ChemicalBook > CAS DataBase List > 2,6-Dichloroisonicotinic acid

2,6-Dichloroisonicotinic acid

Product Name
2,6-Dichloroisonicotinic acid
CAS No.
5398-44-7
Chemical Name
2,6-Dichloroisonicotinic acid
Synonyms
2,6-DICHLOROPYRIDINE-4-CARBOXYLIC ACID;CGA-41396;BUTTPARK 43\57-46;AKOS BBS-00006615;RARECHEM AL BO 0824;TIMTEC-BB SBB003621;2,6-dichloroisonicotinicaci;2,6-DICHLOROISONICOTINIC ACID;Dichloropyridinecarboxylicacid;2,6-DichloroisonicotinicAcid>
CBNumber
CB6110923
Molecular Formula
C6H3Cl2NO2
Formula Weight
192
MOL File
5398-44-7.mol
More
Less

2,6-Dichloroisonicotinic acid Property

Melting point:
209-212 °C(lit.)
Boiling point:
437.8±40.0 °C(Predicted)
Density 
1.612±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
2.63±0.10(Predicted)
color 
White to Brown
Water Solubility 
insoluble
InChI
InChI=1S/C6H3Cl2NO2/c7-4-1-3(6(10)11)2-5(8)9-4/h1-2H,(H,10,11)
InChIKey
SQSYNRCXIZHKAI-UHFFFAOYSA-N
SMILES
C1(Cl)=NC(Cl)=CC(C(O)=O)=C1
CAS DataBase Reference
5398-44-7(CAS DataBase Reference)
NIST Chemistry Reference
4-Pyridinecarboxylic acid, 2,6-dichloro-(5398-44-7)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
456543
Product name
2,6-Dichloropyridine-4-carboxylic acid
Purity
98%
Packaging
1g
Price
$14.56
Updated
2024/03/01
Sigma-Aldrich
Product number
456543
Product name
2,6-Dichloropyridine-4-carboxylic acid
Purity
98%
Packaging
5g
Price
$133
Updated
2024/03/01
TCI Chemical
Product number
D3345
Product name
2,6-Dichloroisonicotinic Acid
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$29
Updated
2024/03/01
TCI Chemical
Product number
D3345
Product name
2,6-Dichloroisonicotinic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$82
Updated
2024/03/01
Alfa Aesar
Product number
B20541
Product name
2,6-Dichloropyridine-4-carboxylic acid, 98%
Packaging
5g
Price
$121.65
Updated
2024/03/01
More
Less

2,6-Dichloroisonicotinic acid Chemical Properties,Usage,Production

Chemical Properties

off-white to beige or light brownish powder

Uses

2,6-Dichloroisonicotinic acid is a derivative of isonicotinic acid (I821760). Treatment of oat cultivars using 2,6-dichloroisonicotinic acid results in an increased accumulation of avenathramide. 2,6-Dichloroisonicotinic acid is a well known inducer of plant resistance and induces the transcription of ZmNAC100 transcription factor.

Definition

ChEBI: A member of the class of pyridines that is isonicotinic acid which is substituted by chlorine at positions 2 and 6.

Agricultural Uses

The best characterized synthetic inducer of resistance, 2,6-dichloroisonicotinic acid and its methyl ester (both are referred to as INA) were the first synthetic compounds reported to activate a phenocopy of bonafide systemic acquired resistance (SAR). 2,6-dichloroisonicotinic acid was used as an abiotic resistance inducer against bacterial spot disease of tomato caused by Xanthomonas perforans. INA was found to protect cucumber, tobacco, arabidopsis, sugar beet, bean, rose, barley, and rice from several pathogens[1].

Mode of action

In tobacco, salicylic acid (SA) and 2,6-dichloroisonicotinic acid (INA) induce the same nine classes of genes (including the PR genes) that are expressed systemically after tobacco mosaic virus (TMV) infection. In contrast to many other abiotic inducers of PR gene expression and enhanced disease resistance, such as polyacrylic acid and thiamine, INA does not stimulate the accumulation of SA or its glucoside in treated tobacco plants. The strong correlation between biological activity and the ability to bind and inhibit catalase suggests that the physiological effects of INA, SA, and their active analogs are mediated by the same mechanism of action: inhibition of catalase's ability to degrade H202[2].

