2,5-Difluoroaniline

Product Name: 2,5-Difluoroaniline
CAS No.: 367-30-6
Chemical Name: 2,5-Difluoroaniline
Synonyms: 2,5-DIFLUOROBENZENAMINE;Difluoroaniline3;2,5-Difluoranilin;2,5-DIFLUOROANILINE;Aniline, 2,5-difluoro-;2,5-Difluoroaniline,98%;2,5-Difluoroaniline 98%;2,5-Difluoroaniline,99%;2,5-Difluoroaniline >2,5-Difluoro-phenylamine
CBNumber: CB6299323
Molecular Formula: C6H5F2N
Formula Weight: 129.11
MOL File: 367-30-6.mol

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2,5-Difluoroaniline Property

Melting point:: 11-13 °C (lit.)
Boiling point:: 176-178 °C (lit.)
Density: 1.288 g/mL at 25 °C (lit.)
refractive index: n20/D 1.513(lit.)
Flash point:: 156 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 2.19±0.10(Predicted)
form: clear liquid
color: Colorless to Yellow to Orange
Specific Gravity: 1.29
Water Solubility: Not miscible in water.
BRN: 2802549
InChI: InChI=1S/C6H5F2N/c7-4-1-2-5(8)6(9)3-4/h1-3H,9H2
InChIKey: YNOOQIUSYGWMSS-UHFFFAOYSA-N
SMILES: C1(N)=CC(F)=CC=C1F
CAS DataBase Reference: 367-30-6(CAS DataBase Reference)
NIST Chemistry Reference: Benzenamine, 2,5-difluoro-(367-30-6)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 28-36/37/39-26-36
RIDADR: 2941
WGK Germany: 3
F: 8-10-23
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29214210

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 196606
Product name: 2,5-Difluoroaniline
Purity: 99.5%
Packaging: 25g
Price: $33.15
Updated: 2025/07/31

Sigma-Aldrich

Product number: 196606
Product name: 2,5-Difluoroaniline
Purity: 99.5%
Packaging: 5g
Price: $27
Updated: 2023/06/20

TCI Chemical

Product number: D1634
Product name: 2,5-Difluoroaniline
Purity: >98.0%(GC)
Packaging: 5g
Price: $37
Updated: 2025/07/31

TCI Chemical

Product number: D1634
Product name: 2,5-Difluoroaniline
Purity: >98.0%(GC)
Packaging: 25g
Price: $118
Updated: 2025/07/31

TRC

Product number: D442320
Product name: 2,5-Difluoroaniline
Packaging: 1g
Price: $55
Updated: 2021/12/16

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2,5-Difluoroaniline Chemical Properties,Usage,Production

Chemical Properties

clear brown liquid

Uses

2,5-Difluoroaniline was used in the synthesis of 2,4-di-tert-butyl-6-[(2,5-difluorophenyl)iminomethyl]phenol. It was also used in ultrasound-assisted preparation of 1,4-diazabutadienes. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuff.

Synthesis

364-74-9

367-30-6

General procedure for the synthesis of 2,5-difluoroaniline from 2,5-difluoronitrobenzene: To a solution of 1,4-difluoro-2-nitrobenzene (500 mg, 3.14 mmol) in methanol (20 mL) was added palladium/carbon catalyst (66.9 mg, 0.629 mmol) in batches. Subsequently, the reaction mixture was stirred at 20 °C for 1 h under hydrogen atmosphere. The reaction progress was monitored by thin layer chromatography (TLC, petroleum ether/ethyl acetate = 3/1) and after confirming the complete consumption of raw materials, the reaction mixture was filtered. The filtrate was concentrated to afford the target product 2,5-difluoroaniline (338 mg, 2.61 mmol, 83% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 6.94-6.88 (m, 1H), 6.50-6.46 (m, 1H), 6.40-6.31 (m, 1H), 3.82 (br.s., 2H).

References

[1] Patent: US2014/275111, 2014, A1. Location in patent: Paragraph 0485; 0486
[2] Patent: WO2014/141187, 2014, A1. Location in patent: Page/Page column 109
[3] Recueil des Travaux Chimiques des Pays-Bas, 1914, vol. 33, p. 299
[4] Chem. Zentralbl., 1914, vol. 85, # II, p. 320
[5] Journal fuer Praktische Chemie (Leipzig), 1934, vol. <2> 140, p. 97,111

2,5-Difluoroaniline Preparation Products And Raw materials

Raw materials

1,4-Difluorobenzene Nitric acid Iron

Preparation Products

4-BROMO-2,5-DIFLUOROBENZENESULFONYL CHLORIDE

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2,5-Difluoroaniline Suppliers

Americas 1 Belgium 1 China 244 Europe 4 France 1 Germany 4 India 10 Italy 1 Japan 5 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 2 United Kingdom 21 United States 48 Global 347

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View Lastest Price from 2,5-Difluoroaniline manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2,5-Difluoroaniline 367-30-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20t
Release date: 2024-06-18

Henan Fengda Chemical Co., Ltd

Product: 2,5-Difluoroaniline 367-30-6
Price: US $50.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-22

Honest Joy Holdings Limited

Product: 2,5-Difluoroaniline 367-30-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.3%
Supply Ability: 100 tons
Release date: 2022-02-18

367-30-6, 2,5-DifluoroanilineRelated Search:

N,N-Dimethylaniline Diphenylamine 3-Fluoroaniline 4-(Trifluoromethoxy)aniline N,N-Dimethyl-1,4-phenylenediamine 2-Fluoroaniline Sodium diphenylamine-4-sulfonate 2-Aminobenzotrifluoride 4-Fluoroaniline PENTAFLUORONITROBENZENE 1,2,4-Trifluoro-5-nitrobenzene PENTAFLUOROPHENYLHYDRAZINE 3,4-Difluoroaniline 2,3,5,6-TETRAFLUOROPHENYLHYDRAZINE 4-AMINO-2,3,5,6-TETRAFLUOROBENZAMIDE 3,5-Difluoroaniline 2,3-DIFLUOROANILINE 2,4-Difluoroaniline

Aniline, 2,5-difluoro-

2,5-DIFLUOROANILINE

2,5-DIFLUOROBENZENAMINE

2,5-Difluoroaniline 98%

2,5-Difluoroaniline,98%

Difluoroaniline3

2,5-DIFLUOROANILINE, 99.5%

Benzenamine, 2,5-difluoro-

2,5-Difluoroaniline,99%

2,5-Difluoro-phenylamine

2,5-Difluoroaniline, 99% 25ML

2,5-Difluoroaniline, 2,5-DifluorobenzenaMine

Aniline, 2,5-difluoro- (6CI,7CI,8CI)

2,5-Difluoroaniline &gt

2,5-Difluoranilin

2,5-Difluoroaniline ISO 9001：2015 REACH

367-30-6

Amines

Building Blocks

C2 to C6

Organic Building Blocks

Nitrogen Compounds

Anilines, Aromatic Amines and Nitro Compounds

Aniline

Fluorobenzene

Miscellaneous

Amines

C2 to C6

Nitrogen Compounds

bc0001