4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride

Product Name: 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride
CAS No.: 28783-41-7
Chemical Name: 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride
Synonyms: 4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE HYDROCHLORIDE;Clopidogrel-7;2-c]pyridine HCl;7-Tetrahydrothieno[3;Pragrace Impurity 23;Zidovudine impurity F;Clopidogrel Impurity 56;Clopidogrel Impurities6;Clopidogrel Impurities195;Prasugrel Impurity 23 HCl
CBNumber: CB6122076
Molecular Formula: C7H9NS
Formula Weight: 139.22
MOL File: 28783-41-7.mol

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4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride Property

Melting point:: 212-215°C
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO, Methanol, Water
form: Solid
color: White to Off-White
Major Application: pharmaceutical
InChI: InChI=1S/C7H9NS/c1-3-8-5-6-2-4-9-7(1)6/h2,4,8H,1,3,5H2
InChIKey: OGUWOLDNYOTRBO-UHFFFAOYSA-N
SMILES: C12CNCCC=1SC=C2
CAS DataBase Reference: 28783-41-7(CAS DataBase Reference)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-37
RIDADR: UN2811
WGK Germany: WGK 3
HazardClass: IRRITANT
HS Code: 29333990
Storage Class: 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications: Acute Tox. 3 Oral

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T2770
Product name: 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine Hydrochloride
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $18
Updated: 2025/07/31

TCI Chemical

Product number: T2770
Product name: 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine Hydrochloride
Purity: >98.0%(HPLC)(N)
Packaging: 25g
Price: $50
Updated: 2025/07/31

TRC

Product number: T295750
Product name: 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine Hydrochloride
Packaging: 5g
Price: $120
Updated: 2021/12/16

Usbiological

Product number: T2972-12
Product name: 4,5,6,7-Tetrahydro-thieno[3,2-c]pyridine Hydrochloride
Packaging: 1g
Price: $403
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 13746
Product name: 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine Hydrochloride
Packaging: 5G
Price: $590
Updated: 2021/12/16

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4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

An intemediate of Clopidogrel and Prasugrel.

Synthesis

30433-91-1

50-00-0

28783-41-7

Example 5: Preparation of 4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride In a 2-liter four-necked flask equipped with a thermometer and a mechanical stirrer, 2-thiophene ethylamine (100 g, 0.79 mol) was added. The reaction was dissolved in dichloromethane (600 ml) at 25°C (±5°C) and stirred for 5 to 10 minutes. Subsequently, paraformaldehyde (26.4 g, 0.88 mole) was added to the reaction system and the reaction was subjected to azeotropic reflux at 40 to 45°C for 4 to 6 hours. Upon completion of the reaction, the system was cooled to room temperature and a N,N-dimethylformamide solution (200 ml) of 7% hydrochloric acid was slowly added at 25 °C (±5 °C). The reaction mixture was continued to be stirred at 70°C (±5°C) for 4 to 6 hours. Afterwards, the reaction solution was cooled to 15 °C (±2 °C) and stirred for 8 to 10 hours to promote crystallization. The solid product was collected by filtration and washed with pre-cooled dichloromethane. Finally, the product was dried under vacuum at 30 to 40 °C to afford 4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride (120 g, 99% yield).

References

[1] Patent: WO2012/1486, 2012, A1. Location in patent: Page/Page column 18
[2] Journal of Organic Chemistry, 2015, vol. 80, # 14, p. 7019 - 7032
[3] Patent: EP1772455, 2007, A2. Location in patent: Page/Page column 9
[4] Journal of Organometallic Chemistry, 2009, vol. 694, # 13, p. 2092 - 2095
[5] Patent: US2004/24011, 2004, A1. Location in patent: Page 7

4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride Preparation Products And Raw materials

Raw materials

2-Thiophenecarboxaldehyde Nitromethane Thiophene-2-ethylamine Formaldehyde 1,3-Dioxolane Tetrahydrofuran Ammonium chloride Ethyl acetate Lithium Aluminum Hydride Hydrochloric acid Methanol Isopropyl alcohol Sulfuric acid

Preparation Products

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4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride Suppliers

Canada 1 China 314 Europe 2 Germany 5 India 24 Japan 1 Slovakia 1 South Korea 1 Ukraine 2 United Kingdom 9 United States 36 Global 396

Changzhou Xuanming Pharmaceutical Technology Co., Ltd.

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J & K SCIENTIFIC LTD.