References

[1] S. Chandrashekar, S. Umesha. “2,6-Dichloroisonicotinic acid enhances the expression of defense genes in tomato seedlings against Xanthomonas perforans.” Physiological and Molecular Plant Pathology 86 (2014): Pages 49-56.
[2] Uwe Conrath. “Two inducers of plant defense responses, 2,6-dichloroisonicotinec acid and salicylic acid, inhibit catalase activity in tobacco.” Proceedings of the National Academy of Sciences of the United States of America 92 16 1 (1995): 7143–7.

2,6-Dichloroisonicotinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

2,6-DICHLORO-4-ISOCYANATOPYRIDINE 2,6-Dichloropyridine-4-carboxaldehyde 3,5-BIS(METHYLSULFONYL)ANILINE
More
Less

2,6-Dichloroisonicotinic acid Suppliers

Americas 1 Belgium 2 Canada 3 China 250 Europe 3 France 1 Germany 4 India 17 Japan 3 Poland 1 South Korea 1 Switzerland 3 The Netherlands 2 Ukraine 1 United Kingdom 16 United States 49 Global 357
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Accela ChemBio Inc.
Tel
+1-858-6993322
Fax
(+1)-858-876-1948
Email
info@accelachem.com
Country
United States
ProdList
17322
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
Panslavia Chemicals
Tel
--
Fax
--
Country
United States
ProdList
121
Advantage
58
Chemphtec Corporation
Tel
--
Fax
--
Email
fo@chemphtec.com
Country
United States
ProdList
2181
Advantage
58
AstaTech, Inc.
Tel
--
Fax
--
Email
sales@astatechinc.com
Country
United States
ProdList
904
Advantage
58
Tyger Scientific Inc.
Tel
--
Fax
--
Email
sales@tygersci.com
Country
United States
ProdList
402
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
Chiral Management
Tel
--
Fax
--
Email
sales@chiralmanagement.com
Country
United States
ProdList
1332
Advantage
30
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
Advanced Chemical Intermediates Ltd.
Tel
--
Fax
--
Email
enquiries@acints.com
Country
United States
ProdList
4893
Advantage
58
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
HBCChem, Inc.
Tel
--
Fax
--
Email
Sales@hbcchem-inc.com
Country
United States
ProdList
887
Advantage
50
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
Anvia Chemicals, LLC
Tel
--
Fax
--
Email
sales@anviachem.com
Country
United States
ProdList
3933
Advantage
0
True Pharmachem Inc.
Tel
--
Fax
--
Email
sales@truepharmachem.com
Country
United States
ProdList
226
Advantage
60
Wilshire Chemical Company Inc.
Tel
--
Fax
--
Email
WilshrChem@AOL.COM
Country
United States
ProdList
3498
Advantage
58
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
Aagile Labs Division of Tyger Scientific
Tel
--
Fax
--
Email
tygersci@yahoo.com
Country
United States
ProdList
6568
Advantage
68
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Anthem Pharmaceutical Research LLC
Tel
--
Fax
--
Email
sales@anthempharma.com
Country
United States
ProdList
3040
Advantage
30
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Ryan Scientific, Inc.
Tel
--
Fax
--
Email
ryan.reichlyn@ryansci.com
Country
United States
ProdList
6439
Advantage
60
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
Sinova Inc.
Tel
--
Fax
--
Email
sales@sinovainc.com
Country
United States
ProdList
4009
Advantage
58
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
Carbocore, Inc.
Tel
--
Fax
--
Email
sales@carbocore.com
Country
United States
ProdList
1436
Advantage
60
AstaTech, Inc
Tel
--
Fax
--
Email
sales@astatechinc.com
Country
United States
ProdList
6371
Advantage
58
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
Acros Organics USA
Tel
--
Fax
--
Email
eveleth@fisherchem.com
Country
United States
ProdList
3846
Advantage
81
M/S PANAMIT INTERNATIONAL
Tel
--
Fax
--
Email
sales@jyotichem.com
Country
United States
ProdList
312
Advantage
46
Ram-Nath
Tel
--
Fax
--
Country
United States
ProdList
41
Advantage
64
TimTec Corporation
Tel
--
Fax
--
Email
info@timtec.net
Country
United States
ProdList
6891
Advantage
68
Ennova MedChem Group Inc., formerly Arch Corporation
Tel
--
Fax
--
Email
sales@ennovamedchem.com
Country
United States
ProdList
1218
Advantage
42
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
Biogene Organics Inc.
Tel
--
Fax
--
Email
sales@biogeneorganics.com
Country
United States
ProdList
1119
Advantage
39
More
Less

