ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE

Product Name: ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE
CAS No.: 41731-52-6
Chemical Name: ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE
Synonyms: Ethyl 2-chloro-4-thiazolecarboxylate;ETHYL 2-CHLOROTHIAZOLE-4-CARBOXYLATE;2-Chloro-4-(ethoxycarbonyl)-1,3-thiazole;ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE;2-Chlorothiazole-4-carboxylic acid ethyl ester;2-chloro-4-Thiazolecarboxylic acid ethyl ester;2-Chloro-thiazole-4-carboxylic acid Methyl ester;4-Thiazolecarboxylic acid, 2-chloro-, ethyl ester
CBNumber: CB71517960
Molecular Formula: C6H6ClNO2S
Formula Weight: 191.64
MOL File: 41731-52-6.mol

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ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE Property

Boiling point:: 283.9℃
Density: 1.383
Flash point:: 125.5℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.50±0.10(Predicted)
Appearance: Light yellow to yellow Solid
InChI: InChI=1S/C6H6ClNO2S/c1-2-10-5(9)4-3-11-6(7)8-4/h3H,2H2,1H3
InChIKey: GILVNZWYCBUGMT-UHFFFAOYSA-N
SMILES: S1C=C(C(OCC)=O)N=C1Cl

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Safety

HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B124780
Product name: Ethyl 2-chlorothiazole-4-carboxylate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: B124780
Product name: Ethyl 2-chlorothiazole-4-carboxylate
Packaging: 500mg
Price: $110
Updated: 2021/12/16

Ark Pharm

Product number: P000167533
Product name: Ethyl 2-chlorothiazole-4-carboxylate
Purity: 95%
Packaging: 100mg
Price: $7
Updated: 2021/12/16

Ark Pharm

Product number: P000167533
Product name: Ethyl 2-chlorothiazole-4-carboxylate
Purity: 95%
Packaging: 250mg
Price: $10
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: C11740
Product name: 2-Chlorothiazole-4-carboxylicacidethylester
Purity: 95%
Packaging: 1g
Price: $15
Updated: 2021/12/16

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ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

5398-36-7

41731-52-6

General procedure for the synthesis of ethyl 2-chlorothiazole-4-carboxylate from ethyl 2-aminothiazole-4-carboxylate: ethyl 2-aminothiazole-4-carboxylate (306 mg, 1.78 mmol) and cuprous chloride (CuCl, 238 mg, 2.4 mmol) were suspended in concentrated hydrochloric acid (8 mL). The mixture was cooled in a salt/ice bath. A solution of pre-cooled sodium nitrite (NaNO2, 166 mg, 2.4 mmol) in water (2 mL) was added slowly over 10 minutes. The reaction mixture was allowed to gradually warm up to room temperature over 1 h and stirring was continued for 1 h. The reaction mixture was allowed to warm up to room temperature over 1 h and stirring was continued for 1 h. Upon completion of the reaction, water was added to dilute it and the aqueous phase was extracted with ethyl acetate (EtOAc, 3 x 10 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give the target product ethyl 2-chlorothiazole-4-carboxylate. Yield: 251 mg, 74% yield; liquid chromatography-mass spectrometry (LC/MS) retention time (tr) 1.06 min; mass spectrometry (electrospray positive ionization mode, ES+) m/z 192, 194 ([M+H]+); 1H NMR (250 MHz, CDCl3) δ 1.41 (t, 3H), 4.43 (q, 2H), 8.08 (s, 1H). 1H).

References

[1] Patent: WO2005/80367, 2005, A1. Location in patent: Page/Page column 109
[2] Organic Letters, 2013, vol. 15, # 20, p. 5390 - 5393
[3] Patent: US2013/178470, 2013, A1. Location in patent: Paragraph 0106
[4] Organic and Biomolecular Chemistry, 2012, vol. 10, # 30, p. 5764 - 5768
[5] Helvetica Chimica Acta, 1944, vol. 27, p. 1432,1433

ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE Suppliers

China 100 India 5 United Kingdom 1 United States 11 Global 117

Pure Chemistry Scientific Inc.

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View Lastest Price from ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Ethyl 2-chloro-1,3-thiazole-4-carboxylate 41731-52-6
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99% min
Supply Ability: 100kg
Release date: 2025-08-18

Career Henan Chemical Co

Product: ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE 41731-52-6
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2020-01-14

41731-52-6, ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATERelated Search:

5-Bromopicolinic acid Terpinyl acetate Oseltamivir phosphate 2,5-Dibromo-3-nitropyridine 2-PYRIDYLTHIOUREA 2-tert-Butyl-1,4-benzoquinone 5-Fluorotryptamine hydrochloride RARECHEM AL BI 1318 Ethyl 2-amino-1,3-thiazole-4-carboxylate Ethyl 2-bromothiazole-4-carboxylate 2-Methyl-1,3-thiazole-4-carboxylic acid ETHYL 2-METHYLTHIAZOLE-4-CARBOXYLATE 2-PHENYL-1,3-THIAZOLE-4-CARBOXYLIC ACID 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLIC ACID 2-Chlorothiazole METHYL 2-CHLORO-4-THIAZOLECARBOXYLATE ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE 2-Chloro-4-formylthiazole

ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE

ETHYL 2-CHLOROTHIAZOLE-4-CARBOXYLATE

2-Chlorothiazole-4-carboxylic acid ethyl ester

Ethyl 2-chloro-4-thiazolecarboxylate

2-Chloro-thiazole-4-carboxylic acid Methyl ester

2-chloro-4-Thiazolecarboxylic acid ethyl ester

2-Chloro-4-(ethoxycarbonyl)-1,3-thiazole

4-Thiazolecarboxylic acid, 2-chloro-, ethyl ester

41731-52-6

Building Blocks

Thiazole