ChemicalBook > CAS DataBase List > Isopropyl acetate

Isopropyl acetate

Product Name
Isopropyl acetate
CAS No.
108-21-4
Chemical Name
Isopropyl acetate
Synonyms
IPAC;IPrOAc;propan-2-yl acetate;CH3COOCH(CH3)2;Ispropyl acetate;2-propylacetate;Isopropylacetat;2-acetoxypropane;2-Propyl acetate;ACETIC ACID ISOPROPYL ESTER
CBNumber
CB6852740
Molecular Formula
C5H10O2
Formula Weight
102.13
MOL File
108-21-4.mol
More
Less

Isopropyl acetate Property

Melting point:
-73 °C
Boiling point:
88.8 °C
Density 
0.872 g/mL at 25 °C(lit.)
vapor density 
3.5 (vs air)
vapor pressure 
47 mm Hg ( 20 °C)
refractive index 
n20/D 1.377(lit.)
FEMA 
2926 | ISOPROPYL ACETATE
Flash point:
62 °F
storage temp. 
Store below +30°C.
solubility 
1 M HCl: soluble50mg/mL, clear to slightly hazy, colorless
form 
Liquid
color 
Clear colorless
Odor
Pleasant, fruity; nonresidual.
Odor Threshold
0.16ppm
explosive limit
1.8%, 37°F
Odor Type
ethereal
Water Solubility 
2.90 g/100 mL
FreezingPoint 
-73.4℃
Sensitive 
Moisture Sensitive
JECFA Number
305
Merck 
14,5205
BRN 
1740761
Exposure limits
TLV-TWA 250 ppm (~950 mg/m3) (ACGIH, MSHA, and OSHA); TLV-STEL 310 ppm (~1185 mg/m3) (ACGIH); IDLH 16,000 ppm (NIOSH).
Stability:
Stable. Flammable - note low flash point. Incompatible with strong oxidizing agents, strong acids, nitrates, alkali metals. May attack some plastics and rubber.
LogP
1.03-1.18 at 20℃
CAS DataBase Reference
108-21-4(CAS DataBase Reference)
NIST Chemistry Reference
Acetic acid, 1-methylethyl ester(108-21-4)
EPA Substance Registry System
Isopropyl acetate (108-21-4)
More
Less

Safety

Hazard Codes 
F,Xi
Risk Statements 
11-36/37/38-67-66-36
Safety Statements 
16-26-36-33-29
RIDADR 
UN 1220 3/PG 2
WGK Germany 
1
RTECS 
AI4930000
Autoignition Temperature
894 °F
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29153900
Hazardous Substances Data
108-21-4(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 6.75 g/kg (Smyth)
IDLA
1,800 ppm
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P370+P378In case of fire: Use … for extinction.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W292605
Product name
Isopropyl acetate
Purity
≥99%, FCC
Packaging
1kg
Price
$76.5
Updated
2024/03/01
Sigma-Aldrich
Product number
W292605
Product name
Isopropyl acetate
Purity
≥99%, FCC
Packaging
9kg
Price
$311
Updated
2024/03/01
Sigma-Aldrich
Product number
W292605
Product name
Isopropyl acetate
Purity
≥99%, FCC
Packaging
20kg
Price
$565
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2109
Product name
Isopropyl acetate
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
3X1.2ML
Price
$185
Updated
2024/03/01
Sigma-Aldrich
Product number
90871
Product name
Isopropyl acetate
Purity
analytical standard
Packaging
5ML
Price
$102
Updated
2024/03/01
More
Less

Isopropyl acetate Chemical Properties,Usage,Production

Chemical Properties

Isopropyl acetate is a colourless liquid with an intense, fruity odor. On dilution, it has a sweet apple-like flavor. Miscible with most organic solvents such as alcohols, ketones and ethers. 2.9% (w/w) soluble in water at 20°C. Synthesized by direct acetylation of isopropyl alcohol in the presence of various catalysts: concentrated H2S04, diethyl sulfate, chlorosulfonic acid, and boron trifluoride.

Physical properties

Clear, colorless liquid with an aromatic odor. Experimentally determined detection and recognition odor threshold concentrations were 2.1 mg/m3 (500 ppbv) and 3.8 mg/m3 (910 ppbv), respectively (Hellman and Small, 1974).

