ChemicalBook > CAS DataBase List > Ethyl 2-amino-1,3-thiazole-4-carboxylate

Ethyl 2-amino-1,3-thiazole-4-carboxylate

Product Name
Ethyl 2-amino-1,3-thiazole-4-carboxylate
CAS No.
5398-36-7
Chemical Name
Ethyl 2-amino-1,3-thiazole-4-carboxylate
Synonyms
ETHYL 2-AMINOTHIAZOLE-4-CARBOXYLATE;2-aminothiazole-4-carboxylate;ETHYL-2-AMINO-1,3-THIOZOLE-4-CARBOXYLATE;2-AMINO-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;AKOS BB-9218;TOSLAB 14869;BUTTPARK 33\04-57;TIMTEC-BB SBB000178;Ethyl 2-amino-1,3-th;AclatoniumIntermediate
CBNumber
CB8254719
Molecular Formula
C6H8N2O2S
Formula Weight
172.2
MOL File
5398-36-7.mol
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Ethyl 2-amino-1,3-thiazole-4-carboxylate Property

Melting point:
177 °C
Boiling point:
308.0±15.0 °C(Predicted)
Density 
1.336±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
2.60±0.10(Predicted)
color 
Pale Beige
λmax
284nm(MeOH)(lit.)
InChI
InChI=1S/C6H8N2O2S/c1-2-10-5(9)4-3-11-6(7)8-4/h3H,2H2,1H3,(H2,7,8)
InChIKey
XHFUVBWCMLLKOZ-UHFFFAOYSA-N
SMILES
S1C=C(C(OCC)=O)N=C1N
CAS DataBase Reference
5398-36-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
24/25-36/37/39-26-22
WGK Germany 
nwg
HazardClass 
IRRITANT
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
705152
Product name
Ethyl 2-aminothiazole-4-carboxylate
Purity
96%
Packaging
1g
Price
$43.2
Updated
2023/06/20
Sigma-Aldrich
Product number
705152
Product name
Ethyl 2-aminothiazole-4-carboxylate
Purity
96%
Packaging
5g
Price
$91.4
Updated
2023/06/20
TCI Chemical
Product number
E1215
Product name
Ethyl 2-Aminothiazole-4-carboxylate
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$41
Updated
2025/07/31
TCI Chemical
Product number
E1215
Product name
Ethyl 2-Aminothiazole-4-carboxylate
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$122
Updated
2025/07/31
TRC
Product number
E678465
Product name
Ethyl2-Amino-1,3-thiazole-4-carboxylate
Packaging
5g
Price
$65
Updated
2021/12/16
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Ethyl 2-amino-1,3-thiazole-4-carboxylate Chemical Properties,Usage,Production

Chemical Properties

white crystal powde

Uses

Ethyl 2-Amino-1,3-thiazole-4-carboxylate is a chemical reagent used in the preparation fo SAR thiazolamino arylaminopyrimidines as anaplastic lymphoma kinase inhibitors. As well as in the synthesis of 4-bicyclick piperadine derivatives as potent stearoyl-CoA desaturase (SCD1) inhibitors in the treatment of cancer.

Synthesis

70-23-5

17356-08-0

5398-36-7

GENERAL METHOD: A mixture of thiourea (1.2 mmol) and ethyl 3-bromopyruvate (1 mmol) in ethanol (2 mL) was reacted with stirring at 70°C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature and subsequently poured into ice water. The precipitate precipitated was collected by filtration and dried to give the target product ethyl 2-aminothiazole-4-carboxylate. The products were characterized as follows: 6a (99% yield), white solid, melting point 150-152 °C (literature value 149-150 °C); 6b (100% yield), white solid, melting point 162-165 °C (literature value 163-164 °C); 6c (0.236 g, 93% yield), white solid, melting point 179-181 °C (literature value 180- 181°C); 6d (98% yield), white solid, melting point 203.6-204.2°C (literature value 204.0-204.5°C); 6e (94% yield), bright yellow solid, melting point 287-288°C (literature value 285-286°C); 6f (100% yield), white solid, melting point 172-174°C (literature value 172°C).

References

[1] Arkivoc, 2018, vol. 2018, # 7, p. 110 - 118
[2] Patent: CN104016944, 2016, B. Location in patent: Paragraph 0014-0015; 0040-0041
[3] Organic and Biomolecular Chemistry, 2012, vol. 10, # 30, p. 5764 - 5768
[4] Letters in Drug Design and Discovery, 2018, vol. 16, # 2, p. 160 - 173
[5] Patent: WO2007/146066, 2007, A2. Location in patent: Page/Page column 151-152

Ethyl 2-amino-1,3-thiazole-4-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 2-amino-1,3-thiazole-4-carboxylate Suppliers

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View Lastest Price from Ethyl 2-amino-1,3-thiazole-4-carboxylate manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
Ethyl 2-amino-1,3-thiazole-4-carboxylate 5398-36-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-10
Suzhou Nordica Biopharma CO.,LTD
Product
ethyl 2-aminothiazole-4-carboxylate 5398-36-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
5 tons
Release date
2024-11-15
Henan Fengda Chemical Co., Ltd
Product
Ethyl 2-amino-1,3-thiazole-4-carboxylate 5398-36-7
Price
US $6.00-0.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-24

5398-36-7, Ethyl 2-amino-1,3-thiazole-4-carboxylateRelated Search:

Ethyl cyanoacetate Ethyl formate 2-Amino-4-methylthiazole RESMETHRIN Urethane Ethylparaben Ethanol Benzocaine 2-Aminothiazole Trinexapac-ethyl ISOXADIFEN-ETHYL 4-Thiazolecarboxylic acid Ethyl acetate Ethyl acrylate 2-(2-Aminothiazol-4-yl)glyoxylic acid Ethyl propiolate Ethyl 2-aminothiazole-5-carboxylate ETHYL 2-AMINOTHIAZOLE-4-CARBOXYLATE

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  • AclatoniumIntermediate
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  • C6H8S2O2
  • amine| carboxylic ester
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  • 5398-36-7