1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy

Product Name: 1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy
CAS No.: 145317-11-9
Chemical Name: 1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy
Synonyms: BIM X;BIM-X hydrochloride;Ro 31-8425 Ro 31-8425;Bisindoylmaleimide X HCl;BIM X;RO 31-8425RO 31-8425;Bisindoylmaleimide X hydrochloride ≥95%;Bisindoylmaleimide X (Ro 31-8425);BISINDOLYLMALEIMIDE X HYDROCHLORIDE (BIM-X HYDROCHLORIDE);Bisindolylmaleimide X hydrochloride (Ro 31-8425), PKC inhibitor;3-[8-(aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione
CBNumber: CB82667395
Molecular Formula: C26H25ClN4O2
Formula Weight: 460.96
MOL File: 145317-11-9.mol

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1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Soluble in DMSO (up to 10 mg/ml)
form: Red solid.
color: Red
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B3931
Product name: Bisindolylmaleimide X hydrochloride
Purity: ≥90%, solid
Packaging: 1MG
Price: $140
Updated: 2023/06/20

Sigma-Aldrich

Product number: B3931
Product name: Bisindolylmaleimide X hydrochloride
Purity: ≥90%, solid
Packaging: 5MG
Price: $539
Updated: 2023/06/20

Cayman Chemical

Product number: 17511
Product name: Bisindolylmaleimide X (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $60
Updated: 2024/03/01

Cayman Chemical

Product number: 17511
Product name: Bisindolylmaleimide X (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $201
Updated: 2024/03/01

TRC

Product number: B448525
Product name: BisindolylmaleimideXHydrochloride
Packaging: 5mg
Price: $165
Updated: 2021/12/16

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1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy Chemical Properties,Usage,Production

Description

Ro 31-8425 (145317-11-9) is a selective, reversible, ATP-competitive inhibitor of protein kinase C. Inhibits PKCα, β1, β2, γ and ε, IC50= 8, 8, 14,13 and 39 nM respectively.1? Extremely useful tool for probing PKC-dependent physiology2 or signaling pathways3. Increases MSC adhesion to an ICAM-1 coated substrate in vitro and enables targeted delivery of systematically administered MSCs to inflamed sites in vivo in a CD11a-dependent manner.4? Cell permeable.

Uses

Bisindolylmaleimide X hydrochloride is a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCα by Bisindolylmaleimide X and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure.

References

1) Wilkinson et al. (1993), Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C; Biochem. J., 294 335 2) Niu et al. (2011), PKCε regulates contraction-stimulated GLUT4 traffic in skeletal muscle cells; J. Cell Physiol., 226 173 3) Jimenez-Lopez et al. (2005), Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells; J. Pharmacol. Exp. Ther., 312 998 4) Levy et al. (2015), A small-molecule screen for enhanced homing of systemically infused cells; Cell Rep., 10 1261

1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy Suppliers

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145317-11-9, 1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, MonohyRelated Search:

CALPHOSTIN C H-ARG-PHE-ALA-ARG-LYS-GLY-ALA-LEU-ARG-GLN-LYS-ASN-VAL-HIS-GLU-VAL-LYS-ASN-OH Ingenol Phloretin 1-O-HEXADECYL-2-O-ACETYL-SN-GLYCEROL CHELERYTHRINE CHLORIDE H-7 DIHYDROCHLORIDE K-252B K-252C Bisindolylmaleimide VIII acetate salt Hypericin BISINDOLYLMALEIMIDE II GF109203X GO 6976 D-ERYTHRO-SPHINGOSINE GANGLIOSIDE GD1A DISODIUM SALT 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether BISINDOLYLMALEIMIDE VII

1H-Pyrrole-2,5-dione, 3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, Monohy

1H-Pyrrole-2,5-dione,3-[8-(aMinoMethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-Methyl-1H-indol-3-yl)-, (Hydrochloride) (1:1)

Bisindoylmaleimide X HCl

BISINDOLYLMALEIMIDE X HYDROCHLORIDE (BIM-X HYDROCHLORIDE)

Bisindoylmaleimide X hydrochloride ≥95%

3-[8-(aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione

Bisindoylmaleimide X (Ro 31-8425)

BIM X

BIM X;RO 31-8425RO 31-8425

Ro 31-8425 Ro 31-8425

BIM-X hydrochloride

3-(8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione hydrochloride

Bisindolylmaleimide X hydrochloride (Ro 31-8425), PKC inhibitor

145317-11-9