ChemicalBook > CAS DataBase List > Aminooxy-PEG4-Propargyl
Aminooxy-PEG4-Propargyl
- Product Name
- Aminooxy-PEG4-Propargyl
- CAS No.
- 1835759-78-8
- Chemical Name
- Aminooxy-PEG4-Propargyl
- Synonyms
- Aminooxy-TEG-propyne;Aminooxy-PEG4-Propargyl;O-(3,6,9,12-Tetraoxapentadec-14-yn-1-yl)hydroxylamine;Hydroxylamine, O-3,6,9,12-tetraoxapentadec-14-yn-1-yl-
- CBNumber
- CB73162838
- Molecular Formula
- C11H21NO5
- Formula Weight
- 247.29
- MOL File
- 1835759-78-8.mol
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Aminooxy-PEG4-Propargyl Property
- Boiling point:
- 353.6±37.0 °C(Predicted)
- Density
- 1.078±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, sealed storage, away from moisture and light
- form
- Liquid
- pka
- 4.21±0.70(Predicted)
- color
- Colorless to light yellow
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Aminooxy-PEG4-Propargyl Chemical Properties,Usage,Production
Description
Aminooxy-PEG4-propargyl is a aldehyde reactive crosslinker. The aminooxy group reacts with an aldehyde or ketone group to form a stable oxime linkage. The propargyl group is reactive with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.
Uses
Aminooxy-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Aminooxy-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Aminooxy-PEG4-Propargyl Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Aminooxy-PEG4-Propargyl manufacturers
Xian confluore Biological Technology Co., Ltd.
- Product
- Aminooxy-PEG4-propargyl 1835759-78-8
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-22
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