4-Methylbenzylsulfon;4-METHYLBENZYLSULFONYL CHLORIDE;P-TOLYL-METHANESULFONYL CHLORIDE;ɑ-p-Xylenesulfonyl chloride, 97%;^a-p-Xylenesulfonyl chloride, 97%;4-Methylbenzylsulfonyl chloride 96%;p-Methyl-α-toluenesulfonyl chloride;alpha-p-Xylenesulfonyl chloride, 97%;alpha-p-Xylenesulfonyl chloride, 97%,;4-METHYLBENZENEMETHANESULFONYL CHLORIDE
- CBNumber
- CB5475027
- Molecular Formula
- C8H9ClO2S
- Formula Weight
- 204.67
- MOL File
- 51419-59-1.mol
4-Methylbenzylsulfonyl chloride Property
- Melting point:
- 76-80 °C
- Boiling point:
- 305.2±21.0 °C(Predicted)
- Density
- 1.325±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- Appearance
- White to off-white Solid
- Sensitive
- Moisture Sensitive
- CAS DataBase Reference
- 51419-59-1(CAS DataBase Reference)
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 22-34
- Safety Statements
- 26-28-36/37/39-45
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29049090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 664766
- Product name
- 4-Methylbenzylsulfonyl chloride
- Purity
- 96%
- Packaging
- 1g
- Price
- $69.9
- Updated
- 2025/07/31
- Product number
- M291470
- Product name
- 4-Methylbenzylsulfonyl chloride
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 021361
- Product name
- 4-Methylbenzylsulfonyl chloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $48
- Updated
- 2021/12/16
- Product number
- 020886
- Product name
- p-Tolylmethanesulfonylchloride
- Purity
- 95%
- Packaging
- 1g
- Price
- $38
- Updated
- 2021/12/16
- Product number
- 021361
- Product name
- 4-Methylbenzylsulfonyl chloride
- Purity
- 97%
- Packaging
- 5g
- Price
- $155
- Updated
- 2021/12/16
4-Methylbenzylsulfonyl chloride Chemical Properties,Usage,Production
Uses
4-Methylbenzylsulfonyl chloride is a useful reactant for the synthesis of (R)-1-alkyl-substituted tetrahydro-ss-carbolines.
Synthesis Reference(s)
Tetrahedron Letters, 25, p. 4553, 1984 DOI: 10.1016/S0040-4039(01)81491-X
Synthesis
940-63-6
51419-59-1
GENERAL METHOD: Alkyl halide (or sulfate) (5 mmol) was heated at reflux with thiourea (0.381 g, 5 mmol) in ethanol (5 mL) for 1 hour. Upon completion of the reaction, the solvent was removed under vacuum and the residue was washed with ether (3 x 5 mL) to afford the corresponding S-alkyl isothiourea salt as a white solid in near quantitative yield. Without further purification, the resulting product was transferred to a three-necked round-bottomed flask equipped with a thermometer and a charging funnel and placed in an ice bath. Water (0.45 mL) and acetonitrile (10 mL) were then added. A solution of tert-butyl hypochlorite (2.86 mL) in acetonitrile (5 mL) was added slowly and dropwise to the mixture under vigorous stirring, controlling the reaction temperature in the range of 0-20°C. After the dropwise addition, the reaction mixture was continued to be stirred for 30 minutes. At the end of the reaction, the solvent was removed under vacuum, ether (15 mL) was added to dissolve the residue, the organic phase was washed with water (2 x 10 mL), dried over anhydrous sodium sulfate, and finally concentrated under vacuum to give high purity 4-methylbenzylsulfonyl chloride. The product can be further purified by petroleum ether-ethyl acetate mixed solvent recrystallization.
References
[1] Synthesis (Germany), 2015, vol. 47, # 20, p. 3186 - 3190
[2] European Journal of Organic Chemistry, 2012, # 26, p. 5028 - 5037,10
[3] European Journal of Organic Chemistry, 2012, # 26, p. 5028 - 5037
[4] Journal of the American Chemical Society, 1987, vol. 109, # 24, p. 7472 - 7477
[5] Synthesis (Germany), 2013, vol. 45, # 12, p. 1675 - 1682
4-Methylbenzylsulfonyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Methylbenzylsulfonyl chloride manufacturers
- Product
- (4-Methylphenyl)methanesulfonyl chloride 51419-59-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 0.98
- Supply Ability
- 1000
- Release date
- 2024-07-19
- Product
- 4-Methylbenzylsulfonyl chloride 51419-59-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-19
- Product
- (4-Methylphenyl)methanesulfonyl chloride 51419-59-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10