ChemicalBook > CAS DataBase List > Ethyl 4,6-dichloronicotinate
Ethyl 4,6-dichloronicotinate
Uses- Product Name
- Ethyl 4,6-dichloronicotinate
- CAS No.
- 40296-46-6
- Chemical Name
- Ethyl 4,6-dichloronicotinate
- Synonyms
- ethyl 4,6-dichloropyridine-3-carboxylate;Novobiocin Impurity 5;Ethyl 4,6-dichloronitinate;Ethy14,6-dichloronicotinate;ETHYL 4,6-DICHLORONICOTINATE;Ethyl 4,6-dicholoronicotinate;Ethyl 4,6-Dichloronicotinate >Ethyl 4,6-dichloronicotinate ,97%;ethyl 4,6-dichloronicotinate (en);2,4-Dichloro-5-carbethoxypyridine
- CBNumber
- CB6102429
- Molecular Formula
- C8H7Cl2NO2
- Formula Weight
- 220.05
- MOL File
- 40296-46-6.mol
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Ethyl 4,6-dichloronicotinate Property
- Melting point:
- 32-34°
- Boiling point:
- 85°C/0.01mmHg(lit.)
- Density
- 1.367±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Soluble in methanol.
- pka
- -1.24±0.10(Predicted)
- form
- Liquid
- color
- Yellow
- InChI
- InChI=1S/C8H7Cl2NO2/c1-2-13-8(12)5-4-11-7(10)3-6(5)9/h3-4H,2H2,1H3
- InChIKey
- AAUBVINEXCCXOK-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=CC(Cl)=C1C(OCC)=O
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- E1068
- Product name
- Ethyl 4,6-Dichloronicotinate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $17
- Updated
- 2025/07/31
TCI Chemical
- Product number
- E1068
- Product name
- Ethyl 4,6-Dichloronicotinate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $54
- Updated
- 2025/07/31
TRC
- Product number
- E915915
- Product name
- Ethyl 4,6-Dichloronicotinate
- Packaging
- 25g
- Price
- $250
- Updated
- 2021/12/16
TRC
- Product number
- E915915
- Product name
- Ethyl 4,6-Dichloronicotinate
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 046094
- Product name
- Ethyl 4,6-dichloronicotinate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $44
- Updated
- 2021/12/16
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Ethyl 4,6-dichloronicotinate Chemical Properties,Usage,Production
Uses
Ethyl 4,6-Dichloronicotinate acts as a reactant in the preparation of (acylamino)aminonaphthyridinones as novobiocin analogs and Hsp90 inhibitors, their antitumor activities in human breast cancer cell lines, and the effects on aptoptosis and cell cycle advancement of selected compounds.
Chemical Properties
White solid
Uses
Ethyl 4,6-dichloronicotinate is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals, and dyestuffs. It is also used as a fine chemical intermediate. Ethyl-4,6-dichloronicotinate could be used as a starting material to synthesize 6-chlorothieno[3,2-c]pyridine-2-carbohydrazide-hydrazone subsidiaries[1].
Synthesis
6975-44-6
40296-46-6
The general procedure for the synthesis of ethyl 4,6-dichloronicotinate from ethyl 4,6-dihydroxynicotinate was as follows: ethyl 4,6-dihydroxynicotinate (60 g, 0.328 mol) was slowly added to phosphorus triclosan (POCl3, 500 mL), followed by heating and refluxing for 2 hours. Upon completion of the reaction, the excess phosphorous trichloride was removed by distillation under reduced pressure. The residue was carefully poured into ice water, stirred for 30 min, and then extracted with ethyl acetate (EtOAc, 3 times). The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate (MgSO4) and finally concentrated under vacuum to give ethyl 4,6-dichloronicotinate (65 g, 90% yield). The product was identified by 1H NMR (300 MHz, DMSO-d6): δ 8.80 (s, 1H), 7.95 (s, 1H), 4.34 (q, J=6.9 Hz, 2H), 1.31 (t, J=6.9 Hz, 3H); Mass Spectra (ESI) m/z: 220.1 [M+H]+.
References
[1] N. Rao, K. Prasad, M. Rao. “Synthesis and Antibacterial Evaluation of Hydrazone Derivatives Bearing 6-Chlorothieno[3,2-c]pyridine Moiety.” Asian Journal of Chemistry 1 1 (2019).
Ethyl 4,6-dichloronicotinate Preparation Products And Raw materials
Raw materials
Diethyl 1,3-acetonedicarboxylate
Ammonium hydroxide
Ethanol
Acetic anhydride
Triethyl orthoformate
Phosphorus oxitrichloride
Hydrochloric acid
Sodium hydroxide
Preparation Products
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View Lastest Price from Ethyl 4,6-dichloronicotinate manufacturers
Shaanxi Dideu New Materials Co. Ltd
- Product
- Ethyl 4,6-dichloronicotinate 40296-46-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-11-13
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- Ethyl 4,6-dichloronicotinate 40296-46-6
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-25
Henan Aochuang Chemical Co.,Ltd.
- Product
- Ethyl 4,6-dichloronicotinate 40296-46-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27
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