ChemicalBook > CAS DataBase List > 5-Amino-2-bromopyridine

5-Amino-2-bromopyridine

Product Name
5-Amino-2-bromopyridine
CAS No.
13534-97-9
Chemical Name
5-Amino-2-bromopyridine
Synonyms
6-BROMOPYRIDIN-3-AMINE;5-BROMO-PYRIDIN-2-YLAMINE;2-Bromo-5;AKOS BBS-00004444;TIMTEC-BB SBB003823;TIMTEC-BB SBB005540;LABOTEST-BB LT00129606;2-Bromo-5-aminoyridine;6-BROMO-3-PYRIDINAMINE;5-amine-2-bromopyridin
CBNumber
CB7853072
Molecular Formula
C5H5BrN2
Formula Weight
173.01
MOL File
13534-97-9.mol
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5-Amino-2-bromopyridine Property

Melting point:
75 °C
Boiling point:
180 °C
Density 
1.6065 (rough estimate)
refractive index 
1.5182 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
1.87±0.10(Predicted)
form 
Powder
color 
Beige to brown-black
BRN 
109102
InChI
InChI=1S/C5H5BrN2/c6-5-2-1-4(7)3-8-5/h1-3H,7H2
InChIKey
XTHKRYHULUJQHN-UHFFFAOYSA-N
SMILES
C1=NC(Br)=CC=C1N
CAS DataBase Reference
13534-97-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
F 
10
HazardClass 
IRRITANT
PackingGroup 
III
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
552844
Product name
3-Amino-6-bromopyridine
Purity
97%
Packaging
5g
Price
$37.5
Updated
2025/07/31
Sigma-Aldrich
Product number
552844
Product name
3-Amino-6-bromopyridine
Purity
97%
Packaging
1g
Price
$48
Updated
2023/06/20
TCI Chemical
Product number
A1890
Product name
5-Amino-2-bromopyridine
Purity
>97.0%(GC)
Packaging
1g
Price
$36
Updated
2025/07/31
TCI Chemical
Product number
A1890
Product name
5-Amino-2-bromopyridine
Purity
>97.0%(GC)
Packaging
5g
Price
$108
Updated
2025/07/31
TRC
Product number
A601875
Product name
5-Amino-2-bromopyridine
Packaging
25g
Price
$455
Updated
2021/12/16
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5-Amino-2-bromopyridine Chemical Properties,Usage,Production

Chemical Properties

Light yellow needles

Uses

3-Amino-6-bromopyridine may undergo polymerization via Buchwald–Hartwig amination in the presence of sodium tert-butoxide and XPhos(2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl) ligand yielding para-linked and meta-linked polyaminopyridines.

General Description

3-Amino-6-bromopyridine can be synthesized via bromination of 3-aminopyridine using N-bromosuccinimide in acetonitrile.

Synthesis

4487-59-6

13534-97-9

General procedure for the synthesis of 5-amino-2-bromopyridine from 2-bromo-5-nitropyridine: To a solution of 2-bromo-5-nitropyridine (2.03 g, 10 mmol) in ethanol (48 mL) was added sequentially iron powder (2.8 g, 50 mmol), concentrated hydrochloric acid (1.9 mL) and water (9.1 mL). The reaction mixture was stirred under reflux conditions for 5 hours. After completion of the reaction, it was cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure, the pH was adjusted to 7-8 with base and subsequently extracted with dichloromethane (DCM). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the reddish brown solid product 5-amino-2-bromopyridine (1.58 g, 91.3% yield).

References

[1] Bulletin des Societes Chimiques Belges, 1988, vol. 97, # 1, p. 51 - 54
[2] Green Chemistry, 2018, vol. 20, # 1, p. 130 - 135
[3] Journal of Organic Chemistry, 2011, vol. 76, # 23, p. 9841 - 9844
[4] Patent: EP2886540, 2015, A1. Location in patent: Paragraph 0143; 0144
[5] Patent: US2014/93505, 2014, A1. Location in patent: Page/Page column

5-Amino-2-bromopyridine Preparation Products And Raw materials

Raw materials

Stannous chloride dihydrate Aluminium-nickel PHOSPHORUS PENTABROMIDE Phosphorus oxybromide 2-Bromo-5-nitropyridine Hydrochloric acid Iron Phosphorus tribromide 2-Hydroxy-5-nitropyridine

Preparation Products

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5-Amino-2-bromopyridine Suppliers

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View Lastest Price from 5-Amino-2-bromopyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
5-Amino-2-bromopyridine 13534-97-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-06-03
Henan Aochuang Chemical Co.,Ltd.
Product
5-Amino-2-bromopyridine 13534-97-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-12
Henan Fengda Chemical Co., Ltd
Product
5-Amino-2-bromopyridine 13534-97-9
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08

13534-97-9, 5-Amino-2-bromopyridineRelated Search:

2-Bromo-5-chloropyridine ALTRENOGEST 2,6-Diaminopyridine 4-Dimethylaminopyridine 3-Aminopyridine 4-Aminopyridine 2-Bromo-5-fluoropyridine 6-Aminocaproic acid 2-Bromo-5-nitropyridine 2-Bromopyridine Glycine 2-Aminopyridine 2-Aminophenol Tris(hydroxymethyl)aminomethane 2-BROMO-5-METHOXYPYRIDINE 2-Bromo-5-methylpyridine 2-Bromo-6-(trifluoromethyl)pyridine 2-Bromo-6-methylpyridine

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  • 2-BroMo-5-pyridinaMine
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  • 3-Amino-6-bromopyridine,98%
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  • Building Blocks
  • Bromopyridines
  • Halopyridines
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyrimidines
  • Pyridines
  • Building Blocks
  • C5
  • C5 to C6
  • Chemical Synthesis
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Amino-pyridine series
  • C5Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Chemical Amines
  • Bromopyridines
  • Halopyridines
  • Aromatics
  • Boronic Acid
  • pharmacetical
  • Pyridine series
  • Amines
  • blocks