Z-DEVD-FMK
- Product Name
- Z-DEVD-FMK
- CAS No.
- 210344-95-9
- Chemical Name
- Z-DEVD-FMK
- Synonyms
- S7312;CS-1505;CTK8E8674;abs812077;Z-DEVD-FMK;AG-B-56189;CASPASE-3, INHIBITOR;CASPASE-3 INHIBITOR2;Z-DEVD-FMK USP/EP/BP;CASPASE-3 INHIBITOR II
- CBNumber
- CB6453635
- Molecular Formula
- C30H41FN4O12
- Formula Weight
- 668.66
- MOL File
- Mol file
Z-DEVD-FMK Property
- Boiling point:
- 914.2±65.0 °C(Predicted)
- Density
- 1.260±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO/DMF: ≥20 mM
- form
- White to slightly brown solid
- pka
- 10.26±0.46(Predicted)
- color
- White to off-white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 264155
- Product name
- Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem
- Purity
- The Caspase-3 Inhibitor II, also referenced under CAS 210344-95-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.
- Packaging
- 250μG
- Price
- $144
- Updated
- 2024/03/01
- Product number
- 264155
- Product name
- Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem
- Packaging
- 1mg
- Price
- $417
- Updated
- 2024/03/01
- Product number
- 14414
- Product name
- Z-DEVD-FMK
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $111
- Updated
- 2024/03/01
- Product number
- 14414
- Product name
- Z-DEVD-FMK
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $210
- Updated
- 2024/03/01
- Product number
- 14414
- Product name
- Z-DEVD-FMK
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $820
- Updated
- 2024/03/01
Z-DEVD-FMK Chemical Properties,Usage,Production
Uses
Z-DEVD-FMK is an irrversible caspase-3 inhibitor used as an anaesthetic agent. In addition, it is proposed to increase the longevity of platelet storage.
Definition
ChEBI: Z-DEVD-FMK is a tetrapeptide consisting of Fmoc-L-aspartic acid 4-methyl ester, methyl L-alpha-glutamic acid 5-methyl ester, L-valine and the fluoromethyl ketone derived from the 1-carboxy group of L-aspartic acid 4-methyl ester coupled in sequence. It is a specific, irreversible caspase-3 inhibitor that also shows potent inhibition of caspase-6, caspase-7, caspase-8, and caspase-10. It has a role as an apoptosis inhibitor, an EC 3.4.22.56 (caspase-3) inhibitor and a neuroprotective agent.
General Description
A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 μg/75 μl) solution of Z-DEVD-FMK (Cat. No. 264156) in DMSO is also available.
Biological Activity
Cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumor cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo .
Biochem/physiol Actions
Cell permeable: yes
target
Caspase-3
References
1. garcia-calvo m, peterson ep, leiting b, ruel r, nicholson dw, thornberry na (1998) inhibition of human caspases by peptidebased and macromolecular inhibitors. j biol chem 273:32608–32613 2. thornberry na, rano ta, peterson ep, rasper dm, timkey t, garcia-calvo m, houtzager vm, nordstrom pa, roy s, vaillancourt jp, chapman kt, nicholson dw (1997) a combinatorial approach defines specificities of members of the caspase family and granzyme b. functional relationships established for key mediators of apoptosis. j biol chem 272:17907–17911 3. yakovlev ag, knoblach sm, fan l, fox gb, goodnight r, faden ai (1997) activation of cpp32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. j neurosci 17:7415–7424 4. clark rs, kochanek pm, watkins sc, chen m, dixon ce, seidberg na, melick j, loeffert je, nathaniel pd, jin kl, graham sh (2000) caspase-3 mediated neuronal death after traumatic brain injury in rats. j neurochem 74:740–753 5. s. m. knoblach, d. a. alroy et al, caspase inhibitor z-devd-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury, journal of cerebral blood flow & metabolism 24:1119–1132.
Z-DEVD-FMK Preparation Products And Raw materials
Raw materials
Preparation Products
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