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Phosphorus tribromide

Product Name
Phosphorus tribromide
CAS No.
7789-60-8
Chemical Name
Phosphorus tribromide
Synonyms
PBr3;Phosphorous tribromide;tribroMophosphane;tribromophosphine;PHOSPHORUS BROMIDE;Phosphorus(Ⅲ)bromide;extrema[qr];Phosphortribromid;phosphrous broMide;phosphorousbromide
CBNumber
CB8372891
Molecular Formula
Br3P
Formula Weight
270.69
MOL File
7789-60-8.mol
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Phosphorus tribromide Property

Melting point:
-41.5 °C (lit.)
Boiling point:
175 °C (lit.)
Density 
2.88 g/mL at 20 °C (lit.)
vapor density 
9.3 (vs air)
vapor pressure 
0.27 psi ( 54 °C)
refractive index 
n20/D 1.697(lit.)
Flash point:
172.9°C
storage temp. 
Store below +30°C.
solubility 
soluble in Ether,Acetone,Chloroform
form 
Liquid
Specific Gravity
2.88
color 
Clear to slightly hazy colorless to yellow or light brown
Odor
Irritating odour
Water Solubility 
reacts
FreezingPoint 
-40℃
Sensitive 
Moisture Sensitive
Merck 
14,7357
BRN 
3903060
Dielectric constant
3.9（20℃）
Stability:
Stable, but reacts violently with water. Incompatible with moisture, strong bases, strong oxidizing agents, reactive metals, acids, alcohols.
InChIKey
IPNPIHIZVLFAFP-UHFFFAOYSA-N
LogP
2.394 (est)
CAS DataBase Reference
7789-60-8(CAS DataBase Reference)
NIST Chemistry Reference
Phosphorus tribromide(7789-60-8)
EPA Substance Registry System
Phosphorus tribromide (7789-60-8)
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Safety

Hazard Codes 
C
Risk Statements 
34-37-40-14-67
Safety Statements 
26-45-36/37-36/37/39
RIDADR 
UN 3264 8/PG 2
WGK Germany 
2
RTECS 
TH4460000
F 
21
TSCA 
Yes
HS Code 
2812 90 00
HazardClass 
8
PackingGroup 
II
Hazardous Substances Data
7789-60-8(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.22321
Product name
Phosphorus tribromide
Purity
for synthesis
Packaging
50mL
Price
$78.5
Updated
2024/03/01
Sigma-Aldrich
Product number
8.22321
Product name
Phosphorus tribromide
Purity
for synthesis
Packaging
250ML
Price
$360
Updated
2024/03/01
Sigma-Aldrich
Product number
157783
Product name
Phosphorus tribromide
Purity
97%
Packaging
100g
Price
$105
Updated
2024/03/01
Sigma-Aldrich
Product number
157783
Product name
Phosphorus tribromide
Purity
97%
Packaging
500g
Price
$182
Updated
2024/03/01
TCI Chemical
Product number
P1743
Product name
Phosphorus Tribromide
Purity
>98.0%(T)
Packaging
300g
Price
$53
Updated
2024/03/01
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Phosphorus tribromide Chemical Properties,Usage,Production

Chemical Properties

Phosphorus tribromide is a colourless liquid(possibly hazy) with the formula PBr3. It fumes in air due to hydrolysis and has a penetrating odour. It is widely used in the laboratory for the conversion of alcohols toalkyl bromides.
Phosphorus tribromide (PBr3) is commonly used in Hell-Volhard-Zelinsky halogenation for the α-bromination of carboxylic acids to form the corresponding acyl bromide. It is also useful for the conversion of primary and secondary alcohols to alkyl bromides.

Uses

Phosphorus tribromide is used mainly for the conversion of alcohols to alkyl bromides and it is used in tests for skin corrosivity. It is used for alkene preparation and it act as a lewis base and a lewis acid. Phosphorus tribromide is used in the manufacture of pharmaceuticals such as alprazolam, methohexital and fenoprofen.
Phosphorus tribromide may be used as a reagent:
In a novel protocol for synthesizing 7-ethoxy-1-(p-ethylphenoxy)-3,7-dimethyl-2-octene, a synthetic juvenile hormone mimic of trans,trans,cis-10,11-epoxy-7-ethyl-3,11-dimethyltrideca-2,6-dienoate.
To synthesize 1,2,3-diazaphosphinane, 1,2,3-thiazaphosphinine and 1,2-azaphosphole bearing a chromone ring.
To synthesize 1-Bromoundec-1-ene from 10-undecen-1-ol.

Uses

Phosphorus(III) bromide is used mainly for the conversion of alcohols to alkyl bromides and it is used in tests for skin corrosivity. It is used for alkene preparation and it act as a lewis base and a lewis acid. It is used as a catalyst for the alpha-bromination of carboxylic acids and used as intermediates in hell-volhard-zelinsky halogenation. Phosphorus tribromide is used in the manufacture of pharmaceuticals such as alprazolam, methohexital and fenoprofen. It is also used as a fire suppression agent.

Preparation

Phosphorus tribromide, PBr3, is most conveniently prepared by reaction between liquid bromine and a solution of white phosphorus in PBr3. In most of its reactions, the tribromide resembles the trichloride although the former has been much less studied and in some cases the products seem to be more complex.

