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Z-DEVD-FMK

Product Name
Z-DEVD-FMK
CAS No.
210344-95-9
Chemical Name
Z-DEVD-FMK
Synonyms
S7312;CS-1505;CTK8E8674;abs812077;Z-DEVD-FMK;AG-B-56189;CASPASE-3, INHIBITOR;CASPASE-3 INHIBITOR2;Z-DEVD-FMK USP/EP/BP;CASPASE-3 INHIBITOR II
CBNumber
CB6453635
Molecular Formula
C30H41FN4O12
Formula Weight
668.66
MOL File
Mol file
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Z-DEVD-FMK Property

Boiling point:
914.2±65.0 °C(Predicted)
Density 
1.260±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO/DMF: ≥20 mM
form 
White to slightly brown solid
pka
10.26±0.46(Predicted)
color 
White to off-white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
264155
Product name
Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem
Purity
The Caspase-3 Inhibitor II, also referenced under CAS 210344-95-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.
Packaging
250μG
Price
$144
Updated
2024/03/01
Sigma-Aldrich
Product number
264155
Product name
Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem
Packaging
1mg
Price
$417
Updated
2024/03/01
Cayman Chemical
Product number
14414
Product name
Z-DEVD-FMK
Purity
≥95%
Packaging
500μg
Price
$111
Updated
2024/03/01
Cayman Chemical
Product number
14414
Product name
Z-DEVD-FMK
Purity
≥95%
Packaging
1mg
Price
$210
Updated
2024/03/01
Cayman Chemical
Product number
14414
Product name
Z-DEVD-FMK
Purity
≥95%
Packaging
5mg
Price
$820
Updated
2024/03/01
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Z-DEVD-FMK Chemical Properties,Usage,Production

Uses

Z-DEVD-FMK is an irrversible caspase-3 inhibitor used as an anaesthetic agent. In addition, it is proposed to increase the longevity of platelet storage.

Definition

ChEBI: Z-DEVD-FMK is a tetrapeptide consisting of Fmoc-L-aspartic acid 4-methyl ester, methyl L-alpha-glutamic acid 5-methyl ester, L-valine and the fluoromethyl ketone derived from the 1-carboxy group of L-aspartic acid 4-methyl ester coupled in sequence. It is a specific, irreversible caspase-3 inhibitor that also shows potent inhibition of caspase-6, caspase-7, caspase-8, and caspase-10. It has a role as an apoptosis inhibitor, an EC 3.4.22.56 (caspase-3) inhibitor and a neuroprotective agent.

General Description

A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 μg/75 μl) solution of Z-DEVD-FMK (Cat. No. 264156) in DMSO is also available.

Biological Activity

Cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumor cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo .

Biochem/physiol Actions

Cell permeable: yes

target

Caspase-3

References

1. garcia-calvo m, peterson ep, leiting b, ruel r, nicholson dw, thornberry na (1998) inhibition of human caspases by peptidebased and macromolecular inhibitors. j biol chem 273:32608–32613 2. thornberry na, rano ta, peterson ep, rasper dm, timkey t, garcia-calvo m, houtzager vm, nordstrom pa, roy s, vaillancourt jp, chapman kt, nicholson dw (1997) a combinatorial approach defines specificities of members of the caspase family and granzyme b. functional relationships established for key mediators of apoptosis. j biol chem 272:17907–17911 3. yakovlev ag, knoblach sm, fan l, fox gb, goodnight r, faden ai (1997) activation of cpp32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. j neurosci 17:7415–7424 4. clark rs, kochanek pm, watkins sc, chen m, dixon ce, seidberg na, melick j, loeffert je, nathaniel pd, jin kl, graham sh (2000) caspase-3 mediated neuronal death after traumatic brain injury in rats. j neurochem 74:740–753 5. s. m. knoblach, d. a. alroy et al, caspase inhibitor z-devd-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury, journal of cerebral blood flow & metabolism 24:1119–1132.

Z-DEVD-FMK Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-DEVD-FMK Suppliers

China 110 Japan 3 Switzerland 2 United Kingdom 5 United States 28 Global 148
Nacalai Tesque, Inc.
Tel
--
Fax
--
Email
info-tech@nacalai.co.jp
Country
Japan
ProdList
6046
Advantage
75
Wako Pure Chemical Industries, Ltd.
Tel
--
Fax
--
Email
labchem-tec@wako-chem.co.jp
Country
Japan
ProdList
6819
Advantage
80
Kanto Chemical Co., Inc.
Tel
--
Fax
--
Email
reag-info@gms.kanto.co.jp
Country
Japan
ProdList
6756
Advantage
74

210344-95-9, Z-DEVD-FMKRelated Search:

Z-DEVD-AFC Z-FA-FMK CASPASE-8 INHIBITOR II Z-Vad-fmk, non-methylated Z-PHE-DL-ALA-FLUOROMETHYLKETONE WZ3146 Belnacasan (VX-765) WZ8040 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Z-VAD-FMK Z-ASP-OME

  • Z-ASP-GLU-VAL-ASP-FLUOROMETHYLKETONE
  • Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-CH2F
  • Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FLUOROMETHYLKETONE
  • Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FMK
  • Z-ASP(OME)-GLU(OME)-VAL-DL-ASP(OME)-FLUOROMETHYLKETONE
  • Z-DEVD-FLUOROMETHYLKETONE
  • Z-DEVD-FMK
  • Z-D(OME)E(OME)VD(OME) FLUOROMETHYLKETONE
  • Z-D(OME)E(OME)VD(OME)-FMK
  • BENZYLOXYCARBONYL-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FLUOROMETHYLKETONE
  • CASPASE3/CPP32 INHIBITOR W-3
  • CASPASE-3, INHIBITOR
  • CASPASE-3 INHIBITOR2
  • Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem
  • AG-B-56189
  • CASPASE-3 INHIBITOR II; 210344-95-9; CASPASE-3 INHIBITOR; CTK8E8674; AG-B-56189; S7312;CASPASE-3 INHIBITOR;210344-95-9
  • CTK8E8674
  • S7312
  • CS-1505
  • CASPASE-3 INHIBITOR (FLUOROMETHYLKETONE)
  • CASPASE-3 INHIBITOR II
  • L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-α-aspartyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, 1,2-dimethyl ester
  • N-[(Phenylmethoxy)carbonyl]-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-valinamide 1,2-dimethyl ester
  • Caspase-2 Inhibitor Z-VDVAD-FMK
  • Z-DEVD-FMK USP/EP/BP
  • abs812077
  • Z-DEVD-FMK, Caspase-3 inhibitor
  • CBZ-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OM)
  • 210344-95-9
  • 210334-95-9
  • C30H41N4O12F
  • Inhibitors
  • Apoptosis
  • peptides
  • API
  • Caspases/Apoptosis
  • peptide
  • Caspase/Related Products
  • Pepetides