ChemicalBook > CAS DataBase List > 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid

4-(4-Methylpiperazin-1-ylmethyl)benzoic acid

Product Name
4-(4-Methylpiperazin-1-ylmethyl)benzoic acid
CAS No.
106261-48-7
Chemical Name
4-(4-Methylpiperazin-1-ylmethyl)benzoic acid
Synonyms
Imatinib-int G;Imatinib Imp.S;Imatinib Impurity S;Imatinib Impurity 42;Imatinib Impurity 36;Imatinib impurities5;4-(4-Methyl-1-piperazinylmethyl)benzoicAci;4-(4-Methyl-1-piperazinylMethyl)benzoic Acid;4-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZOIC ACID;4-(4-MethyIpiperazin-1-yImethyI)benzoic Acid
CBNumber
CB61449907
Molecular Formula
C13H18N2O2
Formula Weight
234.29
MOL File
106261-48-7.mol
More
Less

4-(4-Methylpiperazin-1-ylmethyl)benzoic acid Property

Melting point:
310-312 °C
Boiling point:
377.2±32.0 °C(Predicted)
Density 
1.174±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
4.31±0.10(Predicted)
Appearance
White to off-white Solid
Water Solubility 
Slightly soluble in water.
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

TRC
Product number
M219350
Product name
4-(4-Methylpiperazin-1-ylmethyl)benzoicAcid
Packaging
250mg
Price
$40
Updated
2021/12/16
ChemScene
Product number
CS-D0423
Product name
4-((4-Methylpiperazin-1-yl)methyl)benzoicacid
Packaging
5g
Price
$84
Updated
2021/12/16
ChemScene
Product number
CS-D0423
Product name
4-((4-Methylpiperazin-1-yl)methyl)benzoicacid
Packaging
10g
Price
$126
Updated
2021/12/16
ChemScene
Product number
CS-D0423
Product name
4-((4-Methylpiperazin-1-yl)methyl)benzoicacid
Packaging
25g
Price
$253
Updated
2021/12/16
Matrix Scientific
Product number
072050
Product name
4-(4-Methylpiperazin-1-ylmethyl)benzoic acid
Purity
95+%
Packaging
1g
Price
$347
Updated
2021/12/16
More
Less

4-(4-Methylpiperazin-1-ylmethyl)benzoic acid Chemical Properties,Usage,Production

Uses

4-(4-Methyl-1-piperazinylmethyl)benzoic acid is used as Imatinib intermediate, as pharmaceutical intermediate.

Synthesis

728936-43-4

106261-48-7

GENERAL STEPS: Methyl 4-(4-methylpiperazin-1-ylmethyl)benzoate hydrochloride (1.25 g) was dissolved in potassium hydroxide-methanol solution (0.93 g KOH dissolved in 15 ml methanol). Water (0.75 ml) was added and the mixture was heated to reflux for 1 hour. After completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted to 6 with 2 M hydrochloric acid solution. the solvent was removed by evaporation and the residue was dried under vacuum. The resulting residue contained 4-(4-methylpiperazin-1-ylmethyl)benzoic acid and the inorganic salt, which could be used in the subsequent reaction without further purification, assuming 100% yield of the title compound.1H NMR (400 MHz, d6-DMSO) δ: 2.27 (s, 3H), 2.44 (bs, 2H), 3.18-3.95 (m, 8H), 7.41 ( d, 2H, J=8Hz), 7.89 (d, 2H, J=8.1Hz).

References

[1] Patent: WO2004/63191, 2004, A1. Location in patent: Page 74

4-(4-Methylpiperazin-1-ylmethyl)benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-(4-Methylpiperazin-1-ylmethyl)benzoic acid Suppliers

Canada 1 China 159 India 16 Ukraine 1 United Kingdom 2 United States 17 Global 196
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Accela ChemBio Inc.
Tel
+1(858) 699-3322
Fax
+1(858) 876-1948
Email
marketing@accelachem.com
Country
United States
ProdList
6024
Advantage
65
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Alfa Chemistry
Tel
+1-5166625404;
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
20405
Advantage
58
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14332
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Protheragen-ING
Tel
+16313385890
Email
info@protheragen-ing.com
Country
United States
ProdList
3868
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
Aceto Corporation
Tel
--
Fax
--
Email
contact@aceto.com
Country
United States
ProdList
2619
Advantage
75
Natland International Corporation
Tel
--
Fax
--
Email
info@natland.com
Country
United States
ProdList
156
Advantage
50
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynChem，Inc
Tel
--
Fax
--
Email
sales@synchem.com
Country
United States
ProdList
4697
Advantage
58
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Sphinx Scientific Laboratory, LLC
Tel
--
Fax
--
Email
sales@sphinxscientificlab.com
Country
United States
ProdList
3343
Advantage
50
Synchem Inc.
Tel
--
Fax
--
Email
catalog@synchem.com
Country
United States
ProdList
1154
Advantage
46
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
More
Less

View Lastest Price from 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid manufacturers

Nanjing Fred Technology Co., Ltd
Product
4-(4-Methylpiperazin-1-ylmethyl)benzoic acid 106261-48-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%HPLC
Supply Ability
10tons
Release date
2023-12-06
Career Henan Chemical Co
Product
4-(4-Methylpiperazin-1-ylmethyl)benzoic acid 106261-48-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-12-20

106261-48-7, 4-(4-Methylpiperazin-1-ylmethyl)benzoic acidRelated Search:

4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride 4-(Aminomethyl)benzoic acid o-Toluic acid 4-(Chloromethyl)benzoic acid 2-(Trifluoromethyl)benzoic acid m-Toluic acid METHYL 4-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZOATE p-Toluic acid 1-Methylpiperazine 2-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZOIC ACID 95%,2-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZOIC ACID IMatinib DiPiperidine IMpurity 4-Chloromethyl-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide N-DESMETHYL IMATINIB Imatinib Impurity 7 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine Imatinib Meta-methyl-piperazine Impurity IMatinib Para-diaMinoMethylbenzene

  • 4-[(1-methyl-2-piperazinyl)methyl]benzoic acid
  • 4-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZOIC ACID
  • 4-[(4-Methyl-1-piperaziny)methyl]benzoic acid dihydrochloride
  • Benzoic acid,4-[(4-methyl-1-piperazinyl)methyl]-
  • 4-(4-Methyl-1-piperazinylMethyl)benzoic Acid
  • 4-[(4-Methyl-1-piperaziny)Methyl]benzoic acid dihy
  • Imatinib Related Compound (4-(4-Methylpiperazin-1-yl)methyl)benzoic Acid)
  • Imatinib-int G
  • Imatinib Impurity 36
  • Imatinib Impurity 42
  • Imatinib Imp.S
  • 4-(4-Methyl-1-piperazinylmethyl)benzoicacid,97%
  • 4-(4-Methyl-1-piperazinylmethyl)benzoicAci
  • 4-[(4-methylpiperazin-4-ium-1-yl)methyl]benzoate
  • Imatinib impurities5
  • 4-((4-methylpiperazin-1-yl)methyl)benzoyl acid
  • 4-(4-MethyIpiperazin-1-yImethyI)benzoic Acid
  • 4-(4-Methylpiperazin-1-ylmethyl)benzoic acid, 98%min
  • Imatinib Impurity: 4-(4-Methyl piperazinemethyl)benzoic acid dihydrochloride
  • Imatinib Impurity S
  • 106261-48-7