Uses
ChemicalBook > CAS DataBase List > Dansyl chloride

Dansyl chloride

Uses
Product Name
Dansyl chloride
CAS No.
605-65-2
Chemical Name
Dansyl chloride
Synonyms
DNS;dansyl;DNSCL;5-DIMETHYLAMINO-1-NAPHTHALENESULFONYL CHLORIDE;SKL100;AI301174;AI3 01174;AI3-01174;DNS chloride;ansylchloride
CBNumber
CB5696240
Molecular Formula
C12H12ClNO2S
Formula Weight
269.75
MOL File
605-65-2.mol
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Dansyl chloride Property

Melting point:
72-74 °C(lit.)
Boiling point:
371.3±22.0 °C(Predicted)
Density 
1.1702 (rough estimate)
refractive index 
1.5630 (estimate)
storage temp. 
2-8°C
solubility 
acetone: 50 mg/mL
form 
powder and chunks
pka
2.38±0.40(Predicted)
color 
yellow to orange
Water Solubility 
Soluble in dimethyl fluoride, acetone, chloroform, pyridine, benzene and dioxane. Insoluble in water.
Sensitive 
Moisture Sensitive
Merck 
14,2814
BRN 
2217205
Stability:
Hygroscopic, Moisture Sensitive
InChIKey
XPDXVDYUQZHFPV-UHFFFAOYSA-N
CAS DataBase Reference
605-65-2(CAS DataBase Reference)
EPA Substance Registry System
1-Naphthalenesulfonyl chloride, 5-(dimethylamino)- (605-65-2)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45-3
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
RTECS 
QK3688000
F 
10-21
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29214980
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
39220
Product name
Dansyl chloride
Purity
BioReagent, suitable for fluorescence, ≥99.0% (HPLC)
Packaging
1g
Price
$119
Updated
2024/03/01
Sigma-Aldrich
Product number
39220
Product name
Dansyl chloride
Purity
BioReagent, suitable for fluorescence, ≥99.0% (HPLC)
Packaging
5G
Price
$481
Updated
2024/03/01
Sigma-Aldrich
Product number
39220
Product name
Dansyl chloride
Purity
BioReagent, suitable for fluorescence, ≥99.0% (HPLC)
Packaging
50g
Price
$2450
Updated
2024/03/01
Sigma-Aldrich
Product number
03641
Product name
Dansyl chloride
Purity
for HPLC derivatization, ≥99.0% (HPLC)
Packaging
100mg
Price
$47.3
Updated
2024/03/01
Sigma-Aldrich
Product number
311155
Product name
Dansyl Chloride - CAS 605-65-2 - Calbiochem
Purity
Reagent used for fluorescent labeling of proteins, N-terminal amino acids, and amines.
Packaging
1G
Price
$77.6
Updated
2024/03/01
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Dansyl chloride Chemical Properties,Usage,Production

Uses

Dansyl chloride or 5-Dimethylaminonaphthalene-1-sulfonyl chloride (CAS 605-65-2) is a fluorogenic reagent used for protein, N-terminal amino acid and peptide detection by reverse phase high performance liquid chromatography (HPLC). It is also used to determine the degree of labeling in chymotrypsin and ovalbumin. It acts as a precursor for the synthesis of other derivatives like dansyl amide.
Dansyl chloride is non-fluorescent until it reacts with amines. The resulting Dansyl amides have environmentally sensitive fluorescence quantum yields and emission maxima along with large Stokes shifts. This environment-sensitive fluorescence property has made Dansyl chloride an important tool for biophysical studies.

Chemical Properties

yellow to orange-yellow crystalline powder

Uses

A fluorogenic reagent for N-terminal derivatization of amino acids and peptides and detection by reverse phase HPLC.

Uses

Dansyl chloride is a fluorogenic reagent used for protein, N-terminal amino acid and peptide detection by reverse phase high performance liquid chromatography (HPLC). It is also used to determine the degree of labeling in chymotrypsin and ovalbumin. It acts as a precursor for the synthesis of other derivatives like dansyl amide.

Uses

Reagent for fluorescent labelling of amines, amino acids and proteins.

Uses

In fluorescent labelling, column chromatography, HPLC.

Definition

ChEBI: Dansyl chloride is an aminonaphthalene and a sulfonic acid derivative.

General Description

Dansyl chloride is a fluorogenic reagent which is typically employed for the derivatization of amino acids.

Biochem/physiol Actions

Dansyl chloride is a sulfonyl chloride compound. It is used to end tag amino groups of peptides and proteins. Dansyl chloride is used for derivatization of free amino acids and amines in neural samples and biological fluids. It is used to study fluorescent conjugates of albumin, protein conformational changes studies and active site characterization.

Safety Profile

Poison by intravenous route, When heated to decomposition it emits very toxic fumes of Cland NOx

Dansyl chloride Preparation Products And Raw materials

Raw materials

Phosphorus pentachloride Diethyl ether Ethyl acetate Hydrochloric acid Sodium bicarbonate 5-Amino-1-naphthalenesulfonic acid Silicon dioxide PETROLEUM ETHER Dimethyl sulfate

Preparation Products

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View Lastest Price from Dansyl chloride manufacturers

Honest Joy Holdings Limited
Product
5-(Dimethylamino)naphthalene-1-sulfonyl chloride 605-65-2
Price
US $0.00/KG
Min. Order
1KG
Purity
98.8%
Supply Ability
100 tons
Release date
2022-02-21
Career Henan Chemical Co
Product
Dansyl chloride 605-65-2
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200kg
Release date
2018-12-25

605-65-2, Dansyl chlorideRelated Search:

N-Acetylsulfanilyl chloride Naphthalene Sulfuryl chloride Pivaloyl chloride Ferric chloride Tosyl chloride Choline chloride N,N-Dimethyl-1,4-phenylenediamine 2,6-DIMETHYLNAPHTHALENE 1-Naphthalenesulfonyl chloride Sodium chloride Polyvinyl chloride Benzenesulfonyl chloride Chloroacetyl chloride Calcium chloride 3-Dimethylaminopropylamine Ammonium chloride Potassium chloride

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  • AI3 01174
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