Occurrence

Reported found in pineapple, pear, cocoa, apple, banana, black currants, grapes, melons, strawberry, cheddar cheese, beer, white wine, red wine, cocoa, honey, soybean, yellow passion fruit, beans, plum brandy and nectarines

Uses

Isopropyl acetate is used as a solvent for nitrocellulose, plastics, oils, and fats, and as a flavoring agent. Isopropyl Acetate is a widely used chemical solvent in organic and industrial syntheses. Also used in the dissolution of gallstones. Environmental contaminants; Food contaminants.

Definition

ChEBI: Isopropyl acetate is a branched-chain saturated fatty acid anion that is the conjugate base of isovaleric acid; reported to improve ruminal fermentation and feed digestion in cattle.

Preparation

Isopropyl acetate is prepared from propylene and anhydrous acetic acid in the presence of a catalyst . It may also be produced by direct acetylation of isopropyl alcohol in the presence of various catalysts; concentrated H2SO4, diethyl sulfate, chlorosulfonic acid and boron trifluoride.

Application

Isopropyl acetate is a solvent in chemical industry, especially for cellulose, plastics, waxes, resins, gums, paints, oil and fats. and also as flavoring agent. It is an active component of perfumes and printing inks. It is also employed as an extractant for the preparation of antibiotics, vitamins and hormones.

Aroma threshold values

Detection; 1.7 to 4.4 ppm

Taste threshold values

Taste characteristics at 60 ppm: ethereal, tutti-frutti, with a fruity apple and banana nuance

Synthesis Reference(s)

The Journal of Organic Chemistry, 39, p. 3728, 1974 DOI: 10.1021/jo00939a026

General Description

Isopropyl acetate appears as a clear colorless liquid. Flash point 40°F. Vapors are heavier than air. Contact with the material may irritate skin, eyes or mucous membranes. May be toxic by ingestion, inhalation and skin absorption. Used as a solvent.

Air & Water Reactions

Highly flammable. Less dense than water and slightly soluble in water.

Reactivity Profile

Isopropyl acetate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Isopropyl acetate can react vigorously with nitrates, strong oxidizers, strong alkalis and strong acids. Isopropyl acetate may also attack some forms of rubber, plastics and coatings. .

Health Hazard

Isopropyl acetate is an irritant to the eyes,nose, and throat. Liquid irritates eyes but causes no serious injury; may cause dermatitis; no serious effects if swallowed. The acute toxicity in laboratory animals was low. Exposure to highconcentrations in air or ingestion can produce narcotic effects. A 4-hour exposure to aconcentration of 32,000 ppm in air was fatalto rats (ACGIH 1986). The oral LD50 valuein rats is in the range 6000 mg/kg.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Flammability and Explosibility

Highly flammable

Source

Identified among 139 volatile compounds identified in cantaloupe (Cucumis melo var. reticulates cv. Sol Real) using an automated rapid headspace solid phase microextraction method (Beaulieu and Grimm, 2001).

Environmental Fate

Chemical/Physical. Hydrolyzes in water forming isopropyl alcohol and acetic acid (Morrison and Boyd, 1971). The estimated hydrolysis half-life at 25 °C and pH 7 is 8.4 yr (Mabey and Mill, 1978).
At an influent concentration of 1,000 mg/L, treatment with GAC resulted in an effluent concentration of 319 mg/L. The adsorbability of the carbon used was 137 mg/g carbon (Guisti et al., 1974).

Purification Methods

Wash the acetate with 50% aqueous K2CO3 (to remove acid), then with saturated aqueous CaCl2 (to remove any alcohol). Dry it with CaCl2 and fractionally distil it. [Beilstein 2 IV 141.]

