2-Amino-4-chloromethythiazole hydrochloride

Product Name: 2-Amino-4-chloromethythiazole hydrochloride
CAS No.: 59608-97-8
Chemical Name: 2-Amino-4-chloromethythiazole hydrochloride
Synonyms: 2-thiazolamine, 4-(chloromethyl)-;2-AMino-4-chloroMethythiazole, HCl;2-AMINO-4-(CHLOROMETHYL)THIAZOLE HCI;2-AMINO-4-(CHLOROMETHYL)THIAZOLE HCL;2-AMINO-4-CHLOROMETHYTHIAZOLE HYDROCHLORIDE;4-CHLOROMETHYL-THIAZOL-2-YLAMINE HYDROCHLORIDE;2-AMINO-4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE;2-ThiazolaMine,4-(chloroMethyl)-, hydrochloride;4-(chloromethyl)-1,3-thiazol-2-amine hydrochloride;2-Amino-4-(chloromethyl)-1,3-thiazole hydrochloride
CBNumber: CB7123742
Molecular Formula: C4H6Cl2N2S
Formula Weight: 185.07
MOL File: 59608-97-8.mol

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2-Amino-4-chloromethythiazole hydrochloride Property

Melting point:: 141-143 °C(Solv: ethanol (64-17-5))
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
Appearance: White to off-white Solid
CAS DataBase Reference: 59608-97-8(CAS DataBase Reference)
EPA Substance Registry System: 2-Thiazolamine, 4-(chloromethyl)-, monohydrochloride (59608-97-8)

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Safety

Hazard Codes: Xi
Risk Statements: 43
Safety Statements: 36/37
HazardClass: IRRITANT
HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SYX00295
Product name: 2-Amino-4-(chloromethyl)thiazole hydrochloride
Packaging: 1g
Price: $107
Updated: 2025/07/31

TRC

Product number: C587905
Product name: 4-(Chloromethyl)thiazol-2-amineHydrochloride
Packaging: 500mg
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 012092
Product name: 4-Chloromethyl-thiazol-2-ylaminehydrochloride
Packaging: 5g
Price: $94
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: COR0001610
Product name: 2-AMINO-4-CHLOROMETHYTHIAZOLE HYDROCHLORIDE
Purity: 95.00%
Packaging: 2.5G
Price: $1091.99
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: COR0001610
Product name: 2-AMINO-4-CHLOROMETHYTHIAZOLE HYDROCHLORIDE
Purity: 95.00%
Packaging: 5G
Price: $1819.13
Updated: 2021/12/16

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2-Amino-4-chloromethythiazole hydrochloride Chemical Properties,Usage,Production

Uses

2-Amino-4-chloromethyl thiazole hydrochloride is an α-thiophene derivative, which is widely used in synthetic medicines, pesticides, dyes, chemical reagents, polymer additives, etc.

Synthesis

17356-08-0

534-07-6

59608-97-8

The general procedure for the synthesis of 2-amino-4-chloromethylthiazole hydrochloride from the compound (CAS: 17356-08-0) and 1,3-dichloroacetone was carried out as follows: a mixture of 1,3-dichloroacetone (380.9 g, 3 mol), thiourea (228.3 g, 3 mol), and isopropanol (3.6 L) was stirred at 40 °C in an inert atmosphere until a clarified solution. Subsequently, the reaction mixture was continued to be stirred at room temperature overnight to induce crystallization of the product. Upon completion of the reaction, the mixture was cooled to -20 °C to promote complete crystallization and the product was subsequently isolated by filtration. The resulting crystals were washed with cold isopropanol (0.4 L) and finally dried under vacuum to afford 2-amino-4-chloromethylthiazole hydrochloride as white crystals (408 g, 73.5% yield).

References

[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 21, p. 9686 - 9720
[2] Patent: WO2009/15193, 2009, A1. Location in patent: Page/Page column 44
[3] Bollettino Chimico Farmaceutico, 1995, vol. 134, # 11, p. 639 - 643
[4] Patent: WO2008/11191, 2008, A1. Location in patent: Page/Page column 36
[5] Patent: EP3018125, 2016, A1. Location in patent: Paragraph 0753-0755

2-Amino-4-chloromethythiazole hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-4-chloromethythiazole hydrochloride Suppliers

Canada 1 China 104 Germany 2 India 2 United Kingdom 5 United States 20 Global 134

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View Lastest Price from 2-Amino-4-chloromethythiazole hydrochloride manufacturers

Career Henan Chemical Co

Product: 2-Amino-4-chloromethythiazole hydrochloride 59608-97-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: 1ton
Release date: 2019-12-18

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2-AMINO-4-(CHLOROMETHYL)THIAZOLE HCI

2-thiazolamine, 4-(chloromethyl)-

4-(chloromethyl)-1,3-thiazol-2-amine hydrochloride

4-(Chloromethyl)-1,3-thiazol-2-ylamine hydrochloride

2-AMino-4-chloroMethythiazole, HCl

2-ThiazolaMine,4-(chloroMethyl)-, hydrochloride

2-AMINO-4-(CHLOROMETHYL)THIAZOLE HCL

2-AMINO-4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE

2-AMINO-4-CHLOROMETHYTHIAZOLE HYDROCHLORIDE

4-CHLOROMETHYL-THIAZOL-2-YLAMINE HYDROCHLORIDE

2-Amino-4-(chloromethyl)-1,3-thiazole hydrochloride

59608-97-8

C4H5ClN2SHCl

C4H6Cl2N2S

Thiazole