E3 ligase Ligand-Linker Conjugates 6
- Product Name
- E3 ligase Ligand-Linker Conjugates 6
- CAS No.
- 2097973-72-1
- Chemical Name
- E3 ligase Ligand-Linker Conjugates 6
- Synonyms
- VH032-PEG2-NH2 hydrochloride;S)-AHPC-PEG2-NH2 hydrochloride;(S,R,S)-AHPC-PEG2-NH2 hydrochloride;E3 ligase Ligand-Linker Conjugates 6;(S,R,S)-AHPC-PEG2-NH2 hydrochloride >=95%;VHL Ligand-Linker Conjugates 3 hydrochloride;(S,R,S)-AHPC-PEG2-NH2 hydrochloride E3 ligase Ligand-Linker Conjugates 6);(2S,4R)-1-((S)-2-(2-(2-(2-aminoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride;inhibit,E3 Ligase Ligand-Linker Conjugates,Inhibitor,VHL Ligand-Linker Conjugates 3,(S,R,S) AHPC PEG2 NH2 hydrochloride,(S,R,S)AHPCPEG2NH2 hydrochloride,(S,R,S)-AHPC-PEG-2-NH2 hydrochloride;(2S,4R)-1-((S)-2-(2-(2-(2-Aminoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
- CBNumber
- CB83386473
- Molecular Formula
- C28H42ClN5O6S
- Formula Weight
- 612.18
- MOL File
- 2097973-72-1.mol
E3 ligase Ligand-Linker Conjugates 6 Property
- storage temp.
- 2-8°C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 901488
- Product name
- (S,R,S)-AHPC-PEG2-NH2 hydrochloride
- Purity
- ≥95%
- Packaging
- 50MG
- Price
- $688
- Updated
- 2023/06/20
- Product number
- PTC1320
- Product name
- (S,R,S)-AHPC-PEG2-NH2 hydrochloride
- Packaging
- 50mg
- Price
- $499.5
- Updated
- 2021/12/16
E3 ligase Ligand-Linker Conjugates 6 Chemical Properties,Usage,Production
Uses
Protein degrader builiding block (S,R,S)-AHPC-PEG2-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
E3 ligase Ligand-Linker Conjugates 6 Preparation Products And Raw materials
Raw materials
Preparation Products
E3 ligase Ligand-Linker Conjugates 6 Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
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- 19892
- Advantage
- 58
- Tel
- +1-833-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 52927
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View Lastest Price from E3 ligase Ligand-Linker Conjugates 6 manufacturers
- Product
- (S,R,S)-AHPC-PEG2-NH2 hydrochloride 2097973-72-1
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- >98.00%
- Supply Ability
- 100mg
- Release date
- 2024-04-01