ChemicalBook > CAS DataBase List > Pomalidomide-PEG4-azide
Pomalidomide-PEG4-azide
- Product Name
- Pomalidomide-PEG4-azide
- CAS No.
- 2271036-47-4
- Chemical Name
- Pomalidomide-PEG4-azide
- Synonyms
- Pomalidomide-PEG?-Azide;Pomalidomide-PEG4-azide;Pomalidomide-NH-?PEG4-?azide;4-((14-azido-3,6,9,12-tetraoxatetradecyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;1H-Isoindole-1,3(2H)-dione, 4-[(14-azido-3,6,9,12-tetraoxatetradec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)-;14-Azido-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12-tetraoxatetradecanamide, Crosslinker-E3 ligase ligand conjugate, Pomalidomide conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
- CBNumber
- CB78054794
- Molecular Formula
- C23H30N6O8
- Formula Weight
- 518.53
- MOL File
- 2271036-47-4.mol
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Pomalidomide-PEG4-azide Property
- storage temp.
- 2-8°C
- form
- Oil
- color
- Light yellow to green yellow
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Pomalidomide-PEG4-azide Chemical Properties,Usage,Production
Uses
Protein degrader builiding block Pomalidomide-PEG4-Azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
storage
Store at -20°C
Pomalidomide-PEG4-azide Preparation Products And Raw materials
Raw materials
Preparation Products
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Pomalidomide-PEG4-azide Suppliers
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View Lastest Price from Pomalidomide-PEG4-azide manufacturers
Xian confluore Biological Technology Co., Ltd.
- Product
- Pomalidomide-NH-PEG4-azide 2271036-47-4
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- >95.00%
- Supply Ability
- 100mg
- Release date
- 2024-04-01
2271036-47-4, Pomalidomide-PEG4-azideRelated Search:
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E3 Ligase Ligand-Linker Conjugates 22
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