Etonogestrel

Product Name: Etonogestrel
CAS No.: 54048-10-1
Chemical Name: Etonogestrel
Synonyms: Nexplanon;Implanon;org3236;CS-1364;Etonoestrel;ETONOGESTREL;3-oxodesogestrel;3-KETO DESOGESTREL;Etonogestrel Solution;Deoxyprene impurity D
CBNumber: CB8146610
Molecular Formula: C22H28O2
Formula Weight: 324.46
MOL File: 54048-10-1.mol

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Etonogestrel Property

Melting point:: 182-184°C
Boiling point:: 473.1±45.0 °C(Predicted)
alpha: D +87.6°
Density: 1.13±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: >5mg/mL
pka: 13.04±0.40(Predicted)
form: powder
color: white to beige
optical activity: [α]/D +80 to +95°, c = 1 (CHCl3)
InChI: InChI=1/C22H28O2/c1-4-21-13-14(3)20-17-9-7-16(23)12-15(17)6-8-18(20)19(21)10-11-22(21,24)5-2/h2,12,17-20,24H,3-4,6-11,13H2,1H3/t17-,18-,19-,20+,21-,22-/s3
InChIKey: GCKFUYQCUCGESZ-BPIQYHPVSA-N
SMILES: C([C@]12CC(=C)[C@]3([H])[C@@]4([H])CCC(=O)C=C4CC[C@@]3([H])[C@]1([H])CC[C@@]2(O)C#C)C |&1:1,5,7,17,19,23,r|
CAS DataBase Reference: 54048-10-1(CAS DataBase Reference)

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Safety

Risk Statements: 60-40
WGK Germany: 3
RTECS: JF8290000
HS Code: 2937230000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H351Suspected of causing cancer

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0356
Product name: Etonogestrel
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0356
Product name: Etonogestrel
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $463
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR2453
Product name: Etonogestrel
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 200MG
Price: $534
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1173268
Product name: Desogestrel Related Compound C
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25MG
Price: $1370
Updated: 2022/05/15

Cayman Chemical

Product number: 21062
Product name: Etonogestrel
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

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Etonogestrel Chemical Properties,Usage,Production

Description

Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001.

Chemical Properties

White Solid

Uses

A biologically active metabolite of Desogestrel.

Definition

ChEBI: Etonogestrel is a 17beta-hydroxy steroid, a 3-oxo-Delta(4) steroid and a terminal acetylenic compound. It has a role as a contraceptive drug, a progestin and a female contraceptive drug.

brand name

Implanon (Organon).

General Description

Etonogestrel, 17α-13-ethyl-17hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one,3-ketodesogestrel, is the active metabolite of desogestrel. It isthe progestin component in a newer implantable contraceptive(Implanon) and in the vaginal contraceptive ring (NuvaRing).

Biochem/physiol Actions

Etonogestrel is a lipophilic molecule. Pharmacokinetics studies reveal that etonogestrel is bound to protein albumin in the blood. This remains independent of both endogenous and exogenous concentration of estradiol.

Mode of action

Etonogestrel binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor mediated gene expression. As a result of the negative feedback mechanism, luteinizing hormone (LH) release is inhibited, which leads to an inhibition of ovulation and an alteration in the cervical mucus and endometrium.

Etonogestrel Preparation Products And Raw materials

Raw materials

Preparation Products

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Etonogestrel Suppliers

Canada 4 China 160 Europe 2 France 1 Germany 1 Hungary 2 India 6 Italy 1 The Netherlands 1 United Kingdom 5 United States 21 Global 204

Novachemistry

Tel: 44-20819178-90 02081917890
Fax: (0)2080432064
Email: info@novachemistry.com
Country: United Kingdom
ProdList: 4381
Advantage: 58

Whyte Chemicals

Tel: --
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Email: sales@whytechemicals.co.uk
Country: United Kingdom
ProdList: 3748
Advantage: 50

Leancare Ltd.

