ChemicalBook > CAS DataBase List > Isopropyl acetate

Isopropyl acetate

Product Name
Isopropyl acetate
CAS No.
108-21-4
Chemical Name
Isopropyl acetate
Synonyms
IPAC;IPrOAc;propan-2-yl acetate;CH3COOCH(CH3)2;Ispropyl acetate;2-propylacetate;Isopropylacetat;2-acetoxypropane;2-Propyl acetate;ACETIC ACID ISOPROPYL ESTER
CBNumber
CB6852740
Molecular Formula
C5H10O2
Formula Weight
102.13
MOL File
108-21-4.mol
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Isopropyl acetate Property

Melting point:
-73 °C
Boiling point:
88.8 °C
Density 
0.872 g/mL at 25 °C(lit.)
vapor density 
3.5 (vs air)
vapor pressure 
47 mm Hg ( 20 °C)
refractive index 
n20/D 1.377(lit.)
FEMA 
2926 | ISOPROPYL ACETATE
Flash point:
62 °F
storage temp. 
Store below +30°C.
solubility 
1 M HCl: soluble50mg/mL, clear to slightly hazy, colorless
form 
Liquid
color 
Clear colorless
Odor
Pleasant, fruity; nonresidual.
Odor Threshold
0.16ppm
Odor Type
ethereal
explosive limit
1.8%, 37°F
biological source
synthetic
Water Solubility 
2.90 g/100 mL
FreezingPoint 
-73.4℃
Sensitive 
Moisture Sensitive
JECFA Number
305
Merck 
14,5205
BRN 
1740761
Exposure limits
TLV-TWA 250 ppm (～950 mg/m3) (ACGIH, MSHA, and OSHA); TLV-STEL 310 ppm (～1185 mg/m3) (ACGIH); IDLH 16,000 ppm (NIOSH).
Stability:
Stable. Flammable - note low flash point. Incompatible with strong oxidizing agents, strong acids, nitrates, alkali metals. May attack some plastics and rubber.
LogP
1.03-1.18 at 20℃
CAS DataBase Reference
108-21-4(CAS DataBase Reference)
NIST Chemistry Reference
Acetic acid, 1-methylethyl ester(108-21-4)
EPA Substance Registry System
Isopropyl acetate (108-21-4)
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Safety

Hazard Codes 
F,Xi
Risk Statements 
11-36/37/38-67-66-36
Safety Statements 
16-26-36-33-29
RIDADR 
UN 1220 3/PG 2
WGK Germany 
1
RTECS 
AI4930000
Autoignition Temperature
894 °F
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29153900
Hazardous Substances Data
108-21-4(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 6.75 g/kg (Smyth)
IDLA
1,800 ppm
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P370+P378In case of fire: Use … for extinction.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W292605
Product name
Isopropyl acetate
Purity
≥99%, FCC
Packaging
1kg
Price
$76.5
Updated
2024/03/01
Sigma-Aldrich
Product number
W292605
Product name
Isopropyl acetate
Purity
≥99%, FCC
Packaging
9kg
Price
$311
Updated
2024/03/01
Sigma-Aldrich
Product number
W292605
Product name
Isopropyl acetate
Purity
≥99%, FCC
Packaging
20kg
Price
$565
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2109
Product name
Isopropyl acetate
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
3X1.2ML
Price
$185
Updated
2024/03/01
Sigma-Aldrich
Product number
90871
Product name
Isopropyl acetate
Purity
analytical standard
Packaging
5ML
Price
$102
Updated
2024/03/01
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Isopropyl acetate Chemical Properties,Usage,Production

Chemical Properties

Isopropyl acetate is a colourless liquid with an intense, fruity odor. On dilution, it has a sweet apple-like flavor. Miscible with most organic solvents such as alcohols, ketones and ethers. 2.9% (w/w) soluble in water at 20°C. Synthesized by direct acetylation of isopropyl alcohol in the presence of various catalysts: concentrated H2S04, diethyl sulfate, chlorosulfonic acid, and boron trifluoride.

Physical properties

Clear, colorless liquid with an aromatic odor. Experimentally determined detection and recognition odor threshold concentrations were 2.1 mg/m3 (500 ppbv) and 3.8 mg/m3 (910 ppbv), respectively (Hellman and Small, 1974).

Occurrence

Reported found in pineapple, pear, cocoa, apple, banana, black currants, grapes, melons, strawberry, cheddar cheese, beer, white wine, red wine, cocoa, honey, soybean, yellow passion fruit, beans, plum brandy and nectarines

Uses

Isopropyl acetate is used as a solvent for nitrocellulose, plastics, oils, and fats, and as a flavoring agent. Isopropyl Acetate is a widely used chemical solvent in organic and industrial syntheses. Also used in the dissolution of gallstones. Environmental contaminants; Food contaminants.

