ChemicalBook > CAS DataBase List > NVP-BSK805

NVP-BSK805

Product Name: NVP-BSK805
CAS No.: 1092499-93-8
Chemical Name: NVP-BSK805
Synonyms: BSK805;CS-550;CS-1571;BSK 805;BSK-805;NVP-BSK805;NVP-GSK 805;NVP-BSK805 2HCl;NVP-BSK805 - BSK 805;NVP-BSK805 USP/EP/BP
CBNumber: CB62561486
Molecular Formula: C27H28F2N6O
Formula Weight: 490.55
MOL File: 1092499-93-8.mol

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NVP-BSK805 Property

Melting point:: 137℃
Boiling point:: 639.8±55.0 °C(Predicted)
Density: 1.4
storage temp.: Store at -20°C
solubility: ≥20.95 mg/mL in DMSO; ≥3.45 mg/mL in H2O with gentle warming and ultrasonic; ≥4.75 mg/mL in EtOH with gentle warming and ultrasonic
form: solid
pka: 9.78±0.10(Predicted)
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 5818
Product name: NVPBSK805
Purity: ≥98%(HPLC)
Packaging: 10
Price: $205
Updated: 2021/12/16

Axon Medchem

Product number: Axon2792
Product name: NVP-BSK805-BSK805
Purity: 99%
Packaging: 5mg
Price: $137.5
Updated: 2021/12/16

ApexBio Technology

Product number: A3675
Product name: NVP-BSK805
Packaging: 5mg
Price: $179
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD43354
Product name: NVP BSK 805
Packaging: 10mg
Price: $185
Updated: 2021/12/16

AK Scientific

Product number: 2606AH
Product name: NVP-BSK805dihydrochloride
Packaging: 2mg
Price: $200
Updated: 2021/12/16

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NVP-BSK805 Chemical Properties,Usage,Production

Uses

NVP-BSK805 is an ATP-competitive JAK2 inhibitor, with IC50s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively[1].

in vivo

NVP-BSK805 (BSK 805; 150 mg/kg, p.o.) blocks STAT5 phosphorylation, splenomegaly, and leukemic cell spreading in a Ba/F3 JAK2^V617F cell-driven mouse model^[1].
NVP-BSK805 (50, 75, and 100 mg/kg, p.o.) also suppresses rhEpo-mediated polycythemia and splenomegaly in BALB/c mice^[1].

target

JAK2

IC 50

JAK2 JH1: 0.48 nM (IC₅₀); FL JAK2 V617F: 0.56 nM (IC₅₀); FL JAK2 wt: 0.58 nM (IC₅₀); TYK2 JH1: 10.76 nM (IC₅₀); JAK3 JH1: 18.68 nM (IC₅₀); JAK1 JH1: 31.63 nM (IC₅₀)

References

[1] Baffert F, et al. Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Mol Cancer Ther. 2010 Jul;9(7):1945-55. DOI:10.1158/1535-7163.MCT-10-0053
[2] Cheon JH, et al. The JAK2 inhibitors CEP-33779 and NVP-BSK805 have high P-gp inhibitory activity and sensitize drug-resistant cancer cells to vincristine. Biochem Biophys Res Commun. 2017 Sep 2;490(4):1176-1182. DOI:10.1016/j.bbrc.2017.06.178

NVP-BSK805 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from NVP-BSK805 manufacturers

Career Henan Chemical Co

Product: NVP-BSK805 1092499-93-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-30

1092499-93-8, NVP-BSK805Related Search:

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NVP-BSK805 2HCl

NVP-BSK805

NVP-BSK805 dihydrochloride

8-[3,5-Difluoro-4-(4-morpholinylmethyl)phenyl]-2-[1-(4-piperidinyl)-1H-pyrazol-4-yl]quinoxaline

8-(3,5-difluoro-4-(morpholinomethyl)phenyl)-2-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxaline

BSK 805

BSK805

BSK-805

4-(2,6-Difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxalin-5-yl)benzyl)morpholine

NVP-BSK805 - BSK 805

CS-1571

BSK 805; BSK-805; BSK805; NVP-BSK 805

CS-550

NVP-GSK 805

Quinoxaline, 8-[3,5-difluoro-4-(4-morpholinylmethyl)phenyl]-2-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-

NVP-BSK805 USP/EP/BP

NVP-BSK805(freebase)

8-{3,5-difluoro-4-[(morpholin-4-yl)methyl]phenyl}-2-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]quinoxaline

NVP-BSK805 dihydrochloride (BSK805 dihydrochloride

1092499-93-8

C27H28F2N6O

C27H28F2N6O2HCl

Inhibitors

JAK

STAT

Inhibitor