Reactions

Silyl phosphites such as (EtO)2POSiMe3 and (Et3SiO)3P are known. The latter compound can be prepared in 30% yield by reacting phosphorus tribromide with an organosilane in the presence of zinc chloride. Esters of the former type can be made by reaction.
3Et3SiO+PBr3–-(Et3SiO)3+3RBr
Et3SiONa+(EtO)2PCl–-(EtO)2POSiEt3+NaCl)

General Description

A colorless fuming liquid with a pungent odor. Corrosive to metals and tissue. Boiling point 347°F (175°C). Freezing point -40°F (-40°C).

Air & Water Reactions

Fumes in air. Decomposed by water to form phosphoric acid and hydrobromic acid. Reaction with warm water is very rapid and may be violent [Mellor v.8. 1032 1940].

Reactivity Profile

Phosphorus tribromide reacts with oxidizing agents to generate heat and products that may be flammable, combustible, or otherwise reactive; the reactions may be violent. Forms complexes with potassium or sodium metal that explode when shocked. Drop wise addition to 3-phenylpropanol caused an explosion when stirring of the mixture was discontinued [Chem. Brit., 1974, 10, 101-102].

Health Hazard

Inhalation causes severe irritation of nose, throat, and lungs. Ingestion causes burns of mouth and stomach. Contact with eyes or skin causes severe burns.

Safety Profile

Probably highly toxic. A corrosive irritant to the eyes, skin, and mucous membranes. Wdl react with water, steam, or acids to produce heat, toxic and corrosive fumes. Violent reaction or ignition with calcium hydroxide + sodium carbonate, phenylpropanol, sulfuric acid, oleum, fluorosulfuric acid, chlorosulfuric acid, 1,1,1 -tris(hydroxymethyl)methane, water, potassium, sodium, RuO4. When heated to decomposition it emits very toxic fumes of Brand POx. See also PHOSPHIDES and BROMIDES.

Purification Methods

It is decomposed by moisture, it should be kept dry and is corrosive. Purify it by distillation through an efficient fractionating column [see Whitmore & Lux J Am Chem Soc 54 3451] in a slow stream of dry N2, i.e. under strictly dry conditions. [Gay & Maxson Inorg Synth II 147 1946, Org Synth Col Vol II 358 1943.] Dissolve it in CCl4, dry it over CaCl2, filter and distil it. Store it in sealed ampoules under N2 and keep it away from light. HARMFUL VAPOURS.

Phosphorus tribromide Preparation Products And Raw materials

Raw materials

Government regulation Phosphorus

Preparation Products

3-(3-Hydroxyphenyl)-DL-alanine 6-Fluoro-4-(trifluoromethyl)quinolin-2-amine ,97% 4-BROMO-TETRAHYDROPYRAN 4-TERT-BUTYLCYCLOHEXANECARBOXYLIC ACID 2-(2-FLUORO-PHENYL)-ETHANESULFONYL CHLORIDE 3-BROMO-CYCLOPENT-2-ENOL Tetrahydropyranyl-4-acetic acid 3,3,3-Trifluoropropionic acid 4-BROMO-6-(TRIFLUOROMETHYL)PYRIMIDINE TETRAHYDRO-2H-PYRAN-4-YLACETYL CHLORIDE 1-(2-ETHOXYETHYL)PIPERAZINE Cyclohexylamine hydrobromide 3,5-DIMETHOXYPHENYLACETONITRILE 2-Fluoroethyl bromide GUANETHIDINE SULFATE 3,5-DIMETHOXYBENZYL BROMIDE 2-(4-FLUORO-PHENYL)-ETHANESULFONYL CHLORIDE N-(2-BROMO-3-PYRIDINYL)ACETAMIDE (4-FLUORO-BENZYL)-METHYL-AMINE 4-(Trifluoromethyl)quinoline-2-carbohydrazide ,97% (6-Fluoro-4-(trifluoromethyl)quinolin-2-yl)methanol ,97% Ethyl 6-fluoro-4-(trifluoromethyl)quinoline-2-carboxylate ,97% 1-(2-Methoxyethyl)hydrazine 2-Bromo-6-fluoro-4-(trifluoromethyl)quinoline 2-HYDROXY-5-NITROBENZYL BROMIDE 2-(4-CHLORO-PHENYL)-ETHANESULFONYL CHLORIDE 5-ACETAMIDO-2-BROMOPYRIDINE 2-METHOXY-5-(2'-ETHYLHEXYLOXY)BENZENE-1& 2-(1,5-Dimethyl-1H-pyrazol-3-yl)acetonitrile ,97% (4-(Trifluoromethyl)quinolin-2-yl)methanol ,97% 2-Bromo-3-nitropyridine 2-(2-CHLORO-PHENYL)-ETHANESULFONYL CHLORIDE 2-BROMO-4-(TRIFLUOROMETHYL)PYRIMIDINE 4-(Trifluoromethyl)quinolin-2-amine 5-Bromomethyl-1,3-dimethyl-1H-pyrazole ,97% 2-BROMO-4-(TRIFLUOROMETHYL)QUINOLINE Cyclohexylmethyl bromide (2-FLUOROBENZYL)METHYLAMINE 4-TRIFLUOROMETHYL-QUINOLINE-2-CARBOXYLIC ACID 2-Bromoethyl ethyl ether
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View Lastest Price from Phosphorus tribromide manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
Phosphorus tribromide 7789-60-8
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-21
Hebei Miaoyin Technology Co.,Ltd
Product
Phosphorus tribromide 7789-60-8
Price
US $20.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10000
Release date
2023-04-18
Hebei Weibang Biotechnology Co., Ltd
Product
Phosphorus tribromide 7789-60-8
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-12-04

7789-60-8, Phosphorus tribromideRelated Search:

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