2-Chloro-6-pyrazinecarboxylic acid methyl ester
- Product Name
- 2-Chloro-6-pyrazinecarboxylic acid methyl ester
- CAS No.
- 23611-75-8
- Chemical Name
- 2-Chloro-6-pyrazinecarboxylic acid methyl ester
- Synonyms
- Methyl 6-chloropyrazine-2-carboxylate;ethyl 6-chloropyrazine-2-carboxylate;m90108;6-Chloro-pyrazine-2-c;6-Chloro-pyrazine-2-carbo...;6-Chloro-pyrazine -2-carboxylate;METHYL 6-CHLORO-2-PYRAZINECARBOXYLATE;Methyl 2-chloropyrazine-6-carboxylate;Methyl6-chloropyrazine-2-carboxylate,95%;Methyl 6-chloropyrazine-2-carboxylate 97+%
- CBNumber
- CB72322112
- Molecular Formula
- C6H5ClN2O2
- Formula Weight
- 172.57
- MOL File
- 23611-75-8.mol
2-Chloro-6-pyrazinecarboxylic acid methyl ester Property
- Melting point:
- 40-41 °C
- Boiling point:
- 60-70 °C(Press: 30 Torr)
- Density
- 1.372±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.28±0.10(Predicted)
- form
- Solid
- Appearance
- Light yellow to brown Solid
- InChI
- InChI=1S/C6H5ClN2O2/c1-11-6(10)4-2-8-3-5(7)9-4/h2-3H,1H3
- InChIKey
- MVVYUJFEXRODQA-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)=NC(Cl)=CN=C1
Safety
- HS Code
- 2933119000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M340408
- Product name
- Methyl6-Chloropyrazine-2-carboxylate
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 068901
- Product name
- Methyl 6-chloropyrazine-2-carboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 068901
- Product name
- Methyl 6-chloropyrazine-2-carboxylate
- Purity
- >95%
- Packaging
- 5g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- J98485
- Product name
- 2-Chloro-6-pyrazinecarboxylicacidmethylester
- Packaging
- 10g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- J98485
- Product name
- 2-Chloro-6-pyrazinecarboxylicacidmethylester
- Packaging
- 25g
- Price
- $220
- Updated
- 2021/12/16
2-Chloro-6-pyrazinecarboxylic acid methyl ester Chemical Properties,Usage,Production
Synthesis
770-00-3
23611-75-8
The product of Example 1D (7.18 g, 45.9 mmol) was taken as raw material and dissolved in dichlorosulfoxide (SOCl2, 50 mL, 687 mmol). The reaction mixture was heated to reflux and kept for 8 hours and then cooled to room temperature. Excess SOCl2 was evaporated under reduced pressure followed by slow addition of water (50 mL) at 0 °C to quench the reaction. The reaction mixture was neutralized with 1 M aqueous potassium carbonate (K2CO3, aq), followed by multiple extractions with dichloromethane (CH2Cl2, 5 × 100 mL). All organic phase extracts were combined, washed with saturated saline (100 mL), dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: 5% ethyl acetate in dichloromethane solution, Rf=0.35) to afford methyl 6-chloropyrazine-2-carboxylate as a thick oil, which gradually solidified after standing (7.16 g, 67% yield). The product was characterized by 1H NMR (DMSO-d6, 300 MHz): δ 3.94 (s, 3H), 9.07 (s, 1H), 9.19 (s, 1H). Mass spectrum (DCI/NH3) showed m/z 190 (M+NH4)+.
References
[1] Patent: US2009/281118, 2009, A1. Location in patent: Page/Page column 10-11
[2] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 22, p. 7816 - 7825
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 21, p. 7678 - 7692
2-Chloro-6-pyrazinecarboxylic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-6-pyrazinecarboxylic acid methyl ester Suppliers
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View Lastest Price from 2-Chloro-6-pyrazinecarboxylic acid methyl ester manufacturers
- Product
- Methyl 6-chloropyrazine-2-carboxylate 23611-75-8
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- 2-Chloro-6-pyrazinecarboxylic acid methyl ester 23611-75-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 800 tons
- Release date
- 2020-04-28
- Product
- 2-Chloro-6-pyrazinecarboxylic acid methyl ester 23611-75-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-01