2,2-Difluoro-1,3-benzodioxole
Uses Preparation References- Product Name
- 2,2-Difluoro-1,3-benzodioxole
- CAS No.
- 1583-59-1
- Chemical Name
- 2,2-Difluoro-1,3-benzodioxole
- Synonyms
- 2,2-Difluoro-1,3-ben;uoro-1,3-benzodioxoL;LABOTEST-BB LT01148491;2,2-DIFLUOROBENZODIOXOLE;2,2-Difluoro-1,3-benzodixole;2,2-DIFLUORO-1,3-BENZODIOXOLE;difluoromethylenedioxybenzene;2,2-DIFLUORO-BENZO[1,3]DIOXOLE;2,2-difluoro-1,3-benozodioxole;1,3-Benzodioxole, 2,2-difluoro-
- CBNumber
- CB8295369
- Molecular Formula
- C7H4F2O2
- Formula Weight
- 158.1
- MOL File
- 1583-59-1.mol
2,2-Difluoro-1,3-benzodioxole Property
- Boiling point:
- 129-130°C
- Density
- 1,308 g/cm3
- refractive index
- 1.443
- Flash point:
- 129-130°C
- storage temp.
- 2-8°C
- solubility
- Chloroform, Methanol
- form
- Oil
- color
- Clear Colourless
- BRN
- 1307648
- InChIKey
- DGCOGZQDAXUUBY-UHFFFAOYSA-N
- LogP
- 2.96
- CAS DataBase Reference
- 1583-59-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-43
- Safety Statements
- 26-36/37/39-36/37
- RIDADR
- UN1993
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 740756
- Product name
- 2,2-Difluoro-1,3-benzodioxole
- Purity
- 97%
- Packaging
- 5g
- Price
- $23.5
- Updated
- 2024/03/01
- Product number
- D4051
- Product name
- 2,2-Difluoro-1,3-benzodioxole
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $42
- Updated
- 2024/03/01
- Product number
- D4051
- Product name
- 2,2-Difluoro-1,3-benzodioxole
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $126
- Updated
- 2024/03/01
- Product number
- B20540
- Product name
- 2,2-Difluoro-1,3-benzodioxole, 97%
- Packaging
- 5g
- Price
- $65.65
- Updated
- 2024/03/01
- Product number
- B20540
- Product name
- 2,2-Difluoro-1,3-benzodioxole, 97%
- Packaging
- 25g
- Price
- $200.65
- Updated
- 2024/03/01
2,2-Difluoro-1,3-benzodioxole Chemical Properties,Usage,Production
Uses
2,2-Difluoro-1,3-benzodioxole is an intermediate compound which is used especially for the preparation of products for agricultural chemistry and for the synthesis of pharmaceutical products.
2,2-difluoro-1,3-benzodioxole is a useful difluoromethylated building block for the synthesis of various benzodioxole-containing pharmaceutical active compounds.
2-,3-,and 4-(Trifluoromethoxy)phenyllithiums: Versatile intermediates offering access to a variety of new organofluorine compounds.
Selective aliphatic fluorination by halogen exchange in mild conditions.
Preparation
2,2-Difluoro-1,3-benzodioxole is prepared by reaction of 2,2-dichloro-1,3-benzodioxole with potassium fluoride in the presence of an effective quantity of a catalyst selected from potassium hydrogen fluoride, sodium hydrogen fluoride, cesium hydrogen fluoride, rubidium hydrogen fluoride, and quaternary ammonium hydrogen fluoride.
https://patents.google.com/patent/US5432290A/en
References
[1] E.Castagnetti, et al, Eur. J. Org. Chem., 2001, 2001(4), pp 691-695.
[2] L.Saint-Jalmes, J. F. Chem., 2006, 127(1), pp 85-90.
Chemical Properties
Colorless to pale yellow liquid
Uses
2,2-Difluoro-1,3-benzodioxole is used in the synthesis of Kv3 inhibitors as well as in the preparation of renin inhibitors.
2,2-Difluoro-1,3-benzodioxole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,2-Difluoro-1,3-benzodioxole manufacturers
- Product
- 2,2-Difluoro-1,3-Benzodioxole 1583-59-1
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-11-27
- Product
- 2,2-Difluoro-1,3-Benzodioxole 1583-59-1
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-20
- Product
- 2,2-Difluoro-1,3-benzodioxole 1583-59-1
- Price
- US $80.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-27