ChemicalBook > CAS DataBase List > tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

Physical Form

Product Name: tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
CAS No.: 571188-59-5
Chemical Name: tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Synonyms: 1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE;OTAVA-BB;4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester;OTAVA-BB 1207229;1-Boc-4-(6-amino-3-pyridyl)piperazine;tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate;POB02;PALBOCICLIB4;Ribociclib-2;Palbociclib-11
CBNumber: CB62464781
Molecular Formula: C14H22N4O2
Formula Weight: 278.35
MOL File: 571188-59-5.mol

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tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Property

Melting point:: 130-132℃
Boiling point:: 454.1±45.0 °C(Predicted)
Density: 1.182
vapor pressure: 0-0Pa at 20-25℃
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Very Slightly)
form: Solid
pka: 7.36±0.26(Predicted)
color: Dark Yellow
Sensitive: Air Sensitive
InChI: InChI=1S/C14H22N4O2/c1-14(2,3)20-13(19)18-8-6-17(7-9-18)11-4-5-12(15)16-10-11/h4-5,10H,6-9H2,1-3H3,(H2,15,16)
InChIKey: RMULRXHUNOVPEI-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(N)N=C2)CC1
LogP: 1.6-1.8 at 35℃ and pH7-9

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4669
Product name: tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate
Purity: >98.0%(HPLC)(T)
Packaging: 200mg
Price: $68
Updated: 2025/07/31

TCI Chemical

Product number: B4669
Product name: tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $239
Updated: 2024/03/01

TRC

Product number: B621160
Product name: 1-Boc-4-(6-aminopyridin-3-yl)piperazine
Packaging: 100mg
Price: $55
Updated: 2021/12/16

TRC

Product number: B621160
Product name: 1-Boc-4-(6-aminopyridin-3-yl)piperazine
Packaging: 250mg
Price: $110
Updated: 2021/12/16

TRC

Product number: B621160
Product name: 1-Boc-4-(6-aminopyridin-3-yl)piperazine
Packaging: 5g
Price: $450
Updated: 2021/12/16

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tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Chemical Properties,Usage,Production

Physical Form

Solid

Description

Tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is a pharmaceutical intermediate compound that can be used to synthesize the targeted cancer drug Ribociclib for the treatment of ER-positive and HER2-negative breast cancer.

Uses

4-(6-Amino-3-pyridyl)-1-Boc-piperazine (tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate) is used as an organic chemical synthesis intermediate.

Preparation

4- (6-Nitro-pyridin-3-yl)-piperazine-1 -carboxylic acid ie f-butyl ester and Pd/C in ethanol is stirred with an H2 balloon for 3 h. The product tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is obtained through purification.

Hazard

Causes skin irritation
Causes serious eye irritation
May cause respiratory irritation

Synthesis

571189-16-7

571188-59-5

General Steps: Example 101h Synthesis of tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 101h To a 500 mL triple-necked vial under nitrogen protection was added tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate 101g (3.1 g, 10 mmol), 10% palladium-carbon catalyst (50% wet, 1.0 g) and anhydrous ethanol (100 mL). The reaction system was evacuated and filled with hydrogen, and the reaction was stirred at room temperature for 16 hours. Upon completion of the reaction, the hydrogen was removed by evacuation and refilled with nitrogen for protection. The reaction mixture was filtered through a diatomaceous earth pad to remove the catalyst and the filtrate was concentrated under reduced pressure to give the target compound 101h (2.7 g, 97% yield). Mass spectral data: MS: [M + H]+ 279.

References

[1] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 6, p. 3125 - 3140
[2] Patent: WO2016/30439, 2016, A1. Location in patent: Page/Page column 30
[3] Patent: WO2011/140488, 2011, A1. Location in patent: Page/Page column 112; 270
[4] Patent: US2013/116262, 2013, A1. Location in patent: Paragraph 0315
[5] Patent: EP2773638, 2015, B1. Location in patent: Paragraph 0170; 0171; 1405

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 571188-59-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-28

Sinoway Industrial co., ltd.

