4-Bromoisoquinoline
- Product Name
- 4-Bromoisoquinoline
- CAS No.
- 1532-97-4
- Chemical Name
- 4-Bromoisoquinoline
- Synonyms
- NSC 56333;4-BromoisoquinoL;4-Bromoisoquinoli;4-Bromoisquinoline;4-bromoisoqunoline;4-BROMOISOQUINOLINE;Isoquinoline, 4-broMo-;LABOTEST-BB LT01143353;4-Bromoisoquinoline >4-Isoquinolinyl Bromide
- CBNumber
- CB7457317
- Molecular Formula
- C9H6BrN
- Formula Weight
- 208.05
- MOL File
- 1532-97-4.mol
4-Bromoisoquinoline Property
- Melting point:
- 40-43 °C (lit.)
- Boiling point:
- 280-285 °C (lit.)
- Density
- 1.5617 (rough estimate)
- refractive index
- 1.6641 (estimate)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform, Methanol
- pka
- 3.30±0.10(Predicted)
- form
- Crystalline Solid
- color
- White to light beige
- BRN
- 114431
- InChI
- InChI=1S/C9H6BrN/c10-9-6-11-5-7-3-1-2-4-8(7)9/h1-6H
- InChIKey
- SCRBSGZBTHKAHU-UHFFFAOYSA-N
- SMILES
- C1C2=C(C=CC=C2)C(Br)=CN=1
- CAS DataBase Reference
- 1532-97-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Isoquinoline, 4-bromo-(1532-97-4)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-21/22-20/21/22
- Safety Statements
- 26-37/39-36/37/39-22-36
- WGK Germany
- 3
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B70202
- Product name
- 4-Bromoisoquinoline
- Purity
- 98%
- Packaging
- 10g
- Price
- $69.7
- Updated
- 2025/07/31
- Product number
- B70202
- Product name
- 4-Bromoisoquinoline
- Purity
- 98%
- Packaging
- 25g
- Price
- $142.12
- Updated
- 2025/07/31
- Product number
- B0930
- Product name
- 4-Bromoisoquinoline
- Purity
- >98.0%(GC)
- Packaging
- 10g
- Price
- $69
- Updated
- 2025/07/31
- Product number
- B0930
- Product name
- 4-Bromoisoquinoline
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $138
- Updated
- 2025/07/31
- Product number
- 004802
- Product name
- 4-Bromoisoquinoline
- Packaging
- 1g
- Price
- $312
- Updated
- 2021/12/16
4-Bromoisoquinoline Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Solid
Uses
Shows selective inhibition of cAMP-dependent protein kinase
Preparation
2-Alkynyl benzyl azides could smoothly undergo an electrocyclic reaction catalyzed by palladium to afford either 4-bromoisoquinoline or 4-bromoisquinolones selectively under different conditions. 4-Bromoisoquinoline was synthesised in the presence of PdBr2/CuBr2/LiBr in MeCN, and 4-bromoisoquinolone was selectively produced with PdBr2/CuBr2/HOAc in CH2ClCH2Cl[1].
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 10, p. 409, 1973 DOI: 10.1002/jhet.5570100326
Synthesis
119-65-3
1532-97-4
Synthesis of Intermediate-12: 3-Bromoisoquinoline: To a stirred solution of isoquinoline (24 g, 186 mmol) in acetic acid (50 mL) was slowly added N-bromosuccinimide (NBS, 36.2 g, 204.6 mmol) at room temperature. The reaction mixture was heated to 100 °C and the reaction was stirred at this temperature overnight. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure to remove the solvent. The resulting crude product was purified by fast column chromatography (eluent: 5% ethyl acetate/hexane) to give 4-bromoisoquinoline (9.2 g, 23.8% yield) as an oil.
References
[1] Hong-ping Zhang, Hongzhan Xiao, Hong‐Yan Li. “A Selective Synthesis of 4-Bromoisoquinoline and 4-Bromoisquinolone.” Journal of Chemical Research-s (2013).
4-Bromoisoquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Bromoisoquinoline manufacturers
- Product
- 4-Bromoisoquinoline 1532-97-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-12
- Product
- 4-Bromoisoquinoline 1532-97-4
- Price
- US $30.00-10.00/kg
- Min. Order
- 10kg
- Purity
- 99%
- Supply Ability
- 100000kg
- Release date
- 2024-08-14
- Product
- 4-Bromoisoquinoline 1532-97-4
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-24