Physical Form
ChemicalBook > CAS DataBase List > tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

Physical Form
Product Name
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
CAS No.
571188-59-5
Chemical Name
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Synonyms
1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE;OTAVA-BB;4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester;OTAVA-BB 1207229;1-Boc-4-(6-amino-3-pyridyl)piperazine;tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate;POB02;PALBOCICLIB4;Ribociclib-2;Palbociclib-11
CBNumber
CB62464781
Molecular Formula
C14H22N4O2
Formula Weight
278.35
MOL File
571188-59-5.mol
More
Less

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Property

Melting point:
130-132℃
Boiling point:
454.1±45.0 °C(Predicted)
Density 
1.182
vapor pressure 
0-0Pa at 20-25℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Very Slightly)
form 
Solid
pka
7.36±0.26(Predicted)
color 
Dark Yellow
Sensitive 
Air Sensitive
InChI
InChI=1S/C14H22N4O2/c1-14(2,3)20-13(19)18-8-6-17(7-9-18)11-4-5-12(15)16-10-11/h4-5,10H,6-9H2,1-3H3,(H2,15,16)
InChIKey
RMULRXHUNOVPEI-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(N)N=C2)CC1
LogP
1.6-1.8 at 35℃ and pH7-9
More
Less

Safety

HS Code 
2933599590
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
B4669
Product name
tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate
Purity
>98.0%(HPLC)(T)
Packaging
200mg
Price
$66
Updated
2024/03/01
TCI Chemical
Product number
B4669
Product name
tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$239
Updated
2024/03/01
Alfa Aesar
Product number
H54315
Product name
4-(6-Amino-3-pyridyl)-1-Boc-piperazine, 97%
Packaging
1g
Price
$170.65
Updated
2024/03/01
Alfa Aesar
Product number
H54315
Product name
4-(6-Amino-3-pyridyl)-1-Boc-piperazine, 97%
Packaging
5g
Price
$673.65
Updated
2024/03/01
Alfa Aesar
Product number
H54315
Product name
4-(6-Amino-3-pyridyl)-1-Boc-piperazine, 97%
Packaging
250mg
Price
$57.6
Updated
2021/12/16
More
Less

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Chemical Properties,Usage,Production

Physical Form

Solid

Description

Tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is a pharmaceutical intermediate compound that can be used to synthesize the targeted cancer drug Ribociclib for the treatment of ER-positive and HER2-negative breast cancer.

Uses

4-(6-Amino-3-pyridyl)-1-Boc-piperazine (tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate) is used as an organic chemical synthesis intermediate.

Preparation

4- (6-Nitro-pyridin-3-yl)-piperazine-1 -carboxylic acid ie f-butyl ester and Pd/C in ethanol is stirred with an H2 balloon for 3 h. The product tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is obtained through purification.

Hazard

Causes skin irritation
Causes serious eye irritation
May cause respiratory irritation

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Suppliers

Americas 1 China 493 Europe 1 France 1 Germany 3 India 46 Japan 1 Switzerland 1 United Kingdom 4 United States 25 Global 576
BTC pharm India
Tel
+918790379245
Email
banny.janga@btcpharm.com
Country
India
ProdList
1262
Advantage
58
TCI Chemicals (India) Pvt. Ltd.
Tel
--
Fax
--
Email
sales-in@tcichemicals.com
Country
India
ProdList
6768
Advantage
58
VASUDHA PHARMA CHEM LIMITED
Tel
--
Fax
--
Email
vasudha@vasudhapharma.com
Country
India
ProdList
76
Advantage
58
Shree Jaya Laboratories Pvt. Ltd.
Tel
--
Fax
--
Email
info@shreejayalaboratories.com
Country
India
ProdList
11
Advantage
58
Manus Aktteva Biopharma LLP
Tel
--
Fax
--
Email
products@manusakttevabiopharma.in
Country
India
ProdList
275
Advantage
58
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
India
ProdList
6905
Advantage
58
AARTI INDUSTRIES LIMITED
Tel
--
Fax
--
Email
info@aarti-industries.com
Country
India
ProdList
172
Advantage
58
Anant Pharmaceuticals Pvt. ltd
Tel
--
Fax
--
Email
info@anantlabs.com
Country
India
ProdList
736
Advantage
58
P. D. Polychem Pvt., Ltd.
Tel
--
Fax
--
Email
info@pdpolychem.com
Country
India
ProdList
19
Advantage
58
Santo Righello Pvt. Ltd
Tel
--
Fax
--
Email
marketing@santorighello.com
Country
India
ProdList
918
Advantage
58
VASIN BIO LIFE SCIENCES PVT LTD
Tel
--
Fax
--
Email
info@vasinbio.com
Country
India
ProdList
2092
Advantage
58
Parth Antibiotics Pvt., Ltd.
Tel
--
Fax
--
Email
info@parthantibiotics.com
Country
India
ProdList
137
Advantage
58
Rivashaa Agrotech Biopharma Pvt. Ltd.
Tel
--
Fax
--
Email
source@rivashaa.com
Country
India
ProdList
986
Advantage
58
Pharma Affiliates
Tel
--
Fax
--
Email
@pharmaffiliates.com
Country
India
ProdList
6754
Advantage
58
Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group)
Tel
--
Fax
--
Email
mayur@archerchem.com
Country
India
ProdList
147
Advantage
58
Ethachem
Tel
--
Fax
--
Email
ethachem@vsnl.com
Country
India
ProdList
106
Advantage
58
Ami Organics Limited.
Tel
--
Fax
--
Email
mail@amiorganics.com
Country
India
ProdList
119
Advantage
58
Eastern Chemicals (Mumbai) Pvt., Ltd.
Tel
--
Fax
--
Email
info@ecmpl.com
Country
India
ProdList
104
Advantage
58
Hrishabh Life Sciences
Tel
--
Fax
--
Email
info@hrishabhlife.com
Country
India
ProdList
158
Advantage
58
ALTAIR ALCHEMY Laboratories
Tel
--
Fax
--
Email
altair@altair-alchemy.com
Country
India
ProdList
324
Advantage
58
Opulent Pharma
Tel
--
Fax
--
Country
India
ProdList
810
Advantage
58
SynZeal Research Pvt Ltd
Tel
--
Fax
--
Email
standards@synzeal.com
Country
India
ProdList
6514
Advantage
58
Amara Labs Private Limited
Tel
--
Fax
--
Email
Dharani@amaralabs.in
Country
India
ProdList
34
Advantage
58
Reax Chemicals
Tel
--
Fax
--
Country
India
ProdList
4217
Advantage
58
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
--
Fax
--
Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
More
Less