View Lastest Price from 2,6-Dichloroisonicotinic acid manufacturers

Enki Biopharmaceuticals (Shanghai) Limited
Product
2,6-Dichloroisonicotinic acid 5398-44-7
Price
US $0.00-0.00/kg
Min. Order
5kg
Purity
99.0%
Supply Ability
1000
Release date
2023-11-25
Watson Biotechnology Co.,Ltd
Product
2,6-Dichloroisonicotinic Acid 5398-44-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2024-08-15
Dideu Industries Group Limited
Product
2,6-Dichloroisonicotinic acid 5398-44-7
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-25

5398-44-7, 2,6-Dichloroisonicotinic acidRelated Search:

1,2-Dichloroethane 2,6-Dichloro-5-fluoronicotinic acid Sodium dichloroisocyanurate 3-Chloroisonicotinic acid Isonicotinic acid DICHLOROISOCYANURIC ACID Diisopropylammonium dichloroacetate 2-Chloro-4-pyridinecarboxylic acid 1,3-Dichloro-1,3,5-triazinetrione,sodium salt METHYL 2,6-DICHLOROISONICOTINATE 2,6-Dichloroisonicotinic acid tert-butyl ester,2,6-Dichloroisonicotinic Acid t-butyl ester 2-BROMO-3,5-DICHLOROISONICOTINIC ACID 2,5-DICHLOROISONICOTINIC ACID 2,3-DICHLOROISONICOTINIC ACID 3,5-Dichloroisonicotinic acid(3,5-Dichloropyridine-4-carboxylic acid),3,5-DICHLOROISONICOTINIC ACID 2,6-Dichloropyridine 2,3,5,6-Tetrachloropyridine-4-carboxylic acid Ethyl 2,6-dichloroisonicotinate

  • 2,6-Dichloroisonicotinic acid ,98%
  • CGA-41396
  • 2,6-Dichloropyridine-4-carboxylic acid,2,6-Dichloroisonicotinic acid
  • 2,6-Dichloropyridine-4-carboxylic acid, 4-Carboxy-2,6-dichloropyridine
  • 2,6-Dichloropyridine-4-carboxylic acid 98%
  • 2,6-Dichloropyrdine-4-carboxylic acid
  • 4-Pyridinecarboxylic acid, 2,6-dichloro-
  • BUTTPARK 43\57-46
  • 2,6-DICHLOROPYRIDINE-4-CARBOXYLIC ACID
  • 2,6-DICHLOROISONICOTINIC ACID
  • 2,6-DICHLORO-4-PYRIDINECARBOXYLIC ACID
  • 2,6-DICHLORO-4-PYRIDINYL CARBOXYLIC ACID
  • RARECHEM AL BO 0824
  • TIMTEC-BB SBB003621
  • AKOS BBS-00006615
  • Pyridine-4-carboxilic acid, 2, 6-dichloro-
  • Pyridine-4-carboxylic acid, 2,6-dichloro-
  • Dichloropyridinecarboxylicacid
  • 2,6-DichloroisonicotinicAcid&gt
  • 2,6-Dichloroisonicotinic acid (2,6-Dichloropyridine-4-carboxylic acid)
  • 2,6-dichloroisonicotinicaci
  • 2,6-Dichloroisonicotinic acid ISO 9001：2015 REACH
  • 5398-44-7
  • C6H3Cl2NO2
  • Building Blocks
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Pyridines
  • Halopyridines
  • Chloropyridines
  • Intermediate of Irinotecan
  • Pyridines
  • Pyridine
  • Chloropyridines
  • Halopyridines
  • Carboxylic Acids
  • pharmacetical
  • Carboxylic Acids