Isopropyl acetate Preparation Products And Raw materials

Raw materials

Preparation Products

16,17-Epoxy-16-methyl pregn-9(11)-en-3-ol-20-one 19-CARBOXYANDROST-4-ENE-3,17-DIONE 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL- 5 A-CHLORO-6 B,19-EPOXY-3 B -HYDROXY-5 A-ANDROSTAN-17-ONE 6,9-Difluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate 4-(Aminosulfonyl)phenylboronic acid 9-Bromo-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-acetate 4-(2-KETO-1-BENZIMIDAZOLINYL)PIPERIDINE 1-METHANESULFONYL-PIPERAZINE 6alpha,9-difluoro-11beta,21-dihydroxypregna-1,4,16-triene-3,20-dione 21-acetate 5-CHLORO-6 B,19-EPOXY-5A -ANDROTANE-3,17-DIONE Oxendolone Estrone 3-Acetyloxy-16,17-epoxy-16-methylpregn-5-en-20-one 5-Azaindole 3,17,21-Trihydroxypregna-3,5,9(11)-trien-20-one 3,17,21-triacetate Aclatonium napadisilate 9-fluoro-11beta,21-dihydroxypregna-1,4,16-triene-3,20-dione 21-acetate 3,17-Dihydroxy-16-methylpregna-5,15-diene-20-one 3-acetate all-trans-Retinol ironic ion stabiliger CT^{1~7^} Benzyl acetate 19-HYDROXY-4-ANDROSTENE-3,17-DIONE Ethyl N-piperazinecarboxylate Pyridoxine hydrochloride 4-TERT-BUTYL-3-HYDROXY-2,6-DIMETHYLPHENYLACETONITRILE 16,17-Epoxy-3-hydroxy-16-methyl-pregn-9(11)-ene-20-one-3-acetate Triamcinolone 21-acetate 17-Ethinylandrost-5-ene-3,17-diol 16,17-Epoxy-3,17-dihydroxyestra-1,3,5(10)-triene-3,17-diacetate Tirofiban Dopamine hydrochloride Tetrabenzyl pyrophosphate Hydrocortisone 17-hydroxy-6-methylenepregn-4-ene-3,20-dione 17-acetate 9beta,11beta-epoxy-17,21-dihydroxypregn-4-ene-3,20-dione 3beta-hydroxy-5alpha-pregna-9(11),16-dien-20-one 3-acetate
More
Less

Isopropyl acetate Suppliers

Yixing Kaixin Chemical Co., Ltd
Tel
0510-87551792 13916598777
Email
kaixinchem@163.com
Country
China
ProdList
1
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24835
Advantage
65
Changzhou Xiaqing Technological Co., Ltd.
Tel
519-519-88783621 13906127738
Fax
+86-519-88495082
Email
xjq@xialichem.com
Country
China
ProdList
170
Advantage
70
Aikon International Limited
Tel
025-66113011 18112977050
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
16028
Advantage
58
Shanghai Boer Chemical Reagent Co., LTD
Tel
19102157732
Email
zhangmin@boerchina.net
Country
China
ProdList
7855
Advantage
58
Shandong Jinyueyuan New Material Co. Ltd
Tel
18615186228
Email
3404852510@qq.com
Country
China
ProdList
447
Advantage
58
Tangyuan Life Science (Shanghai) Co., Ltd
Tel
400-618-1121
Fax
400-618-1121
Email
sales@townyuan.com
Country
China
ProdList
2984
Advantage
58
Jinan Jinhong Chemical Co. LTD
Tel
15853193335
Email
578166395@qq.com
Country
China
ProdList
17
Advantage
58
Shandong Luoheng Chemical Products Co. , Ltd.
Tel
17362288188
Email
270788802@qq.com
Country
China
ProdList
39
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820 13031183356
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1392
Advantage
62
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12426
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9555
Advantage
66
Secco work (Beijing) chemical technology co., LTD
Tel
0566-8928158
Fax
010-69755668
Email
343367102@QQ.COM
Country
China
ProdList
360
Advantage
54
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9816
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
jiliang chemicals
Tel
21-62165282 15801962796;
Fax
021 61153784
Email
bidingchem@163.com
Country
China
ProdList
1157
Advantage
60
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3296
Advantage
57
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18736
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7815
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14443
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Henan Wanxiang Chemical Industry Co., Ltd.
Tel
0371-56669001 13949088811
Fax
0371-56669008
Email
Sales@58chem.cn
Country
China
ProdList
89
Advantage
62
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11714
Advantage
57
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9664
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9725
Advantage
55
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9872
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17779
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6139
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18216
Advantage
56
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9906
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8033
Advantage
55
Zouping Mingxing Chemical Co.,Ltd.
Tel
86-13605431940 13605431940
Fax
0086-0543-2240079
Email
zpmxchemical@126.com
Country
China
ProdList
2002
Advantage
62
Beijing Universal Century Technology Co., Ltd.
Tel
400-8706899
Fax
400-8706899
Email
hysj_bj.com
Country
China
ProdList
3585
Advantage
55
RiZhao LiDeShi Chemical Co., Ltd.
Tel
010-51268198
Fax
010-63833209
Email
leadershipchem@126.com
Country
China
ProdList
2549
Advantage
58
Mei Lan Industrial (Shanghai) Co., Ltd.
Tel
021-58958189
Fax
021-58957967
Email
wouchina@126.com
Country
China
ProdList
2671
Advantage
55
Shanghai GaoLang Chemical Technology Co., Ltd.
Tel
021-57340939 18017297327
Fax
021-37210791
Email
sales@gaolangchemical.com
Country
China
ProdList
888
Advantage
55
Shanghai ideal Industrial Co., Ltd.
Tel
021-58957966 18930537195
Fax
021-60899437
Email
wouchina@126.com
Country
China
ProdList
2873
Advantage
58
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ:800101999
Email
cdhxsj@163.com
Country
China
ProdList
13358
Advantage
58
GuangTuo Chemical (Shanghai) Co., Ltd.
Tel
021-60899189-8001 18918189673
Fax
021-60899304
Email
gtchem@126.com
Country
China
ProdList
2661
Advantage
58
Shaanxi Pioneer Biotech Co., Ltd.
Tel
13720616393;029-84385017-8003 13720616393
Fax
029-84385017
Email
sales@pioneerbiotech.com
Country
China
ProdList
1065
Advantage
56
Credit-Chem Co., Ltd.
Tel
400-821-5857 021-64326257
Fax
021-64393586 QQ;2798200800
Email
credit-chem@foxmail.com
Country
China
ProdList
5223
Advantage
58
More
Less