View Lastest Price from tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate manufacturers

Sinoway Industrial co., ltd.
Product
Palbociclib side chain 571188-59-5
Price
US $0.00-0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
0.98
Supply Ability
20 tons
Release date
2023-05-23
Nanjing Fred Technology Co., Ltd
Product
Tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 571188-59-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-28
WUHAN FORTUNA CHEMICAL CO., LTD
Product
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 571188-59-5
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-30

571188-59-5, tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylateRelated Search:

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one 1-N-BOC-4-BROMOPIPERIDINE Copper(II) chloride dihydrate Iodomethane sacubitril 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)- 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER PD 0332991 HCl 1-Piperazinecarboxylic acid, 4-[6-[[7-cyclopentyl-6-[(diMethylaMino)carbonyl]-7H-pyrrolo[2,3-d]pyriMidin-2-yl]aMino]-3-pyridinyl]-, 1,1-diMethylethyl ester LEE011 (succinate) 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide 5-(2-Fluoro-3-methoxyphenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-6-methyl-2,4(1H,3H)-pyrimidinedione 1,4-BenzenediaMine, N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]-2-nitro- LEE011 (hydrochloride) 1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)- Palbociclib tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate

  • 1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE
  • OTAVA-BB 1207229
  • 4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester
  • 1-Piperazinecarboxylic acid, 4-(6-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester
  • tert-butyl 4-(6-aMinopyri
  • 4-(6-aMinopyridin-3-yl)piperazine-1-carboxylic
  • PALBOCICLIB4
  • 2-Methyl-2-propanyl 4-(6-amino-3-pyridinyl)-1-piperazinecarboxylate
  • 6-(6-Aminopyridin-3-yl)piperazine, N1-BOC protected 98%
  • 1-Butyloxycarbonyl-4-(6-aminopyridin-3-yl)-piperazine
  • Palbociclib Impurity 68
  • Palbociclib-018
  • Palbociclib-11
  • Tert-buty 4-(6-amino-3-pyridyl)piperazine-1-carboxylate
  • POB02
  • OTAVA-BB 1207229/1-Boc-4-(6-aminopyridin-3-yl)piperazine
  • tert-butyl 4-(6-aminoyridin-3-yl)pipera-zine-1-carboxylate
  • 4-(6-AMinopyridin-3-yl)-1-Boc-piperazine
  • tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate
  • tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate(For Palbociclib)
  • Palbociclib's intermediate
  • 4-(6-aMinopyridin-3-yl)p
  • t-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
  • 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)- (acetate)
  • Palbociclib Intermediate
  • Ribociclib-2
  • <i>tert</i>-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate
  • Tert-Butyl 4-(6-Amino-3-Pyrimidin)Piperazine-1-Carboxylate
  • 4-(6-Amino-3-pyridyl)piperazine-1-carboxylic Acid tert-Butyl Ester
  • OTAVA-BB 1207229 tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
  • 1-(tert-Butoxycarbonyl)-4-(6-aminopyridin-3-yl)piperazine
  • OTAVA-BB
  • Palbociclib Intermediate 1, tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
  • OTAVA-BB 1207229/1-Boc-4-(6-aminopyridin-3-yl)piperazine(571188-59-5)
  • 4-(6-Amino-3-pyridyl)-1-Boc-piperazine
  • 1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZIN
  • tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate &gt
  • 4-(6-aminopyridine-3-yl) piperazine-1-carboxylic tert-butyl ester
  • )piperazine-1-carboxyL
  • Ribociclib Related Compound 1
  • Tert-Butyl 4-(6-aminopyridin-3-piperazine-1-carboxylate
  • 4-(6- aminopyridine -3- yl) piperazine -1- tert-butyl carboxylate
  • ert-Butyl4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
  • 1-Boc-4-(6-amino-3-pyridyl)piperazine
  • 1-tert-Butoxycarbonyl-4-(6-amino-3-pyridyl)piperazine
  • tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
  • 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
  • Palbociclib side chain
  • 4- (6-aminopyridine-3-yl) piperazin-1-carboxylic acid tert-butyl ester
  • tert-Butyl-4-(6-aminopyridin-3-yl)piperazin-1-carboxylate
  • 571188-59-5
  • 571188-59-9
  • PD 0332991
  • Palbociclib
  • Anticancer
  • 571188-59-5