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Email: enquiry@leancare.co.uk
Country: United Kingdom
ProdList: 6446
Advantage: 42

CARBONE SCIENTIFIC CO.,LTD

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Email: sales@carbonesci.com
Country: United Kingdom
ProdList: 6666
Advantage: 30

Eurolabs Limited

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Country: United Kingdom
ProdList: 6309
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View Lastest Price from Etonogestrel manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: Etonogestrel 54048-10-1
Price: US $1000.00-800.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-16

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Etonogestrel 54048-10-1
Price: US $1.00/g
Min. Order: 1g
Purity: ≥99%
Supply Ability: 10kg/month
Release date: 2021-06-10

Shaanxi Dideu Medichem Co. Ltd

Product: Etonogestrel 54048-10-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

54048-10-1, EtonogestrelRelated Search:

Gestrinone Trinexapac-ethyl Ethyl propiolate Ethyl acetate Altrenogest Desogestrel Gestodene CHLOROPHOSPHONAZO III Ethylparaben Ethyl acrylate Ethyl cyanoacetate Ethanol ISOXADIFEN-ETHYL Eprinomectin Ectoine Brexpiprazole Levonorgestrel Norgestrel

Desogestrel Related CoMpound C

13-ethyl-17-ethynyl-17-hydroxy-11-methylidene-2,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-one

3-KETO DESOGESTREL

ETONOGESTREL

(17alpha)-13-ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one

3-Ketodesogestrel,3-Oxodesogestrel,Org-3236,Implanon

(17R)-13-Ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one

Desogestrel Related Compound C (25 mg) (3-Keto-desogestrel)

Etonoestrel

(17α)-13-Ethyl-17-hydroxy-11-Methylene-18,19-dinorpregn-4-en-20-yn-3-one

(17a)-13-Ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one

Implanon

Deoxypregnancy impurity D

(17-alpha)-13-ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-on

13-ethyl-11-methylene-18,19-dinor-17-alpha-pregn-4-en-20-yn-3-one

17-ethinyl-17-beta-hydroxy-18-methyl-11-methylene-4-estren-3-one

19-dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-11-methylene-1(17-alpha

3-oxodesogestrel

org3236

Etonogestrel-d6（Desogestrel EP Impurity D-d6）

Desogestrel EP Impurity D-d6

IMPLANON;NEXPLANON;3-OXODESOGESTREL;3-KETO-DESOGESTREL

Nexplanon

CS-1364

Desogestrel Impurity 4(Desogestrel EP Impurity D)

3-Ketodesogestrel (Etonogestrel)

Etonogestrel Solution

desogestrel impurity D

Deoxyprene impurity D

18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-, (17α)-

Etonogestrel USP/EP/BP

ETONOGESTREL 54048-10-1

Etonogestrel D6Q: What is Etonogestrel D6 Q: What is the CAS Number of Etonogestrel D6 Q: What is the storage condition of Etonogestrel D6

Etonogestrel D7Q: What is Etonogestrel D7 Q: What is the CAS Number of Etonogestrel D7 Q: What is the storage condition of Etonogestrel D7

EtonogestrelQ: What is Etonogestrel Q: What is the CAS Number of Etonogestrel Q: What is the storage condition of Etonogestrel Q: What are the applications of Etonogestrel

Desogestrel Related Compound C (3-Ketodesogestrel) (1173268)

Etonogestrel (1268783)

11-Dihydrocarbamazepine

Desogestrel USP Related Compound C

Desogestrel Related Compound C (3-Ketodesogestrel)

Etonogestrel (Desogestrel EP Impurity D, Desogestrel USP Related Compound C, 3-Ketodesogestrel)

Desogestrel Related Compound C (25 mg) (13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol-3-one)

18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-, (17α)-

54048-10-1

54058-10-1

C22H28O2

API

Inhibitors

Hormone Drugs

Various Metabolites and Impurities

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Steroids