View Lastest Price from Isopropyl acetate manufacturers

Hebei Duling International Trade Co. LTD
Product
Isopropyl acetate 108-21-4
Price
US $100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2022-10-25
Shaanxi Haibo Biotechnology Co., Ltd
Product
Isopropyl acetate 108-21-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-09-07
Henan Bao Enluo International TradeCo.,LTD
Product
Isopropyl acetate 108-21-4
Price
US $10.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
50000tons
Release date
2023-08-11

108-21-4, Isopropyl acetate Related Search:


  • ISOPROPYL ACETATE
  • FEMA 2926
  • ISO-PROPYLE ACETATE
  • iso-propyl acetaate
  • ISOPROPYL ACETATE, STANDARD FOR GC
  • ISOPROPYL ACETATE 99+% FCC
  • ISOPROPYL ACETATE, 99.6+%
  • ISOPROPYL ACETATE GC STANDARD
  • PROPYL ISO, ACETATE
  • ACETIC ACID, 1-METHYLETHYL ESTER
  • ACETIC ACID ISOPROPYL ESTER
  • 1-METHYL ETHYL ACETATE
  • 2-acetoxypropane
  • 2-Methylethylethanoate
  • 2-Propyl acetate
  • 2-propylacetate
  • 2-propylethanoate
  • Acetate d'isopropyle
  • acetated’isopropyle
  • acetated’isopropyle(french)
  • Acetic acid, 2-propyl ester
  • CH3COOCH(CH3)2
  • Ethanoicacid,isopropylester
  • Isopropile(acetato di)
  • propylacetate(non-specificname)
  • sec-Propyl acetate
  • so-Propyl acetate
  • Isopropyl acetate, for analysis
  • Isopropyl acetate, pure, 99%
  • IPAC
  • Ispropyl acetate
  • propan-2-yl acetate
  • Isopropyl acetate, 99+%, for analysis
  • Ispropyl acetat
  • Isopropyl acetate, 99.5%
  • IPrOAc
  • Isopropyl acetate puriss. p.a., >=99.5% (GC)
  • Isopropyl acetate, 99%, pure
  • Isopropyl Acetate (1.2 mL/ampule
  • Isopropyl acetate, pure, 99% 1LT
  • Isopropyl acetate, pure, 99% 2.5LT
  • 1-Methylethylethanoate
  • isopropile(acetatodi)
  • Isopropyl ester of acetic acid
  • Isopropyl ethanoate
  • Isopropyl(acetate d')
  • isopropyl(acetated’)
  • Isopropylacetaat
  • Isopropylacetat
  • isopropyle(acetated’)(french)
  • Isopropylester kyseliny octove
  • isopropylesterkyselinyoctove
  • Isopropylethanoate
  • paracetat
  • Isopropyl acetate, pure, 99+%
  • ISOPROPYLACETATEESTER
  • Essigsureisopropylester
  • Isopropyl acetate, 99+%