ChemicalBook > CAS DataBase List > 1-BENZHYDRYLPIPERAZINE

1-BENZHYDRYLPIPERAZINE

Product Name
1-BENZHYDRYLPIPERAZINE
CAS No.
841-77-0
Chemical Name
1-BENZHYDRYLPIPERAZINE
Synonyms
Diphenylmethylpiperazine;1-(DIPHENYLMETHYL)PIPERAZINE;NSC 35536;norcyclizine;AKOS NCG1-0108;AKOS BBS-00003601;TIMTEC-BB SBB003136;BENZHYDRYLPIPERAZINE;Benzhydrol piperzine;1-BENZHYDRYLPIPERAZINE
CBNumber
CB8117067
Molecular Formula
C17H20N2
Formula Weight
252.35
MOL File
841-77-0.mol
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1-BENZHYDRYLPIPERAZINE Property

Melting point:
90-93 °C
Boiling point:
185°C/2mmHg(lit.)
Density 
1.0546 (rough estimate)
vapor pressure 
0.001Pa at 20℃
refractive index 
1.5794 (estimate)
Flash point:
115 °C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Methanol (Slightly)
pka
9.05±0.10(Predicted)
form 
Crystalline Powder
color 
White to light yellow
Water Solubility 
0.45 g/L (20 ºC)
Sensitive 
Air Sensitive
BRN 
222773
LogP
0.6 at 20℃
CAS DataBase Reference
841-77-0(CAS DataBase Reference)
NIST Chemistry Reference
Benzhydryl piperazine(841-77-0)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22
Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
TL6465000
F 
34
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
B3760
Product name
1-Benzhydrylpiperazine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$84
Updated
2024/03/01
TCI Chemical
Product number
B3760
Product name
1-Benzhydrylpiperazine
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$251
Updated
2024/03/01
Alfa Aesar
Product number
L11530
Product name
1-Benzhydrylpiperazine, 97%
Packaging
25g
Price
$39.7
Updated
2024/03/01
Alfa Aesar
Product number
L11530
Product name
1-Benzhydrylpiperazine, 97%
Packaging
100g
Price
$85.6
Updated
2024/03/01
TRC
Product number
B196950
Product name
1-Benzhydrylpiperazine
Packaging
50g
Price
$95
Updated
2021/12/16
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1-BENZHYDRYLPIPERAZINE Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystalline powder

Uses

Cinnarizine (C465300) impurity.

Uses

1-(Diphenylmethyl)piperazine [N-(Diphenylmethyl)piperazine] may be used for the synthesis of 2-nitro-3,4,4-trichloro-1-(propylthio)-1-[4-(diphenylmethyl)piperazin-1-yl]-1,3-butadiene and 2-nitro-3,4,4-trichloro-1-(octadecylthio)-1-[4-(diphenylmethyl)piperazin-1-yl]-1,3-butadiene.

Uses

1-Benzhydrylpiperazine is an intermediate used in drug synthesis

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 1098, 1955 DOI: 10.1021/ja01610a006

General Description

1-(Diphenylmethyl)piperazine is an intermediate during drug synthesis. It has been reported to be formed during the oxidative metabolism of cinnarizine (CZ) [1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine] in rat liver microsomes. It reacts with quinone in acetonitrile, followed by oxidation with an alkaline potassium ferricyanide, to afford 4-amino-3,6-di(tert-butyl)-o-benzoquinones.

Flammability and Explosibility

Not classified

1-BENZHYDRYLPIPERAZINE Preparation Products And Raw materials

Raw materials

Piperazine Dilute hydrochloric acid Benzhydrol Chlorodiphenylmethane

Preparation Products

Meclozine Oxatomide Stugeron
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1-BENZHYDRYLPIPERAZINE Suppliers

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View Lastest Price from 1-BENZHYDRYLPIPERAZINE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
1-Benzhydrylpiperazine 841-77-0
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-03
Xuchang Hengsheng Pharmaceutical Co., Ltd
Product
1-(diphenylmethyl)-piperazin 841-77-0
Price
US $0.00/Kg
Min. Order
1Kg
Purity
≥99.0%
Supply Ability
10 Tons
Release date
2024-08-07
Career Henan Chemical Co
Product
1-BENZHYDRYLPIPERAZINE 841-77-0
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2019-05-24

841-77-0, 1-BENZHYDRYLPIPERAZINERelated Search:

1-(DiphenylMethyl)-4-[(1RS,3E)-4-phenyl-1-[(E)-2-phenylethenyl)-3-buten-1-yl]piperazine IMp. E (EP): 1,4-Bis(diphenylMethyl)piperazine IMp. C (EP): (4-(DiphenylMethyl)-1,1-bis[(E)-3-phenylprop-2-enyl]piperaziniuM Chloride (Z)-Cinnarizine Chlorodiphenylphosphine CHLORCYCLIZINE Cyclizine 1-BENZHYDRYLPIPERAZINE Hydroxyzine dihydrochloride CHLORCYCLIZINE HYDROCHLORIDE Flunarizine dihydrochloride Meclizine dihydrochloride 4,4'-Difluorobenzhydrylpiperazine 1-(4-Chlorobenzhydryl)piperazine Stugeron 1-(4,4'-DICHLOROBENZHYDRYL)PIPERAZINE Buterizine Piperazine

  • 1-(diphenylmethyl)-piperazin
  • 1-(Diphenylmethyl)piperazine,97%
  • AKOS BBS-00003601
  • AKOS NCG1-0108
  • TIMTEC-BB SBB003136
  • N-BENZHYDRYLPIPERAZINE
  • N-BENZYLHYDRYLPIPERAZINE
  • 1-(DIPHENYLMETHYL)PIPERAZINE
  • 1-BENZHYDRYLPIPERAZINE
  • 1-BENZYHYDRYLPIPERAZINE
  • BENZHYDRYLPIPERAZINE
  • LABOTEST-BB LT00454383
  • 1-Benzhydrylpiperazine 97%
  • 1-Benzhydrylpiperazine ,99%
  • Cinnarizine Impurity 1(Cinnarizine EP Impurity A)
  • Piperazine, 1-(diphenylmethyl)-
  • 4-(DiphenylMethyl)piperazine
  • NSC 35536
  • Cinnarizine EP IMpurity A
  • 1-(DiphenylMethyl)piperazine SynonyMs Benzhydrylpiperazine
  • 1-(Diphenylmethyl)piperazine >=98.0% (NT)
  • 1-(Diphenylmethyl)piperazineone
  • 4-benzhydrylpiperazine
  • Diphenylmethylpiperazine
  • N-(Diphenylmethyl)piperazine
  • norcyclizine
  • Cetirizine SM impurity 1 HCl
  • 1-Benzhydrylpiperazine &gt
  • 1-BENZHYDRYLPIPERAZINE ISO 9001：2015 REACH
  • Cinnarizine EP Impurity A 841-77-0
  • Nor-cyclizineQ: What is Nor-cyclizine Q: What is the CAS Number of Nor-cyclizine Q: What is the storage condition of Nor-cyclizine Q: What are the applications of Nor-cyclizine
  • 1-BENZHYDRYLPIPERAZINEidazol-2-one
  • Benzhydrol piperzine
  • 841-77-0
  • C20H17N2
  • C17H20N2
  • AMINE
  • Building Blocks
  • Piperazines
  • Heterocyclic Building Blocks
  • Building Blocks
  • C16 to C29
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Piperazines
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Piperaizine
  • Piperazine derivates
  • Aromatics