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PAC1

Product Name
PAC1
CAS No.
315183-21-2
Chemical Name
PAC1
Synonyms
PAC1;DUSP2;PAC1-R;CS-243;PAC1（b）;ADCYAP1R1;PAC-1,PAC1;PAC-1 10MG;PAC 1, >=98%;Pac1 receptor
CBNumber
CB71075505
Molecular Formula
C23H28N4O2
Formula Weight
392.49
MOL File
315183-21-2.mol
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PAC1 Property

Density 
1.14
storage temp. 
Store at +4°C
solubility 
DMSO: ≥10mg/mL
form 
solid
pka
8.82±0.40(Predicted)
color 
white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol must be stored under inert gas at -80°C and will be stable for up to 2 months.
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-36/37/38-50/53
Safety Statements 
26-36/37-60-61
RIDADR 
UN 3077
WGK Germany 
3
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H400Very toxic to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P0115
Product name
PAC-1
Purity
≥98% (HPLC)
Packaging
5mg
Price
$118
Updated
2024/03/01
Sigma-Aldrich
Product number
P0115
Product name
PAC-1
Purity
≥98% (HPLC)
Packaging
25mg
Price
$384
Updated
2024/03/01
Sigma-Aldrich
Product number
SAB1301755
Product name
ANTI-DUSP2 (C-TERM) antibody produced in rabbit
Purity
IgG fraction of antiserum, buffered aqueous solution
Packaging
400μL
Price
$461
Updated
2023/01/07
Cayman Chemical
Product number
10009317
Product name
PAC-1
Purity
≥98%
Packaging
25mg
Price
$108
Updated
2024/03/01
Cayman Chemical
Product number
10009317
Product name
PAC-1
Purity
≥98%
Packaging
50mg
Price
$201
Updated
2024/03/01
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PAC1 Chemical Properties,Usage,Production

Description

PAC-1 (315183-21-2) is a procaspase-activating compound, directly activating procaspase-3, producing caspase-3, EC50=0.22 μM.1 It is less potent at activating procaspase-7, EC50=4.5 μM. It induces apoptosis in a variety of cancer cell lines. The mechanism of activation involves sequestering inhibitory zinc ions thus allowing procaspase-3 to autoactivate.2?? Sensitizes cancer cells to various chemotherapeutic agents.3

Uses

PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM.

Biological Activity

Procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC 50 = 0.22 μ M). Also activates procaspase-7 in a less efficient manner (EC 50 = 4.5 μ M). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC 50 values are 0.003-1.41 and 5.02-9.98 μ M respectively).

storage

+4°C

References

1) Putt et al. (2006), Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy; Nat. Chem. Biol., 2 543 2) Peterson et al. (2009), PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition; J. Mol. Biol., 388 144 3) Bolham et al. (2016), Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with diverse Chemotherapeutics; ACS Cent. Sci., 2 545

PAC1 Preparation Products And Raw materials

Raw materials

Preparation Products

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PAC1 Suppliers

Canada 1 China 103 Germany 1 India 1 Ukraine 1 United Kingdom 3 United States 22 Global 132
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Carbosynth Limited
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6581
Advantage
61
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

315183-21-2, PAC1Related Search:

AC-VDVAD-PNA Z-VAD-FMK Bortezomib LY2109761 Paclitaxel Obatoclax mesilate 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Ruxolitinib AC-VEID-AMC Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE Z-YVAD-AFC ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL AC-VDVAD-CHO AC-DEVD-AFC AC-DEVD-CHO AC-LEHD-AFC AC-LEU-GLU-THR-ASP-AFC PAC1

  • PAC1
  • 4-(Phenylmethyl)-1-piperazineaceticacid[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide
  • PAC1,4-(PhenylMethyl)-1-piperazineaceticacid[[2-hydroxy-3-(2-propenyl)phenyl]Methylene]hydrazide
  • 4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide
  • PAC-1,PAC1
  • Procaspase activating coMpound 1
  • (E)-N'-(3-allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide
  • 4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide PAC-1
  • PAC 1 4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide
  • (4-Benzylpiperazino)acetic acid (3-allyl-2-hyroxybenzylidene)hydrazide
  • 1-Piperazineacetic acid, 2-(phenylmethyl)-,[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hyrrazide
  • ADCYAP1R1
  • Pac1 receptor
  • Pac1 receptors
  • PAC1-R
  • PACAP receptor 1
  • ANTI-DUSP2 (C-TERM) antibody produced in rabbit
  • Dual specificity protein phosphatase 2
  • Dual specificity protein phosphatase PAC-1
  • DUSP2
  • Anti-DUSP2 (C-terminal) antibody produced in rabbit
  • PAC 1, >=98%
  • PAC-1 10MG
  • PAC-1, 98%, a procaspase-3 activatior
  • CS-243
  • PAC 1 - Procaspase activating compound 1
  • 1-Piperazineacetic acid, 4-(phenylmethyl)-, 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide
  • PAC-1 >=98% (HPLC)
  • PAC1 USP/EP/BP
  • PAC-1 (VO-100)
  • N'-(3-Allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide
  • PAC1（b）
  • N'-(3-Allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide
  • 315183-21-2
  • Inhibitor
  • Inhibitors