ChemicalBook > CAS DataBase List > MethanesulfonaMide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]-2-pyridinyl]-N-Methyl-, hydrochloride (1:1)

MethanesulfonaMide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]-2-pyridinyl]-N-Methyl-, hydrochloride (1:1)

Product Name
MethanesulfonaMide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]-2-pyridinyl]-N-Methyl-, hydrochloride (1:1)
CAS No.
939791-41-0
Chemical Name
MethanesulfonaMide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]-2-pyridinyl]-N-Methyl-, hydrochloride (1:1)
Synonyms
PF-562271 HCl ，S7357;PF-562271 hydrochloride;PF562271 HCL;PF 562271 HCL;PF562271 hydrochloride. PF271, PF-271, PF 271;N-methyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethylpyrimidin-4-ylamino]methyl}pyridin-2-yl)methanesulfonamide hydrochloride;PF562271; PF562271; PF-562271; PF562,271; PF562,271; PF-562,271; PF-00562271; PF00562271; PF 00562271; PF562271 HYDROCHLORIDE. PF271, PF-271, PF 271;N-methyl-N-[3-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide:hydrochloride;MethanesulfonaMide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]-2-pyridinyl]-N-Methyl-, hydrochloride (1:1);Proline-rich tyrosine kinase 2,Ewing,inhibit,Antitumor,PF-562271,Focal adhesion kinase,Sarcoma,FAK,VS-6062(hydrochloride),PTK2 protein tyrosine kinase 2,Pyk2,PF562271 hydrochloride,PTK2,PF 562271,PF562271,Cancer,PF 562271 hydrochloride,Inhibitor,Breast
CBNumber
CB82667582
Molecular Formula
C21H21ClF3N7O3S
Formula Weight
543.95
MOL File
939791-41-0.mol
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MethanesulfonaMide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]-2-pyridinyl]-N-Methyl-, hydrochloride (1:1) Property

storage temp. 
Store at -20°C
solubility 
≥26.35 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
form 
solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology
Product number
A8345
Product name
PF-562271HCl
Packaging
5mg
Price
$120
Updated
2021/12/16
ApexBio Technology
Product number
A8345
Product name
PF-562271HCl
Packaging
10mg
Price
$190
Updated
2021/12/16
More
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MethanesulfonaMide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]-2-pyridinyl]-N-Methyl-, hydrochloride (1:1) Chemical Properties,Usage,Production

Uses

PF-562271 (VS-6062) hydrochloride is a potent, ATP-competitive and reversible FAK and Pyk2 kinase inhibitor with IC50s of 1.5 nM and 13 nM, respectively[1].

Biological Activity

pf-562271 is a potent, atp-competitive and reversible inhibitor of both focal adhesion kinase (fak), a non-receptor tyrosine kinase involved in a variety of cellular events, and proline-rich tyrosine kinase 2 (pyk2), an fak homolog containing 48% amino acid identity, with half maximal inhibitory concentration (ic50) of 1.5 nmol/l and 14 nmol/l respectively. as a potential therapeutic agent either alone or in combination with other agents for the treatment of cancer, pf-562271 has been reported to effectively inhibit the proliferation of tumors in both xenograft and transgenic mouse models, in which it dose-dependently inhibits fak phosphorylation in tumor-bearing mice with half maximal effective concentration (ec50) of 93 ng/ml.

in vivo

PF-562271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion (calculated EC50 of 93 ng/mL, total) after p.o. administration to tumor-bearing mice[1]. Rats that receive PF-562271 demonstrate a decrease in tumor growth after 2 weeks of treatment with signs of bone healing as evidenced by the deposition of new bone (cortical and cancellous) at sites previously damaged by the tumor[3].

References

[1]stokes jb, adair sj, slack-davis jk, walters dm, tilghman rw, hershey ed, lowrey b, thomas ks, bouton ah, hwang rf, stelow eb, parsons jt, bauer tw. inhibition of focal adhesion kinase by pf-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment. mol cancer ther. 2011 nov;10(11):2135-45. doi: 10.1158/1535-7163.mct-11-0261. epub 2011 sep 8.
[2]roberts wg, ung e, whalen p, cooper b, hulford c, autry c, richter d, emerson e, lin j, kath j, coleman k, yao l, martinez-alsina l, lorenzen m, berliner m, luzzio m, patel n, schmitt e, lagreca s, jani j, wessel m, marr e, griffor m, vajdos f. antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, pf-562,271. cancer res. 2008 mar 15;68(6):1935-44. doi: 10.1158/0008-5472.can-07-5155.

MethanesulfonaMide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]-2-pyridinyl]-N-Methyl-, hydrochloride (1:1) Preparation Products And Raw materials

Raw materials

Preparation Products

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MethanesulfonaMide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]-2-pyridinyl]-N-Methyl-, hydrochloride (1:1) Suppliers

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939791-41-0, MethanesulfonaMide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]-2-pyridinyl]-N-Methyl-, hydrochloride (1:1)Related Search:

PIPES N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide PF 573228 PF-06882961 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid PF-04979064 PF-3758309 PF-05212384 PF-06281355 PF-06281355 PF-562271 Ketohexokinase inhibitor 1 PF-6274484 PF-9366 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione PF06869206 PF06869206

  • MethanesulfonaMide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)aMino]-5-(trifluoroMethyl)-4-pyriMidinyl]aMino]Methyl]-2-pyridinyl]-N-Methyl-, hydrochloride (1:1)
  • N-methyl-N-[3-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide:hydrochloride
  • PF562271 hydrochloride. PF271, PF-271, PF 271
  • PF562271; PF562271; PF-562271; PF562,271; PF562,271; PF-562,271; PF-00562271; PF00562271; PF 00562271; PF562271 HYDROCHLORIDE. PF271, PF-271, PF 271
  • PF562271 HCL;PF 562271 HCL
  • N-methyl-N-(3-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethylpyrimidin-4-ylamino]methyl}pyridin-2-yl)methanesulfonamide hydrochloride
  • PF-562271 hydrochloride
  • Proline-rich tyrosine kinase 2,Ewing,inhibit,Antitumor,PF-562271,Focal adhesion kinase,Sarcoma,FAK,VS-6062(hydrochloride),PTK2 protein tyrosine kinase 2,Pyk2,PF562271 hydrochloride,PTK2,PF 562271,PF562271,Cancer,PF 562271 hydrochloride,Inhibitor,Breast
  • PF-562271 HCl ，S7357
  • 939791-41-0
  • C21H20F3N7O3SClH