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INTATRADE GmbH

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Alfa Aesar

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Beijing Ouhe Technology Co., Ltd

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View Lastest Price from 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride 28783-41-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

Henan Fengda Chemical Co., Ltd

Product: 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine (hydrochloride) 28783-41-7
Price: US $6.00-0.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-24

Hebei Zhanyao Biotechnology Co. Ltd

Product: 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride 28783-41-7
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-11-04

28783-41-7, 4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochlorideRelated Search:

Tetrahydrothiophene Benzyl chloride 3-Pyridylacetic acid hydrochloride Mepiquat chloride 2,6-Lutidine Ammonium chloride Pyridine Polyvinyl chloride Methoxyammonium chloride Calcium chloride Pyridine hydrochloride Topotecan hydrochloride Pyridinium chlorochromate Tetrahydrothiophen-3-one Sodium chloride Choline chloride L-Lysine hydrochloride D-Glucosamine hydrochloride

4,5,6.7-Tetrahydro-thienol[3,2-c]pyridine HCl

Thieno[3,2-c]pyridine, 4,5,6,7-tetrahydro-, hydrochloride

Clopidogrel Thieno IMpurity

4,5,6,7-Tetrahydrothieno[3,2-c]pyridine hydrochloride, 96%, 96%

TTP 4,5,6,7-Tetrahydrothieno 3,2-c Pyridine

4,5,6,7-tetrahydrothineo [3,2-c]pyridine hydrochloride

4,5,6,7-TETRAHYDROTHIENO[3,2,C] PYRIDINE HCL

4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE HYDROCHLORIDE

4,5,6,7-tetrahydrotieno[3,2-c]pyridinium chloride

4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE HCl(TTP)

4,5,6,7-tetrahydrothieno[3,2-c]pyridinium chloride

Tetrahydrothieno pyridine HCl

4,5,6,7-Tetrahydrothieon[3,2-C]pyridine,HCl

4,5,6,7-Tetrahydrothieon[3,2-C]pyridine,hydrochloride

Thieno[3,2-c]pyridine, 4,5,6,7-tetrahydro-, hydrochloride (1:1)

4,5,6,7-tetrahydrothieno[3,2-c]pyridine(SALTDATA: HCl)

4,5,6,7-Tetrahydrothiophene[3,2-c]pyridine hydrochloride

4,5,6,7-Tetrahydrothieno[3,2-c]pyridine hydrochloride ,98%

6,7-Dihydro-4H-thieno[3,2-c]pyridine Hydrochloride

4,5,6,7-TET RAH YDROTHIENO[3,2-C]PYRIDE

Zidovudine impurity F

2-c]pyridine HCl

7-Tetrahydrothieno[3

Clopidogrel Thienopyridine Impurity

Clopidogrel Impurity 24 HCl

Clopidogrel-7

TTP 4,5,6,7-Tetrahydrothieno[3,2-c]Pyridine HCL

Clopidogrel Thieno Impurity HCl

Pragrace Impurity 23

Clopidogrel Impurity 56

4,5,6,7-Tetrahydrothieno[3,2-c]pyridine hydrochloride (Clopidogrel Impurity)

Clopidogrel Impurities195

Clopidogrel Impurities6

4,5,6,7-Tetrahydrothieno[3,2,-c] pyridine hydrochlorideQ: What is 4,5,6,7-Tetrahydrothieno[3,2,-c] pyridine hydrochloride Q: What is the CAS Number of 4,5,6,7-Tetrahydrothieno[3,2,-c] pyridine hydrochloride Q: What is the storage condition of 4,5,6,7-Tetrahydrothieno[3,2,-c] pyridine hydrochloride Q: What are the applications of 4,5,6,7-Tetrahydrothieno[3,2,-c] pyridine hydrochloride

Al 4,5,6,7 -Teirahydro [3,2-C] Thieno Pyridine Hydrochloride

Tetrahydrothieno pyridine (THTP)

4,5,6,7-Tetrahydrothiopheno[3,2-c] Pyridine HCl (from Route-I)

Clopidogrel EP Impurity 22

Tetrahydrothienopyridine Hydrochloride

Prasugrel Impurity 23 HCl

28783-41-7

C7H9NSClH

C7H9NSHClC7H10ClNS

C7H9SNHCl

C7H9NSHCl

C7H10ClNS

Prasugrel Intermediates

Heterocycle-Pyridine series

Heterocyclic Compounds

Bases & Related Reagents

Heterocycles

Nucleotides

Sulfur & Selenium Compounds

Intermediates