ChemicalBook > CAS DataBase List > 2-Fluoroaniline

2-Fluoroaniline

Product Name
2-Fluoroaniline
CAS No.
348-54-9
Chemical Name
2-Fluoroaniline
Synonyms
2-fluroaniline;O-FLUOROANILINE;2-Fluorobenzenamine;AKOS 91139;2-Fluoranilin;2-FLUOROANILINE;FLUOROANILINE-2;AKOS BBS-00003628;1BO-Fluoroaniline;Aniline, 2-fluoro-
CBNumber
CB6853530
Molecular Formula
C6H6FN
Formula Weight
111.12
MOL File
348-54-9.mol
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2-Fluoroaniline Property

Melting point:
-29 °C
Boiling point:
182-183 °C(lit.)
Density 
1.151 g/mL at 25 °C(lit.)
vapor pressure 
1 hPa (20 °C)
refractive index 
n20/D 1.544(lit.)
Flash point:
140 °F
storage temp. 
Store below +30°C.
solubility 
17g/l
form 
Liquid
pka
3.2(at 25℃)
color 
Clear colorless
Specific Gravity
1.151
Water Solubility 
17 g/L (20°C)
BRN 
1524219
CAS DataBase Reference
348-54-9(CAS DataBase Reference)
NIST Chemistry Reference
Benzenamine, 2-fluoro-(348-54-9)
EPA Substance Registry System
o-Fluoroaniline (348-54-9)
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Safety

Hazard Codes 
Xn,T,Xi
Risk Statements 
22-37/38-41-36/38-33-23/24/25
Safety Statements 
26-39-37/39-45-36/37-28
RIDADR 
UN 2941 6.1/PG 3
WGK Germany 
2
RTECS 
BY1390000
Autoignition Temperature
600 °C
Hazard Note 
Toxic/Irritant
TSCA 
T
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214210
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F3401
Product name
2-Fluoroaniline
Purity
≥99%
Packaging
25G
Price
$33.2
Updated
2024/03/01
Sigma-Aldrich
Product number
F3401
Product name
2-Fluoroaniline
Purity
≥99%
Packaging
500G
Price
$344
Updated
2024/03/01
Sigma-Aldrich
Product number
8.20565
Product name
2-Fluoroaniline
Purity
for synthesis
Packaging
100mL
Price
$178
Updated
2024/03/01
Sigma-Aldrich
Product number
F3401
Product name
2-Fluoroaniline
Purity
≥99%
Packaging
100G
Price
$83.4
Updated
2022/05/15
TCI Chemical
Product number
F0032
Product name
2-Fluoroaniline
Purity
>99.0%(GC)
Packaging
25g
Price
$16
Updated
2024/03/01
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2-Fluoroaniline Chemical Properties,Usage,Production

Chemical Properties

2-Fluoroaniline is a clear colorless to brown liquid, toxic, insoluble in water, soluble in ethanol and ether, its vapor and air can form an explosive mixture, which can cause combustion and explosion in case of fire and high heat. Reacts with oxidants. Decomposed by high heat to release toxic gases.

Uses

2-Fluoroaniline (cas# 348-54-9) is a useful reagent for the synthesis of insecticides.

Application

2-Fluoroaniline can be used to synthesize thermosensitive dye FH-102, which is a black thermosensitive dye with wide application and excellent performance. The dye can be used in the production of terminal output printing paper of electronic computer, EEG recording paper, telephone fax paper and transparent thermal film for oil field.

Definition

ChEBI: 2-fluoroaniline is a derivative of aniline in which the hydrogen at position 2 has been substituted by fluorine. It is used as a pharmaceutical intermediate It is a primary arylamine and a fluoroaniline.

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 3415, 1984 DOI: 10.1016/S0040-4039(01)91034-2

General Description

Clear liquid with a mild sweet odor. Sinks in and mixes slowly with water.

Air & Water Reactions

Water soluble.

