ChemicalBook > CAS DataBase List > tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Physical Form- Product Name
- tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
- CAS No.
- 571188-59-5
- Chemical Name
- tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
- Synonyms
- 1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE;OTAVA-BB;4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester;OTAVA-BB 1207229;1-Boc-4-(6-amino-3-pyridyl)piperazine;tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate;POB02;PALBOCICLIB4;Ribociclib-2;Palbociclib-11
- CBNumber
- CB62464781
- Molecular Formula
- C14H22N4O2
- Formula Weight
- 278.35
- MOL File
- 571188-59-5.mol
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tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Property
- Melting point:
- 130-132℃
- Boiling point:
- 454.1±45.0 °C(Predicted)
- Density
- 1.182
- vapor pressure
- 0-0Pa at 20-25℃
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Very Slightly)
- form
- Solid
- pka
- 7.36±0.26(Predicted)
- color
- Dark Yellow
- Sensitive
- Air Sensitive
- InChI
- InChI=1S/C14H22N4O2/c1-14(2,3)20-13(19)18-8-6-17(7-9-18)11-4-5-12(15)16-10-11/h4-5,10H,6-9H2,1-3H3,(H2,15,16)
- InChIKey
- RMULRXHUNOVPEI-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(N)N=C2)CC1
- LogP
- 1.6-1.8 at 35℃ and pH7-9
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Safety
- HS Code
- 2933599590
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- B4669
- Product name
- tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 200mg
- Price
- $66
- Updated
- 2024/03/01
TCI Chemical
- Product number
- B4669
- Product name
- tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $239
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- H54315
- Product name
- 4-(6-Amino-3-pyridyl)-1-Boc-piperazine, 97%
- Packaging
- 1g
- Price
- $170.65
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- H54315
- Product name
- 4-(6-Amino-3-pyridyl)-1-Boc-piperazine, 97%
- Packaging
- 5g
- Price
- $673.65
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- H54315
- Product name
- 4-(6-Amino-3-pyridyl)-1-Boc-piperazine, 97%
- Packaging
- 250mg
- Price
- $57.6
- Updated
- 2021/12/16
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tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Chemical Properties,Usage,Production
Physical Form
Solid
Description
Tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is a pharmaceutical intermediate compound that can be used to synthesize the targeted cancer drug Ribociclib for the treatment of ER-positive and HER2-negative breast cancer.
Uses
4-(6-Amino-3-pyridyl)-1-Boc-piperazine (tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate) is used as an organic chemical synthesis intermediate.
Preparation
4- (6-Nitro-pyridin-3-yl)-piperazine-1 -carboxylic acid ie f-butyl ester and Pd/C in ethanol is stirred with an H2 balloon for 3 h. The product tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is obtained through purification.
Hazard
Causes skin irritation
Causes serious eye irritation
May cause respiratory irritation
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
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View Lastest Price from tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate manufacturers
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 571188-59-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-30
Sinoway Industrial co., ltd.
- Product
- Palbociclib side chain 571188-59-5
- Price
- US $0.00-0.00/Kg/Bag
- Min. Order
- 2Kg/Bag
- Purity
- 0.98
- Supply Ability
- 20 tons
- Release date
- 2023-05-23
Nanjing Fred Technology Co., Ltd
- Product
- Tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 571188-59-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-28
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