Uses Preparation References
ChemicalBook > CAS DataBase List > 2,2-Difluoro-1,3-benzodioxole

2,2-Difluoro-1,3-benzodioxole

Uses Preparation References
Product Name
2,2-Difluoro-1,3-benzodioxole
CAS No.
1583-59-1
Chemical Name
2,2-Difluoro-1,3-benzodioxole
Synonyms
2,2-Difluoro-1,3-ben;uoro-1,3-benzodioxoL;LABOTEST-BB LT01148491;2,2-DIFLUOROBENZODIOXOLE;2,2-Difluoro-1,3-benzodixole;2,2-DIFLUORO-1,3-BENZODIOXOLE;difluoromethylenedioxybenzene;2,2-DIFLUORO-BENZO[1,3]DIOXOLE;2,2-difluoro-1,3-benozodioxole;1,3-Benzodioxole, 2,2-difluoro-
CBNumber
CB8295369
Molecular Formula
C7H4F2O2
Formula Weight
158.1
MOL File
1583-59-1.mol
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2,2-Difluoro-1,3-benzodioxole Property

Boiling point:
129-130°C
Density 
1,308 g/cm3
refractive index 
1.443
Flash point:
129-130°C
storage temp. 
2-8°C
solubility 
Chloroform, Methanol
form 
Oil
color 
Clear Colourless
BRN 
1307648
InChIKey
DGCOGZQDAXUUBY-UHFFFAOYSA-N
LogP
2.96
CAS DataBase Reference
1583-59-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-43
Safety Statements 
26-36/37/39-36/37
RIDADR 
UN1993
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
3
PackingGroup 
III
HS Code 
2932990090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
740756
Product name
2,2-Difluoro-1,3-benzodioxole
Purity
97%
Packaging
5g
Price
$23.5
Updated
2024/03/01
TCI Chemical
Product number
D4051
Product name
2,2-Difluoro-1,3-benzodioxole
Purity
>98.0%(GC)
Packaging
5g
Price
$42
Updated
2024/03/01
TCI Chemical
Product number
D4051
Product name
2,2-Difluoro-1,3-benzodioxole
Purity
>98.0%(GC)
Packaging
25g
Price
$126
Updated
2024/03/01
Alfa Aesar
Product number
B20540
Product name
2,2-Difluoro-1,3-benzodioxole, 97%
Packaging
5g
Price
$65.65
Updated
2024/03/01
Alfa Aesar
Product number
B20540
Product name
2,2-Difluoro-1,3-benzodioxole, 97%
Packaging
25g
Price
$200.65
Updated
2024/03/01
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2,2-Difluoro-1,3-benzodioxole Chemical Properties,Usage,Production

Uses

2,2-Difluoro-1,3-benzodioxole is an intermediate compound which is used especially for the preparation of products for agricultural chemistry and for the synthesis of pharmaceutical products.
2,2-difluoro-1,3-benzodioxole is a useful difluoromethylated building block for the synthesis of various benzodioxole-containing pharmaceutical active compounds.
2-,3-,and 4-(Trifluoromethoxy)phenyllithiums: Versatile intermediates offering access to a variety of new organofluorine compounds.
Selective aliphatic fluorination by halogen exchange in mild conditions.

Preparation

2,2-Difluoro-1,3-benzodioxole is prepared by reaction of 2,2-dichloro-1,3-benzodioxole with potassium fluoride in the presence of an effective quantity of a catalyst selected from potassium hydrogen fluoride, sodium hydrogen fluoride, cesium hydrogen fluoride, rubidium hydrogen fluoride, and quaternary ammonium hydrogen fluoride.
https://patents.google.com/patent/US5432290A/en

References

[1] E.Castagnetti, et al, Eur. J. Org. Chem., 2001, 2001(4), pp 691-695.
[2] L.Saint-Jalmes, J. F. Chem., 2006, 127(1), pp 85-90.

Chemical Properties

Colorless to pale yellow liquid

Uses

2,2-Difluoro-1,3-benzodioxole is used in the synthesis of Kv3 inhibitors as well as in the preparation of renin inhibitors.

2,2-Difluoro-1,3-benzodioxole Preparation Products And Raw materials

Raw materials

Preparation Products

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2,2-Difluoro-1,3-benzodioxole Suppliers

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View Lastest Price from 2,2-Difluoro-1,3-benzodioxole manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
Ethynyltrimethylsilane 1583-59-1
Price
US $10.00/kg
Min. Order
1kg
Purity
99.6%
Supply Ability
100000
Release date
2024-04-24
Henan Fengda Chemical Co., Ltd
Product
2,2-Difluoro-1,3-benzodioxole 1583-59-1
Price
US $80.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-27
Hebei Guanlang Biotechnology Co,.LTD
Product
2,2-Difluoro-1,3-Benzodioxole 1583-59-1
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2023-07-24

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