2,6-Dibromo-4-(trifluoromethoxy)aniline

Uses

Product Name: 2,6-Dibromo-4-(trifluoromethoxy)aniline
CAS No.: 88149-49-9
Chemical Name: 2,6-Dibromo-4-(trifluoromethoxy)aniline
Synonyms: Riluzole Impurity 2;BroMo Riluzole IMpurity;DBTFMA IMPURITY RLZ52-100;Riluzole Dibromo Impurity;3,5-Dibromo-4-Aminotrifluoromethoxy;6-DibroMo-4-(trifluoroMethoxy)aniline;2,6-Dibromo-4-Trifluromethoxy-Aniline;2,6-dibromo-4-(Trifluomethoxy) Aniline;2-Nitro-4-Bromotrifluoromethoxybenzene;3,5-Dibromo-4-(trifluoromethoxy)aniline
CBNumber: CB7777385
Molecular Formula: C7H4Br2F3NO
Formula Weight: 334.92
MOL File: 88149-49-9.mol

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2,6-Dibromo-4-(trifluoromethoxy)aniline Property

Melting point:: 70-74 °C(lit.)
Boiling point:: 65/0.1mm
Density: 2.036±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: -0.38±0.10(Predicted)
color: White to Off-White
InChI: InChI=1S/C7H4Br2F3NO/c8-4-1-3(14-7(10,11)12)2-5(9)6(4)13/h1-2H,13H2
InChIKey: JBSWOEGXMADXOU-UHFFFAOYSA-N
SMILES: C1(N)=C(Br)C=C(OC(F)(F)F)C=C1Br
CAS DataBase Reference: 88149-49-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-60-37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29222990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D3038
Product name: 2,6-Dibromo-4-(trifluoromethoxy)aniline
Purity: >98.0%(GC)
Packaging: 5g
Price: $44
Updated: 2025/07/31

TCI Chemical

Product number: D3038
Product name: 2,6-Dibromo-4-(trifluoromethoxy)aniline
Purity: >98.0%(GC)
Packaging: 25g
Price: $140
Updated: 2025/07/31

TRC

Product number: D426200
Product name: 2,6-Dibromo-4-(trifluoromethoxy)benzenamine
Packaging: 50g
Price: $340
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD39004
Product name: 2,6-Dibromo-4-(trifluoromethoxy)aniline
Packaging: 500g
Price: $450
Updated: 2021/12/16

AK Scientific

Product number: F208
Product name: 2,6-Dibromo-4-(trifluoromethoxy)aniline
Packaging: 500g
Price: $200
Updated: 2021/12/16

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2,6-Dibromo-4-(trifluoromethoxy)aniline Chemical Properties,Usage,Production

Uses

2,6-Dibromo-4-(trifluoromethoxy)benzenamine is used in the synthesis of novel pyridylpyrazole acid derivatives in the preparation of agricultural insecticides.

Chemical Properties

Light pink powder

Uses

2,6-Dibromo-4-(trifluoromethoxy)benzenamine is used in the synthesis of novel pyridylpyrazole acid derivatives in the preparation of agricultural insecticides.

Synthesis

461-82-5

88149-49-9

The general procedure for the synthesis of 2,6-dibromo-4-(trifluoromethoxy)aniline from p-trifluoromethoxyaniline was as follows: first, 156 g of the crystallized mother liquor containing sodium sulfate was filtered into a 250 mL four-necked flask and the stirring apparatus was started. Subsequently, 17.5 g (0.175 mol) of the reagent was slowly added dropwise, followed by 36.5 g of sodium bromide (0.354 mol) and 30 g (99% purity, 0.168 mol) of 4-trifluoromethoxyaniline. The temperature of the reaction system was adjusted to above 30 °C and the dropwise addition of 38 g of 35% hydrogen peroxide solution was started. During the dropwise addition, if the temperature increased to 50 °C, the reaction temperature was controlled between 50 and 55 °C by adjusting the dropwise acceleration of the coolant. After the dropwise addition was completed, the reaction temperature was maintained to drop and the reaction was continued to be held for 3 hours. Upon completion of the reaction, the system was cooled to about 30°C and the filtration operation was carried out. The resulting filter cake was dried to obtain 55.8 g of white crystals of 2,6-dibromo-4-trifluoromethoxyaniline, which was analyzed by high performance liquid chromatography (HPLC) with a purity of 99.6% and a yield of 99.2%.

References

[1] Patent: CN106631839, 2017, A. Location in patent: Paragraph 0022-0033
[2] Organic Letters, 2011, vol. 13, # 20, p. 5636 - 5639

2,6-Dibromo-4-(trifluoromethoxy)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

THIFLUZAMIDE

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View Lastest Price from 2,6-Dibromo-4-(trifluoromethoxy)aniline manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2,6-Dibromo-4-(trifluoromethoxy)aniline 88149-49-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

Hebei Yanxi Chemical Co., Ltd.

Product: 2,6-Dibromo-4-(trifluoromethoxy)aniline 88149-49-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: Min.99.5%GC
Supply Ability: 20tons
Release date: 2023-09-14

Shaanxi Dideu Medichem Co. Ltd

Product: 2,6-Dibromo-4-(trifluoromethoxy)aniline 88149-49-9
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%
Supply Ability: 2000tons
Release date: 2020-01-16

88149-49-9, 2,6-Dibromo-4-(trifluoromethoxy)anilineRelated Search:

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2,6-Dibromo-4-(trifluoromethoxy)aniline&gt

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2-Nitro-4-Bromotrifluoromethoxybenzene

88149-49-9

C7H4NOBr2F3

C6H2Br2OCF3NH2

C7H4Br2F3NO

ARYL AMINE

Nitrogen Compounds

Organic Building Blocks

C7

Building Blocks

Amines

amine| alkyl bromide