CIVENTICHEM CV-4057
- Product Name
- CIVENTICHEM CV-4057
- CAS No.
- 248281-84-7
- Chemical Name
- CIVENTICHEM CV-4057
- Synonyms
- LAQ;CS-82;ABR 215062;ABR-215062;Lanquinimod;CIVENTICHEM;oro-N-ethyL;-2-oxo-N-phenyL;Laquinimod, >=98%;ine-3-carboxamide
- CBNumber
- CB7836628
- Molecular Formula
- C19H17ClN2O3
- Formula Weight
- 356.8
- MOL File
- 248281-84-7.mol
CIVENTICHEM CV-4057 Property
- Melting point:
- 201 °C (decomp)
- Boiling point:
- 484.8±45.0 °C(Predicted)
- Density
- 1.395±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in DMSO (>25 mg/ml)
- form
- solid
- pka
- 4.50±1.00(Predicted)
- color
- Off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- SML2504
- Product name
- Laquinimod
- Purity
- ≥98% (HPLC)
- Packaging
- 10MG
- Price
- $40.8
- Updated
- 2024/03/01
- Product number
- SML2504
- Product name
- Laquinimod
- Purity
- ≥98% (HPLC)
- Packaging
- 50MG
- Price
- $386
- Updated
- 2024/03/01
- Product number
- CVT00095
- Product name
- 5-Chloro-N-Et-4-hydroxy-1-methyl-2-oxo-N-Ph-1,2-dihydroquinoline-3-carboxamide
- Packaging
- 1g
- Price
- $724
- Updated
- 2024/03/01
- Product number
- 24187
- Product name
- Laquinimod
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 24187
- Product name
- Laquinimod
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $172
- Updated
- 2024/03/01
CIVENTICHEM CV-4057 Chemical Properties,Usage,Production
Description
Laquinimod (248281-84-7) is an immunomodulator1 that inhibits inflammation2 and autoimmunity3,4 via activation of the aryl hydrocarbon receptor (AhR)5. It has been investigated as a treatment for multiple sclerosis6 and has shown efficacy in Huntington’s disease models7,8.
Definition
ChEBI: Laquinimod is an aromatic amide.
in vitro
abr-215062 was shown to completely inhibit the development of murine acute experimental autoimmune encephalomyelitis (eae) [1].
in vivo
abr-215062 dose-dependently inhibited disease and showed better disease inhibitory effects as compared to roquinimex (linomide). furthermore, abr-215062 inhibited the inflammation of both cd4+ t cells and macrophages into central nervous tissues [2].
References
J?nsson et al. (2004), Synthesis and Biological Evaluation of New 1,2-Dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for Treatment of Autoimmune Disorders: Structure-Activity Relationship; Med. Chem. 47 2075 Rothhammer et al. (2021); Aryl Hydrocarbon Receptor Activation in Astrocytes by Laquinimod Ameliorates Autoimmune Inflammation in the CNS, Neurol. Neuroimmunol. Neuroinflamm., 8 e946 Pitarokoili et al. (2014), Laquinimod exerts strong clinical and immunomodulatory effects in Lewis rat experimental autoimmune neuritis; Neuroimmunol., 274 38 Ott et al. (2019), Laquinimod, a prototypic quinoline-3-carboxamide and aryl hydrocarbon receptor agonist, utilizes CD155-mediated natural killer/dendritic cell interaction to suppress CNS autoimmunity; Neuroinflammation, 16 49 Kaye et al. (2016), Laquinimod arrests experimental autoimmune encephalitis by activating the aryl hydrocarbon receptor; Natl. Acad. Sci. USA., 113 E6145 Th?ne and Linker (2016), Laquinimod in the treatment of multiple sclerosis: a review of the data so far; Drug Des. Devel. Ther., 10 1111 Dobson et al. (2016), Laquinimod dampens hyperactive cytokine production in Huntington’s disease patient myeloid cells; Neurochem., 137 782 Garcia-Miralles et al. (2016), Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease; Rep., 6 31652
CIVENTICHEM CV-4057 Preparation Products And Raw materials
Raw materials
Preparation Products
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