Definition

ChEBI: Isopropyl acetate is a branched-chain saturated fatty acid anion that is the conjugate base of isovaleric acid; reported to improve ruminal fermentation and feed digestion in cattle.

Preparation

Isopropyl acetate is prepared from propylene and anhydrous acetic acid in the presence of a catalyst . It may also be produced by direct acetylation of isopropyl alcohol in the presence of various catalysts; concentrated H2SO4, diethyl sulfate, chlorosulfonic acid and boron trifluoride.

Application

Isopropyl acetate is a solvent in chemical industry, especially for cellulose, plastics, waxes, resins, gums, paints, oil and fats. and also as flavoring agent. It is an active component of perfumes and printing inks. It is also employed as an extractant for the preparation of antibiotics, vitamins and hormones.

Aroma threshold values

Detection; 1.7 to 4.4 ppm

Taste threshold values

Taste characteristics at 60 ppm: ethereal, tutti-frutti, with a fruity apple and banana nuance

Synthesis Reference(s)

The Journal of Organic Chemistry, 39, p. 3728, 1974 DOI: 10.1021/jo00939a026

General Description

Isopropyl acetate appears as a clear colorless liquid. Flash point 40°F. Vapors are heavier than air. Contact with the material may irritate skin, eyes or mucous membranes. May be toxic by ingestion, inhalation and skin absorption. Used as a solvent.

Air & Water Reactions

Highly flammable. Less dense than water and slightly soluble in water.

Reactivity Profile

Isopropyl acetate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Isopropyl acetate can react vigorously with nitrates, strong oxidizers, strong alkalis and strong acids. Isopropyl acetate may also attack some forms of rubber, plastics and coatings. .

Health Hazard

Isopropyl acetate is an irritant to the eyes,nose, and throat. Liquid irritates eyes but causes no serious injury; may cause dermatitis; no serious effects if swallowed. The acute toxicity in laboratory animals was low. Exposure to highconcentrations in air or ingestion can produce narcotic effects. A 4-hour exposure to aconcentration of 32,000 ppm in air was fatalto rats (ACGIH 1986). The oral LD50 valuein rats is in the range 6000 mg/kg.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Flammability and Explosibility

Highly flammable

Source

Identified among 139 volatile compounds identified in cantaloupe (Cucumis melo var. reticulates cv. Sol Real) using an automated rapid headspace solid phase microextraction method (Beaulieu and Grimm, 2001).

Environmental Fate

Chemical/Physical. Hydrolyzes in water forming isopropyl alcohol and acetic acid (Morrison and Boyd, 1971). The estimated hydrolysis half-life at 25 °C and pH 7 is 8.4 yr (Mabey and Mill, 1978).
At an influent concentration of 1,000 mg/L, treatment with GAC resulted in an effluent concentration of 319 mg/L. The adsorbability of the carbon used was 137 mg/g carbon (Guisti et al., 1974).

Purification Methods

Wash the acetate with 50% aqueous K2CO3 (to remove acid), then with saturated aqueous CaCl2 (to remove any alcohol). Dry it with CaCl2 and fractionally distil it. [Beilstein 2 IV 141.]

Toxics Screening Level

The final ITSL for isopropyl acetate is 4,200 μg/m3, 8-hour average.

Isopropyl acetate Preparation Products And Raw materials

Raw materials

Acetic acid Isopropyl alcohol

Preparation Products

16,17-Epoxy-16-methyl pregn-9(11)-en-3-ol-20-one 19-CARBOXYANDROST-4-ENE-3,17-DIONE 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL- 5 A-CHLORO-6 B,19-EPOXY-3 B -HYDROXY-5 A-ANDROSTAN-17-ONE 6,9-Difluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate 4-(Aminosulfonyl)phenylboronic acid 9-Bromo-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-acetate 4-(2-KETO-1-BENZIMIDAZOLINYL)PIPERIDINE 1-METHANESULFONYL-PIPERAZINE 6alpha,9-difluoro-11beta,21-dihydroxypregna-1,4,16-triene-3,20-dione 21-acetate 5-CHLORO-6 B,19-EPOXY-5A -ANDROTANE-3,17-DIONE Oxendolone Estrone 3-Acetyloxy-16,17-epoxy-16-methylpregn-5-en-20-one 5-Azaindole 3,17,21-Trihydroxypregna-3,5,9(11)-trien-20-one 3,17,21-triacetate Aclatonium napadisilate 9-fluoro-11beta,21-dihydroxypregna-1,4,16-triene-3,20-dione 21-acetate 3,17-Dihydroxy-16-methylpregna-5,15-diene-20-one 3-acetate Vitamin A ironic ion stabiliger CT^{1～7^} Benzyl acetate 19-HYDROXY-4-ANDROSTENE-3,17-DIONE Ethyl N-piperazinecarboxylate Pyridoxine hydrochloride 4-TERT-BUTYL-3-HYDROXY-2,6-DIMETHYLPHENYLACETONITRILE 16,17-Epoxy-3-hydroxy-16-methyl-pregn-9(11)-ene-20-one-3-acetate Triamcinolone 21-acetate 17-Ethinylandrost-5-ene-3,17-diol 16,17-Epoxy-3,17-dihydroxyestra-1,3,5(10)-triene-3,17-diacetate Tirofiban Dopamine hydrochloride Tetrabenzyl pyrophosphate Hydrocortisone 17-hydroxy-6-methylenepregn-4-ene-3,20-dione 17-acetate 9beta,11beta-epoxy-17,21-dihydroxypregn-4-ene-3,20-dione 3beta-hydroxy-5alpha-pregna-9(11),16-dien-20-one 3-acetate
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Isopropyl acetate Suppliers

