Ethyl 2-amino-1,3-thiazole-4-carboxylate

Product Name: Ethyl 2-amino-1,3-thiazole-4-carboxylate
CAS No.: 5398-36-7
Chemical Name: Ethyl 2-amino-1,3-thiazole-4-carboxylate
Synonyms: ETHYL 2-AMINOTHIAZOLE-4-CARBOXYLATE;2-aminothiazole-4-carboxylate;ETHYL-2-AMINO-1,3-THIOZOLE-4-CARBOXYLATE;2-AMINO-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;AKOS BB-9218;TOSLAB 14869;BUTTPARK 33\04-57;TIMTEC-BB SBB000178;Ethyl 2-amino-1,3-th;AclatoniumIntermediate
CBNumber: CB8254719
Molecular Formula: C6H8N2O2S
Formula Weight: 172.2
MOL File: 5398-36-7.mol

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Ethyl 2-amino-1,3-thiazole-4-carboxylate Property

Melting point:: 177 °C
Boiling point:: 308.0±15.0 °C(Predicted)
Density: 1.336±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 2.60±0.10(Predicted)
color: Pale Beige
λmax: 284nm(MeOH)(lit.)
InChI: InChI=1S/C6H8N2O2S/c1-2-10-5(9)4-3-11-6(7)8-4/h3H,2H2,1H3,(H2,7,8)
InChIKey: XHFUVBWCMLLKOZ-UHFFFAOYSA-N
SMILES: S1C=C(C(OCC)=O)N=C1N
CAS DataBase Reference: 5398-36-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 24/25-36/37/39-26-22
WGK Germany: nwg
HazardClass: IRRITANT
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 705152
Product name: Ethyl 2-aminothiazole-4-carboxylate
Purity: 96%
Packaging: 1g
Price: $43.2
Updated: 2023/06/20

Sigma-Aldrich

Product number: 705152
Product name: Ethyl 2-aminothiazole-4-carboxylate
Purity: 96%
Packaging: 5g
Price: $91.4
Updated: 2023/06/20

TCI Chemical

Product number: E1215
Product name: Ethyl 2-Aminothiazole-4-carboxylate
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: E1215
Product name: Ethyl 2-Aminothiazole-4-carboxylate
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $122
Updated: 2025/07/31

TRC

Product number: E678465
Product name: Ethyl2-Amino-1,3-thiazole-4-carboxylate
Packaging: 5g
Price: $65
Updated: 2021/12/16

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Ethyl 2-amino-1,3-thiazole-4-carboxylate Chemical Properties,Usage,Production

Chemical Properties

white crystal powde

Uses

Ethyl 2-Amino-1,3-thiazole-4-carboxylate is a chemical reagent used in the preparation fo SAR thiazolamino arylaminopyrimidines as anaplastic lymphoma kinase inhibitors. As well as in the synthesis of 4-bicyclick piperadine derivatives as potent stearoyl-CoA desaturase (SCD1) inhibitors in the treatment of cancer.

Synthesis

70-23-5

17356-08-0

5398-36-7

GENERAL METHOD: A mixture of thiourea (1.2 mmol) and ethyl 3-bromopyruvate (1 mmol) in ethanol (2 mL) was reacted with stirring at 70°C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature and subsequently poured into ice water. The precipitate precipitated was collected by filtration and dried to give the target product ethyl 2-aminothiazole-4-carboxylate. The products were characterized as follows: 6a (99% yield), white solid, melting point 150-152 °C (literature value 149-150 °C); 6b (100% yield), white solid, melting point 162-165 °C (literature value 163-164 °C); 6c (0.236 g, 93% yield), white solid, melting point 179-181 °C (literature value 180- 181°C); 6d (98% yield), white solid, melting point 203.6-204.2°C (literature value 204.0-204.5°C); 6e (94% yield), bright yellow solid, melting point 287-288°C (literature value 285-286°C); 6f (100% yield), white solid, melting point 172-174°C (literature value 172°C).

References

[1] Arkivoc, 2018, vol. 2018, # 7, p. 110 - 118
[2] Patent: CN104016944, 2016, B. Location in patent: Paragraph 0014-0015; 0040-0041
[3] Organic and Biomolecular Chemistry, 2012, vol. 10, # 30, p. 5764 - 5768
[4] Letters in Drug Design and Discovery, 2018, vol. 16, # 2, p. 160 - 173
[5] Patent: WO2007/146066, 2007, A2. Location in patent: Page/Page column 151-152

Ethyl 2-amino-1,3-thiazole-4-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 2-amino-1,3-thiazole-4-carboxylate Suppliers

Americas 1 Belgium 1 China 399 China Hong Kong 1 Europe 3 Germany 3 India 26 Japan 2 Slovakia 1 South Korea 1 Switzerland 1 Ukraine 3 United Kingdom 12 United States 45 Global 499

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View Lastest Price from Ethyl 2-amino-1,3-thiazole-4-carboxylate manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Ethyl 2-amino-1,3-thiazole-4-carboxylate 5398-36-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-10

Suzhou Nordica Biopharma CO.,LTD

Product: ethyl 2-aminothiazole-4-carboxylate 5398-36-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 5 tons
Release date: 2024-11-15

Henan Fengda Chemical Co., Ltd

Product: Ethyl 2-amino-1,3-thiazole-4-carboxylate 5398-36-7
Price: US $6.00-0.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-24

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C6H8S2O2

amine| carboxylic ester

Building Blocks/Intermediates

Pharmaceutical raw materials

pharmacetical

Esters

Thiazoles, Isothiazoles &Benzothiazoles

Amines

blocks

Carboxes

Thiazoles

Thiazoles, Isothiazoles & Benzothiazoles

API

Heterocycle intermediates

Amino Acids and Derivatives

Heterocycles

bc0001

5398-36-7