BMS-852927

Product Name: BMS-852927
CAS No.: 1256918-39-4
Chemical Name: BMS-852927
Synonyms: XL041;XL-041);BMS-852927;XL041,XL-041;XL041（BMS-852927）;BMS-852927 (BMS 852927;2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3,3'-difluoro-4'-(hydroxymethyl)-5'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-4-yl)propan-2-ol;1H-Imidazole-4-methanol, 2-[1-(2,6-dichlorophenyl)-1-methylethyl]-1-[3,3'-difluoro-4'-(hydroxymethyl)-5'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]-α,α-dimethyl-
CBNumber: CB84187952
Molecular Formula: C29H28Cl2F2N2O4S
Formula Weight: 609.51
MOL File: 1256918-39-4.mol

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BMS-852927 Property

Boiling point:: 810.6±75.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 150 mg/mL (246.10 mM)
form: Solid
pka: 11.20±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-7926
Product name: XL041
Purity: 99.44%
Packaging: 1mg
Price: $132
Updated: 2021/12/16

ChemScene

Product number: CS-7926
Product name: XL041
Purity: 99.44%
Packaging: 5mg
Price: $396
Updated: 2021/12/16

ChemScene

Product number: CS-7926
Product name: XL041
Purity: 99.44%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-7926
Product name: XL041
Purity: 99.44%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

ChemScene

Product number: CS-7926
Product name: XL041
Purity: 99.44%
Packaging: 100mg
Price: $2520
Updated: 2021/12/16

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BMS-852927 Chemical Properties,Usage,Production

Uses

XL041 (BMS-852927) is an LXRβ-selective agonist.

in vivo

XL041 (BMS-852927), has a very favorable profile at efficacious doses in cynomolgus monkeys and mice. XL041 pre-treatment of C57BL/6J mice for 7 days results in potent, dose-dependent stimulation of cholesterol efflux in this system, reaching a maximum in the 3 mg/kg/day dose group of 70% above vehicle in the initial efflux rate. Similar results are obtained in LDLR knockout (KO) mice. In a separate study, XL041 inhibits the progression of atherosclerosis in a 12 week study in LDLR KO mice. Importantly, the dose response for inhibition of atherosclerosis (0.1-3 mg/kg/day) is similar to the dose response for macrophage reverse cholesterol transport (RCT) stimulation (0.03-3 mg/kg/day), a major underlying mechanism through which LXR agonists affect the disease^[1].

References

[1] Kirchgessner TG, et al. Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils. Cell Metab. 2016 Aug 9;24(2):223-33. DOI:10.1016/j.cmet.2016.07.016

BMS-852927 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS-852927 Suppliers

China 22 United States 2 Global 24

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1256918-39-4, BMS-852927Related Search:

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BMS-852927

2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3,3'-difluoro-4'-(hydroxymethyl)-5'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-4-yl)propan-2-ol

BMS-852927 (BMS 852927

XL041

XL-041)

1H-Imidazole-4-methanol, 2-[1-(2,6-dichlorophenyl)-1-methylethyl]-1-[3,3'-difluoro-4'-(hydroxymethyl)-5'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]-α,α-dimethyl-

XL041（BMS-852927）

XL041,XL-041

1256918-39-4

256918-39-4

C29H28Cl2F2N2O4S