Americas 1 Argentina 2 Australia 1 Belgium 6 Canada 4 China 336 Czech Republic 1 Denmark 1 Europe 5 France 3 Germany 15 India 108 Ireland 1 Italy 4 Japan 12 Malaysia 1 Mexico 1 Norway 1 Poland 1 Singapore 3 Slovakia 1 South Korea 1 Spain 3 Switzerland 3 The Netherlands 5 Turkey 1 United Arab Emirates 3 United Kingdom 22 United States 99 Global 645
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View Lastest Price from Isopropyl acetate manufacturers

Qingdao RENAS Polymer Material Co., Ltd.
Product
Isopropyl acetate 108-21-4
Price
US $0.00/kg
Min. Order
20kg
Purity
99.0%
Supply Ability
20 tons
Release date
2024-07-02
Hebei Weibang Biotechnology Co., Ltd
Product
Isopropyl acetate 108-21-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-19
Hebei Chuanghai Biotechnology Co,.LTD
Product
Isopropyl acetate 108-21-4
Price
US $9.10/KG
Min. Order
1KG
Purity
99.5%
Supply Ability
10 ton
Release date
2024-08-13

108-21-4, Isopropyl acetate Related Search:

Vinyl acetate Isopropyl salicylate Isopropyl alcohol Isopropyl palmitate Isopropyl myristate Diisopropyl malonate Glatiramer acetate Tocopheryl acetate Titanium tetraisopropanolate Allyl phenoxyacetate Dimethyl succinate Butyl acetate Diisopropyl azodicarboxylate Ethyl 2-(Chlorosulfonyl)acetate Propyl acetate Tris(trimethylsilyl)phosphate Methyl acrylate Ethyl acetate Isopropyl Ethanoate

  • ISOPROPYL ACETATE
  • FEMA 2926
  • ISO-PROPYLE ACETATE
  • iso-propyl acetaate
  • ISOPROPYL ACETATE, STANDARD FOR GC
  • ISOPROPYL ACETATE 99+% FCC
  • ISOPROPYL ACETATE, 99.6+%
  • ISOPROPYL ACETATE GC STANDARD
  • PROPYL ISO, ACETATE
  • ACETIC ACID, 1-METHYLETHYL ESTER
  • ACETIC ACID ISOPROPYL ESTER
  • 1-METHYL ETHYL ACETATE
  • 2-acetoxypropane
  • 2-Methylethylethanoate
  • 2-Propyl acetate
  • 2-propylacetate
  • 2-propylethanoate
  • Acetate d'isopropyle
  • acetated’isopropyle
  • acetated’isopropyle(french)
  • Acetic acid, 2-propyl ester
  • CH3COOCH(CH3)2
  • Ethanoicacid,isopropylester
  • Isopropile(acetato di)
  • propylacetate(non-specificname)
  • sec-Propyl acetate
  • so-Propyl acetate
  • Isopropyl acetate, for analysis
  • Isopropyl acetate, pure, 99%
  • IPAC
  • Ispropyl acetate
  • propan-2-yl acetate
  • Isopropyl acetate, 99+%, for analysis
  • Ispropyl acetat
  • Isopropyl acetate, 99.5%
  • IPrOAc
  • Isopropyl acetate puriss. p.a., >=99.5% (GC)
  • Isopropyl acetate, 99%, pure
  • Isopropyl Acetate (1.2 mL/ampule
  • Isopropyl acetate, pure, 99% 1LT
  • Isopropyl acetate, pure, 99% 2.5LT
  • 1-Methylethylethanoate
  • isopropile(acetatodi)
  • Isopropyl ester of acetic acid
  • Isopropyl ethanoate
  • Isopropyl(acetate d')
  • isopropyl(acetated’)
  • Isopropylacetaat
  • Isopropylacetat
  • isopropyle(acetated’)(french)
  • Isopropylester kyseliny octove
  • isopropylesterkyselinyoctove
  • Isopropylethanoate
  • paracetat
  • Isopropyl acetate, pure, 99+%
  • ISOPROPYLACETATEESTER
  • Essigsureisopropylester
  • Isopropyl acetate, 99+%