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tasquinimod

Product Name
tasquinimod
CAS No.
254964-60-8
Chemical Name
tasquinimod
Synonyms
TASQ);ABR-215050;tasquinimod;Tasquinimod, >98%;Tasquinimod(ABR-215050);7-diMethoxy-4-quinolinyl)oxy]-;ABR-215050; ABR215050; ABR 215050;7-Dimethoxy-quinolin-4-yloxy)-phenylamine;4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]quinoline-3-carboxamide;4-Hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-(4-(trifluoromethyl)-phenyl)-1,2-dihydroquinoline-3-c
CBNumber
CB61508619
Molecular Formula
C20H17F3N2O4
Formula Weight
406.36
MOL File
254964-60-8.mol
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tasquinimod Property

Boiling point:
501.5±50.0 °C(Predicted)
Density 
1.427±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
insoluble in H2O; ≥20.32 mg/mL in DMSO; ≥4.75 mg/mL in EtOH with gentle warming and ultrasonic
form 
solid
pka
4.50±1.00(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17692
Product name
Tasquinimod
Purity
≥98%
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
17692
Product name
Tasquinimod
Purity
≥98%
Packaging
5mg
Price
$202
Updated
2024/03/01
Cayman Chemical
Product number
17692
Product name
Tasquinimod
Purity
≥98%
Packaging
10mg
Price
$356
Updated
2024/03/01
Cayman Chemical
Product number
17692
Product name
Tasquinimod
Purity
≥98%
Packaging
25mg
Price
$593
Updated
2024/03/01
Tocris
Product number
7051
Product name
Tasquinimod
Purity
≥98%(HPLC)
Packaging
25
Price
$295
Updated
2021/12/16
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tasquinimod Chemical Properties,Usage,Production

Description

Tasquinimod is an orally-active quinoline-3-carboxamide derived from roquinimex, an immunomodulatory quinolone with applications in some cancers and autoimmune diseases. Tasquinimod inhibits tumor angiogenesis and supplements radiation or chemotherapy in animal models of prostate cancer. While its precise mechanism of action remains unclear, tasquinimod has been reported to alter signaling through S100A9, thrombospondin-1, HIF-1α, androgen receptor, VEGF, and HDAC3/4.

Uses

Tasquinimod is an orally active antiangiogenic agent which may inhibit HDAC4 signalling. This affects cancer cell survival thus making this compound and anti-cancer agent.

target

tumor microenvironment

storage

Store at -20°C

tasquinimod Preparation Products And Raw materials

Raw materials

Preparation Products

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tasquinimod Suppliers

China 93 India 2 United States 13 Global 108
Hangzhou Zyter Biological & Chemical Technology Co., Ltd.
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Hangzhou Sage Chemical Co., Ltd.
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NCE Biomedical Co.,Ltd.
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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View Lastest Price from tasquinimod manufacturers

Career Henan Chemical Co
Product
tasquinimod 254964-60-8
Price
US $1.00/KG
Min. Order
1KG
Purity
98-100%
Supply Ability
1000kg
Release date
2018-08-20

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  • 4-Hydroxy-5-methoxy-N-methyl-1-methyl-2-oxo-N-(4-trifluoromethylphenyl)-1,2-dihydroquinoline-3-carboxamide
  • N-Methyl-N-(4-trifluoromethylphenyl)-1,2-dihydro-4-hydroxy-5-methoxy-1-methyl-2-oxoquinoline-3-carboxamide
  • tasquinimod
  • ABR-215050
  • 3-QuinolinecarboxaMide, 1,2-dihydro-4-hydroxy-5-Methoxy-N,1-diMethyl-2-oxo-N-[4-(trifluoroMethyl)phenyl]-
  • 4-Hydroxy-5-Methoxy-1-Methyl-2-oxo-1,2- dihydro-quinoline-3-carboxylic acid Methyl- (4-trifluoroMethyl-phenyl)-aMide
  • 1,2-dihydro-4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-trifluoromethyl)phenyl]-3-quinolinecarboxamide
  • 4-Hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-(4-(trifluoromethyl)-phenyl)-1,2-dihydroquinoline-3-c
  • 4-Hydroxy-N-[4-(trifluoromethyl)phenyl]-5-methoxy-N,1-dimethyl-2-oxo-1,2-dihydroquinoline-3-carboxamide
  • ABR-215050; ABR215050; ABR 215050
  • Tasquinimod, >98%
  • Tasquinimod(ABR-215050)
  • TASQ)
  • 7-diMethoxy-4-quinolinyl)oxy]-
  • 7-Dimethoxy-quinolin-4-yloxy)-phenylamine
  • 4-Hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-(4-(trifluoromethyl)phenyl)-1,2-dihydroquinoline-3-carboxamide
  • 4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]quinoline-3-carboxamide
  • 254964-60-8
  • Angiogenesis inhibitor
  • S100 calcium binding protein A9 modulator
  • Inhibitors