Reactivity Profile

2-Fluoroaniline is a base. Neutralizes acids to form salts plus water in an exothermic reaction. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Health Hazard

Inhalation or ingestion causes bluish tint to fingernails, lips and ears indicative of cyanosis; headache, drowsiness, and nausea, followed by unconsciousness. Liquid can be absorbed through skin and cause similar symptoms. Contact with eyes causes irritation.

Fire Hazard

Special Hazards of Combustion Products: Irritating and toxic hydrogen fluoride and oxides of nitrogen may form in fires.

Biological Activity

The metabolism and excretion of the xenobiotic compound 2-fluoroaniline is important due to human exposure in manufacturing. It is found to be very efficiently metabolized, primarily by 4-hydroxylation with subsequent sulfate or glucuronide formation. N-Acetylation is also observed. at least 80% of the dose is excreted in the urine within 24 hr. 2-Fluoroaniline exerts its nephrotoxic effect through 4-hyroxylation and subsequent p-benzoquinonimine formation.

Metabolic pathway

2-Fluoro and 3-fluoroanilines are preferentially hydroxylated at the para-position, and 4-fluoroaniline is both p- and o-hydroxylated to a significant extent by rat liver microsomes and is not accompanied with an NIH shift to give 4-hydroxyl-3-fluoroaniline.

2-Fluoroaniline Preparation Products And Raw materials

Raw materials

Ethyl 2-fluoropropionate 2-Nitrochlorobenzene Potassium fluoride Hydrogen

Preparation Products

Flufenoxuron carfentrazone-ethyl 4-Bromo-2-fluorobenzonitrile 2-FLUOROPHENYL ISOCYANATE 1-(2-FLUOROPHENYL)PIPERAZINE HYDROCHLORIDE
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2-Fluoroaniline Suppliers

Americas 1 Australia 1 Belgium 2 Canada 3 China 335 Europe 3 France 2 Germany 8 India 51 Indonesia 1 Italy 1 Japan 7 Slovakia 1 South Africa 1 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 2 United Kingdom 19 United States 52 Global 494
Pure Chemistry Scientific Inc.
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View Lastest Price from 2-Fluoroaniline manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
2-Fluoroaniline 348-54-9
Price
US $30.00-10.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-11-23
Henan Fengda Chemical Co., Ltd
Product
2-Fluoroaniline 348-54-9
Price
US $50.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-22
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
Product
2-Fluoroaniline 348-54-9
Price
US $25.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
50000kg/month
Release date
2022-01-24

348-54-9, 2-FluoroanilineRelated Search:

o-Anisidine 2-BENZOYLACETANILIDE Tris(hydroxymethyl)aminomethane POLYANILINE O-Tolidine o-Toluidine 3-Aminobenzotrifluoride 2-Chloroaniline Diphenylamine Fluorobenzene Benzidine 2,6-Difluoroaniline 2-Aminobenzotrifluoride Glycine 4-(Trifluoromethoxy)aniline 3-Chloro-4-fluoroaniline 6-Aminocaproic acid 3-Aminophenol

  • 2-FLUOROANILINE
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  • 1BO-Fluoroaniline
  • Aniline, 2-fluoro-
  • Aniline, o-fluoro-
  • 1,2-fluorobenzenamine
  • 2-fluoro-benzenamin
  • 2-Fluorobenzenamine
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  • 2-Fluoro-phenylamine
  • 2-Fluoroaniline, 97+%
  • O-FLUOROANILINE
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  • 2-Aminofluorobenzene
  • 2-Fluoroaniline ISO 9001：2015 REACH
  • 2-Fluoroaniline pure, 98%
  • Telmisartan Impurity U
  • Abemaciclib Impurity 10
  • 348-54-9
  • 48-54-9
  • 348-59-9
  • FC6H4NH2
  • C2 to C6
  • Building Blocks
  • Amines
  • Organic Building Blocks
  • Nitrogen Compounds
  • Fluoro-Aromatics
  • Anilines, Aromatic Amines and Nitro Compounds
  • Fluorobenzene
  • Heterocyclic Compounds
  • Benzene derivatives
  • Fluorobenzene Series
  • Fluorine series
  • amine | alkyl Fluorine