Benzamidine hydrochloride

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Benzamidine hydrochloride

Product Name: Benzamidine hydrochloride
CAS No.: 1670-14-0
Chemical Name: Benzamidine hydrochloride
Synonyms: BenziMidaMide hydrochloride;BENZAMIDINE HCL;benzamidine hydroxychloride;s-dimethylester;BENZAMIDE HCL H2O;Benzamidine hydrochl;benzamidiniumchloride;BENZAMIDINE HYDROCHLORIDE;Benzamidin Hydrochloride;amidinobenzenehydrochloride
CBNumber: CB6100733
Molecular Formula: C7H9ClN2
Formula Weight: 156.61
MOL File: 1670-14-0.mol

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Benzamidine hydrochloride Property

Melting point:: 86-88 °C(lit.)
storage temp.: 2-8°C
solubility: DMF: 25 mg/ml
DMSO: 25 mg/ml
Ethanol: 10 mg/ml
PBS (pH 7.2): 3 mg/ml
form: Powder
color: White to off-white
PH: 4.0 to 6.5(50g/L, 25 ℃)
Water Solubility: soluble
BRN: 3594959
Stability:: Stable for 2 years from date of purchase as supplied. Solutions are not stable and must be prepared fresh daily
InChIKey: LZCZIHQBSCVGRD-UHFFFAOYSA-N
CAS DataBase Reference: 1670-14-0(CAS DataBase Reference)
EPA Substance Registry System: Benzenecarboximidamide, monohydrochloride (1670-14-0)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39-36
WGK Germany: 3
RTECS: CV6260000
F: 3-21
HS Code: 29252900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 63226
Product name: Benzamidine hydrochloride 1 M solution
Packaging: 1mL
Price: $73.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: 199001-M
Product name: Benzamidine, Hydrochloride
Purity: Inhibitor of trypsin and trypsin-like enzymes.
Packaging: 25gm-m
Price: $101
Updated: 2021/12/16

Sigma-Aldrich

Product number: 199001-M
Product name: Benzamidine, Hydrochloride - CAS 1670-14-0 - Calbiochem
Purity: Inhibitor of trypsin and trypsin-like enzymes.
Packaging: 25g
Price: $101
Updated: 2021/12/16

Sigma-Aldrich

Product number: 199001-M
Product name: Benzamidine, Hydrochloride
Purity: Inhibitor of trypsin and trypsin-like enzymes.
Packaging: 5gm-m
Price: $55.7
Updated: 2021/12/16

Sigma-Aldrich

Product number: 199001-M
Product name: Benzamidine, Hydrochloride - CAS 1670-14-0 - Calbiochem
Purity: Inhibitor of trypsin and trypsin-like enzymes.
Packaging: 5G
Price: $55.7
Updated: 2021/12/16

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Benzamidine hydrochloride Chemical Properties,Usage,Production

Description

Benzamidine hydrochloride is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases. A concentration of approximately 1 mM is used for general protease inhibition. To inhibit proteases from yeast, a range of 0.5 to 4.0 mM is used and it is for the most part interchangeable with pepstatin A.
In addition to being a strong competitive inhibitor of trypsin, benzamidine HCl has been also shown to be a strong competitive inhibitor of thrombin and plasmin. It was also found to be as effective as aprotinin in the prevention of glucagon degradation in human plasma.

Chemical Properties

white to off-white powder

Uses

Benzamidine is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Kis = 35, 350, and 220 μM, respectively). In addition to its use as a general serine protease inhibitor, benzamidine is used, when immobilized, to purify novel proteases.

Preparation

To a stainless steel rocking autoclave equipped with a stirrer is added 103.0 gm (1.0 mole) of benzonitrile, 214.0 gm (4.0 mole) of ammonium chloride, and 306.0 gm (18.0 mole) of ammonia is introduced by means of a transfer bomb. The reaction mixture is heated at 150°C for 18 hr (pressure: 1300-6500 psig), cooled, and, with appropriate precautions for the safe control of the excess ammonia, is vented to atmospheric pressure. The reaction mixture is extracted with ether to remove approximately 5% unreacted benzonitrile, and then extracted with hot acetonitrile or ethanol to separate the amidine hydrochloride from the unreacted ammonium chloride. Concentration of the latter affords 120.5 gm (77%) of benzamidine hydrochloride, m.p. 161-163°C.

Biological Activity

Benzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 μM, 21 μM, 20 μM and 110 μM for uPA, trypsin, tryptase and factor Xa, respectively.

Safety Profile

Moderately toxic byintraperitoneal route. When heated to decomposition itemits toxic vapors of NOx, HCl, and Cl^-.

in vitro

Benzamidine hydrochloride has weak inhibition for tPA and thrombin, with Kis of 750 μM and 320 μM, respectively.

References

1) Markwardt?et al. (1968)?Comparative studies on the inhibition of trypsin, plasmin, and thrombin by derivatives of benzylamine and benzamide; Eur. J. Biochem.,?6?502 2) Deutscher?et al.?(1990),?Maintaining protein stability; Methods Enzymol.,?182?83 3) Jaswinski?et al.?(1990),?Preparations of extracts from yeast; Methods Enzymol.,?182?154 4) Ensinck?et al.?(1972),?Use of Benzamidine as a proteolytic inhibitor in the radioimmunoassay of glucagon in plasma; J. Clin. Endocrinol. Metab.,?35?463 5) Jeffcoate?et al. (1974),?Use of benzamidine to prevent the destruction of thyrotropin-releasing hormone (TRH) by blood; Endocrinol. Metab,?38?155

Benzamidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

2-PHENYL-4-[3H]QUINAZOLINONE Ethyl 4-hydroxy-2-phenylpyrimidine-5-carboxylate 4-CHLORO-2-PHENYLQUINAZOLINE 2-PHENYLPYRIMIDINE 4-CHLORO-6-METHYL-2-PHENYL-PYRIMIDINE 4-HYDROXY-2-PHENYL-5-PYRIMIDINECARBOXYLIC ACID

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View Lastest Price from Benzamidine hydrochloride manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Benzamidine hydrochloride 1670-14-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-16

Shaanxi Dideu Medichem Co. Ltd

Product: Benzamidine hydrochloride 1670-14-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2019-12-31

Zhuozhou Wenxi import and Export Co., Ltd

Product: Benzamidine hydrochloride 1670-14-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

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