Product: Palbociclib side chain 571188-59-5
Price: US $0.00-0.00/Kg/Bag
Min. Order: 2Kg/Bag
Purity: 0.98
Supply Ability: 20 tons
Release date: 2023-05-23

Henan Aochuang Chemical Co.,Ltd.

Product: tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 571188-59-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

571188-59-5, tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylateRelated Search:

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one 1-N-BOC-4-BROMOPIPERIDINE Copper(II) chloride dihydrate Iodomethane sacubitril 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)- 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER PD 0332991 HCl 1-Piperazinecarboxylic acid, 4-[6-[[7-cyclopentyl-6-[(diMethylaMino)carbonyl]-7H-pyrrolo[2,3-d]pyriMidin-2-yl]aMino]-3-pyridinyl]-, 1,1-diMethylethyl ester LEE011 (succinate) 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide 5-(2-Fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-2,4(1H,3H)-pyrimidinedione 1,4-BenzenediaMine, N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]-2-nitro- LEE011 (hydrochloride) 1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)- Palbociclib tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate

1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE

OTAVA-BB 1207229

4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester

1-Piperazinecarboxylic acid, 4-(6-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester

tert-butyl 4-(6-aMinopyri

4-(6-aMinopyridin-3-yl)piperazine-1-carboxylic

PALBOCICLIB4

2-Methyl-2-propanyl 4-(6-amino-3-pyridinyl)-1-piperazinecarboxylate

6-(6-Aminopyridin-3-yl)piperazine, N1-BOC protected 98%

1-Butyloxycarbonyl-4-(6-aminopyridin-3-yl)-piperazine

Palbociclib Impurity 68

Palbociclib-018

Palbociclib-11

Tert-buty 4-(6-amino-3-pyridyl)piperazine-1-carboxylate

POB02

OTAVA-BB 1207229/1-Boc-4-(6-aminopyridin-3-yl)piperazine

tert-butyl 4-(6-aminoyridin-3-yl)pipera-zine-1-carboxylate

4-(6-AMinopyridin-3-yl)-1-Boc-piperazine

tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate

tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate(For Palbociclib)

Palbociclib's intermediate

4-(6-aMinopyridin-3-yl)p

t-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)- (acetate)

Palbociclib Intermediate

Ribociclib-2

<i>tert</i>-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate

Tert-Butyl 4-(6-Amino-3-Pyrimidin)Piperazine-1-Carboxylate

4-(6-Amino-3-pyridyl)piperazine-1-carboxylic Acid tert-Butyl Ester

OTAVA-BB 1207229 tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

1-(tert-Butoxycarbonyl)-4-(6-aminopyridin-3-yl)piperazine

OTAVA-BB

Palbociclib Intermediate 1, tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

OTAVA-BB 1207229/1-Boc-4-(6-aminopyridin-3-yl)piperazine(571188-59-5)

4-(6-Amino-3-pyridyl)-1-Boc-piperazine

1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZIN

tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate &gt

4-(6-aminopyridine-3-yl) piperazine-1-carboxylic tert-butyl ester

)piperazine-1-carboxyL

Ribociclib Related Compound 1

Tert-Butyl 4-(6-aminopyridin-3-piperazine-1-carboxylate

4-(6- aminopyridine -3- yl) piperazine -1- tert-butyl carboxylate

ert-Butyl4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

1-Boc-4-(6-amino-3-pyridyl)piperazine

1-tert-Butoxycarbonyl-4-(6-amino-3-pyridyl)piperazine

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

Palbociclib side chain

4- (6-aminopyridine-3-yl) piperazin-1-carboxylic acid tert-butyl ester

tert-Butyl-4-(6-aminopyridin-3-yl)piperazin-1-carboxylate

4-(6-AMinopyridin-3-yl)-1-Boc-piperazin

6-(6-Aminopyridin-3-yl)piperazine, N1-BOC protected

571188-59-5

571188-59-9

PD 0332991

Palbociclib

Anticancer

571188-59-5